Results 61 to 70 of about 3,873 (265)
Inherited hemoglobin disorders in an Afro-Amazonian community: Saracura
Genetics and Molecular Biology, 2012 The most common hemoglobinopathies, viz, hemoglobins S and C, and α-and β-thalassemias, were investigated through the molecular screening of 116 subjects from the community of Saracura, comprising fugitive African slaves from farms of the ...
Greice Lemos Cardoso +2 more
doaj
Revista Brasileira de Hematologia e Hemoterapia, 2003 Thalassemias are a heterogeneous group of inherited disorders characterized by a microcytic hypochromic anemia and an imbalance in the synthesis of the globin-chains. Hb C is the second most frequently variant of hemoglobin found in Brazil.
Claudia R. Bonini-Domingos +4 more
doaj +1 more source
Canadian Medical Association Journal, 2020 Hayley, Merkeley, Lauren, Bolster
openaire +2 more sources
International Journal of Osteoarchaeology, EarlyView.ABSTRACT This osteobiography explores the life history of an adolescent who lived during the early‐mid Bronze Age (c. 1000–700 bce) and was buried at Nyaung'gan, a site in north‐central Myanmar. Burial 3b had multiple skeletal lesions, and their bones were covered in well‐remodeled subperiosteal new bone.
Anna Willis +3 more
wiley +1 more source
IRON METABOLISM IN THALASSEMIA AND SICKLE CELL DISEASE
Mediterranean Journal of Hematology and Infectious Diseases, 2009 There are two main mechanisms by which iron overload develops in thalassemias: increased iron absorption due to ineffective erythropoiesis and blood transfusions.
Raffaella Mariani +3 more
doaj +1 more source
Hemoglobin A2 Cut off Values in Egyptian Cohort as a marker of β -Thalassemia carriers. [PDF]
Journal of Bioscience and Applied Research, 2015 Beta thalassemias (β-thalassemias) are a group of inherited blood disorders caused by reduced or absent synthesis of beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals.
Noura Kablan +5 more
doaj +1 more source
Management of the Thalassemias [PDF]
Cold Spring Harbor Perspectives in Medicine, 2013 During the last 30 years, in addition to the considerable progress made in control and prevention of thalassemias(3), there have also been major advances in their symptomatic management, at least in wealthier countries where appropriate facilities are available.
Nancy F, Olivieri, Gary M, Brittenham
openaire +2 more sources
Prenatal Diagnosis, EarlyView.ABSTRACT Aim In this article, we present two cases of severe fetal hemolytic anemia based on a beta‐thalassaemia trait inherited from a single parent. Results These cases, presented at 20 and 28 weeks' gestation, necessitated intra‐uterine blood transfusions.
Eva van der Meij +11 more
wiley +1 more source
Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis
Prenatal Diagnosis, EarlyView.ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell +6 more
wiley +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde +4 more
wiley +1 more source