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Thalassemia

Hematology/Oncology Clinics of North America, 2023
Edward J, Benz, Vijay G, Sankaran
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Update on Thalassemia

Pediatrics In Review, 1992
Many advances in the understanding and management of the thalassmia syndromes have been made during the past several years. Our knowledge of normal globin gene function and of the consequences of specific mutations has been advanced by identification of the genetic defects causing thalassemia.
P J, Giardina, M W, Hilgartner
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PATHOPHYSIOLOGY OF THALASSEMIA

Annals of the New York Academy of Sciences, 1980
The clinical manifestations in homozygous thalassemia may be attributed to the defect in hemoglobin synthesis (Figure 16). It is best typified by beta thalassemia, where excess alpha chains accumulate to form intracytoplasmic erythrocytic inclusions. This leads to anemia, bone marrow hyperplasia, osteoporosis, hemosiderosis, and organ failure.
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Thalassemia in Pakistan

Hemoglobin, 2022
The estimated population of Pakistan is approximately 225,633,392 (225 million). The healthcare delivery system of Pakistan is complex because it includes healthcare subsystems operated by both the federal government and the provincial government. In Pakistan β-thalassemia (β-thal) trait frequency ranges between 5.0-7.0%, thus, there are more than 10 ...
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Thalassemia in Pregnancy

Clinical Obstetrics and Gynecology, 1995
The responsibility of the obstetrician is to identify during the first trimester women who are carriers for thalassemia. When she has been identified, the father of the baby should be screened and if he is also a carrier, the couple should be offered prenatal diagnosis.
S J, Kilpatrick, R K, Laros
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Thalassemia in Sikhs

Blood, 1956
Abstract 1. The incidence of Thalassemia minor in the Sikh community of Vancouver, Canada, was computed to be six per cent from a study of 80 individuals, of whom five showed this condition. 2. To determine the incidence in blood relatives, the families of the above five propositi were then studied in detail.
J K, SIDDOO   +4 more
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Pathophysiology of thalassemia

Current Opinion in Hematology, 2002
Despite discoveries concerning the molecular abnormalities that led to the thalassemic syndromes, it still is not known how accumulation of excess unmatched alpha-globin in beta thalassemia and beta-globin in alpha thalassemia leads to red blood cell hemolysis in the peripheral blood, and in the beta thalassemias particularly, premature destruction of ...
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Thalassemia

Annual Review of Medicine, 1975
B G, Forget, D G, Nathan
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Teatime for Thalassemia

JAMA: The Journal of the American Medical Association, 1979
As every schoolchild knows, tea played an important role in the political strategy of the American Revolution. The tea boycott and the Boston Tea Party are matters of recorded history. Less well known is the medical accompaniment to the political performance.
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