Results 61 to 70 of about 4,160 (239)
, 2012 Background and Aims : Saudi Arabia falls in the high prevalent zone of α and β thalassemias. Early screening for the type of thalassemia is essential for further investigations and management.
Mehdi, Syed Riaz +1 more
core +1 more source
Neuroprotection, EarlyView.Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji +4 more
wiley +1 more source
Revista Brasileira de Hematologia e Hemoterapia, 2003 Thalassemias are a heterogeneous group of inherited disorders characterized by a microcytic hypochromic anemia and an imbalance in the synthesis of the globin-chains. Hb C is the second most frequently variant of hemoglobin found in Brazil.
Claudia R. Bonini-Domingos +4 more
doaj +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Aim In this article, we present two cases of severe fetal hemolytic anemia based on a beta‐thalassaemia trait inherited from a single parent. Results These cases, presented at 20 and 28 weeks' gestation, necessitated intra‐uterine blood transfusions.
Eva van der Meij +11 more
wiley +1 more source
PRENATAL DIAGNOSIS OF β-THALASSEMIAS AND HEMOGLOBINOPATHIES
Mediterranean Journal of Hematology and Infectious Diseases, 2009 Prenatal diagnosis of β-thalassemia was accomplished for the first time in the 1970s by globin chain synthesis analysis on fetal blood obtained by placental aspiration at 18-22 weeks gestation.
Maria Cristina Rosatelli, Luisella Saba
doaj +3 more sources
Applied Sciences, 2019 Screening programs for genetic and metabolic diseases such as haemoglobinopathies, thalassemias and diabetes are a worldwide problem that faces economic and technological limitations.
Ricardo J. Pais +5 more
doaj +1 more source
Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis
Prenatal Diagnosis, EarlyView.ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell +6 more
wiley +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde +4 more
wiley +1 more source
Case Report: Management of Thalassemic Mother for LSCS [PDF]
The Indian Anaesthetists' Forum, 2009 Thalassemias are genetically determined heterogeneous group of disorders with reduced production of globin. We report anaesthetic management of a case of ß-Thalassemia syndrome for LSCS.
Vaijayanti N. Gadre
doaj
IRON METABOLISM IN THALASSEMIA AND SICKLE CELL DISEASE
Mediterranean Journal of Hematology and Infectious Diseases, 2009 There are two main mechanisms by which iron overload develops in thalassemias: increased iron absorption due to ineffective erythropoiesis and blood transfusions.
Raffaella Mariani +3 more
doaj +1 more source