Results 71 to 80 of about 67,878 (296)
Novel thalidomide analogues, “me too†drugs and the Brazilian law
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2013 In Brazil, thalidomide has been used virtually without interruption since it was launched as a new and revolutionary sedative drug in 1956. After 1965, when its efficacy to treat erythema nodosum leprosum (ENL) was discovered, it was regarded as an ...
Francisco José Roma Paumgartten
doaj +2 more sources
Ibrain, EarlyView.Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley +1 more source
Novel thalidomide analogues, “me too” drugs and the Brazilian law / Novos análogos da talidomida, medicamentos “me too” e a lei brasileira [PDF]
, 2013 In Brazil, thalidomide has been used virtually without interruption since it was launched as a new and revolutionary sedative drug in 1956. After 1965, when its effi cacy to treat erythema nodosum leprosum (ENL) was discovered, it was regarded as an ...
Francisco José Roma Paumgartten
core +2 more sources
Structural dynamics of the cereblon ligand binding domain.
PLoS ONE, 2015 Cereblon, a primary target of thalidomide and its derivatives, has been characterized structurally from both bacteria and animals. Especially well studied is the thalidomide binding domain, CULT, which shows an invariable structure across different ...
Marcus D Hartmann +4 more
doaj +1 more source
, 1999 The second in a series re-evaluating hazards identified in the 1950s and ...
Jacobson, Kevin, Mazur, Allan
core +1 more source
VIEW, EarlyView.MTV can greatly achieved antigen presenting cell (APCs), and THA will be released from the polyplex core and enhanced antigen presenting, thereby prompting APC maturation and antigen presenting. The membrane antigens on MTV are degraded into small peptides by proteasomes and presented by MHC complexes.
Anmin Huang +9 more
wiley +1 more source
Clinical Case Reports, 2019 Thalidomide is often used for the management of refractory gastrointestinal angiodysplasia (GIAD). The tolerance, toxic profile, and compliance of thalidomide are dose‐dependent.
Harish Patel +6 more
doaj +1 more source
‘From the Fields Into the Bars’: The Story of Israel's First Transgender Novel, The Cut (1977)
Gender &History, EarlyView.ABSTRACT In 1977, an Israeli transgender woman, Judy Spotheim, published an autobiographical novel entitled The Cut. It describes the emergence of a trans community in the commercial‐sex areas of Tel Aviv‐Jaffa, hoping to humanise trans women (coccinelles). This article is the first to study the novel and present a biography of Spotheim.
Gil Engelstein, Iris Rachamimov
wiley +1 more source
Thalidomide in dermatology: Revisited
Indian Journal of Dermatology, 2015 The use of thalidomide in relation to dermatology is well- known and enough data is available in the literature about various aspects of thalidomide.
Iffat Hassan +2 more
doaj +1 more source
Scanning for therapeutic targets within the cytokine network of idiopathic inflammatory myopathies [PDF]
, 2015 The idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of chronic disorders that include dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM).
De Paepe, Boel, Zschüntzsch, Jana
core +3 more sources