Results 71 to 80 of about 47,030 (243)

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, EarlyView.
What's New? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

Neuro- and nephroprotective effect of grape seed proanthocyanidin extract against carboplatin and thalidomide through modulation of inflammation, tumor suppressor protein p53, neurotransmitters, oxidative stress and histology

Toxicology Reports, 2018
Highlights • Carboplatin and thalidomide induced neuro-nephrotoxicity.• Carboplatin and thalidomide caused inflammation.• Carboplatin and thalidomide upregulate tumor suppressor protein p53.• Carboplatin and thalidomide disturbed cytokine production ...
M. Yousef, D. Khalil, H. Abdou
semanticscholar   +1 more source

Paediatric developmental safety and the ICH E11A extrapolation of safety

British Journal of Clinical Pharmacology, EarlyView.
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Rebecca Racz, Sherbet Samuels, Dionna J. Green, Lynne P. Yao   +6 more
wiley   +1 more source

Risk factors for early postoperative complications after minimally invasive surgery in pediatric ulcerative colitis

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective To report a single‐center experience with a multidisciplinary minimally invasive surgical approach for pediatric ulcerative colitis (UC) and identify risk factors for early postoperative complications (EPC). Methods A retrospective analysis was conducted on UC patients followed at the Gastroenterology Unit of Meyer Children's ...
Martina Di Benedetto, Luca Scarallo, Sara Renzo, Sara Naldini, Monica Paci, Jacopo Barp, Federico Perna, Emilio Paolo Emma, Riccardo Coletta, Stefano Scaringi, Paolo Lionetti   +10 more
wiley   +1 more source

Thalidomide for the treatment of gastrointestinal bleeding due to angiodysplasia in a patient with Glanzmann’s thrombasthenia

Hematology Reports, 2017
Angiodysplasia is a frequent cause of persistent gastrointestinal (GI) hemorrhage in elderly patients. Although GI bleeding isn’t the most common manifestation in patients with bleeding disorders, when present, it represents a challenging complication ...
Bruno K.L. Duarte, Silvia M. de Souza, Carolina Costa-Lima, Samuel S. Medina, Margareth C. Ozelo   +4 more
doaj   +1 more source

Surgical Reconstruction in Pyoderma Gangrenosum, a Retrospective Study of Five Patients

JEADV Clinical Practice, EarlyView.
ABSTRACT Pyoderma Gangrenosum (PG) is a neutrophilic dermatosis characterized by chronic painful ulcerations most commonly on the lower extremities. Current treatment options for PG are largely nonsurgical and include the use of systemic and topical immunomodulators and wound care.
Max E. Oscherwitz, Alysia B. Kohrs, Jacob C. Maus, Matthew L. Hrin, Maria C. Mariencheck, Joseph L. Jorizzo, Kyle E. Robinson, Joseph A. Molnar, Lindsay C. Strowd   +8 more
wiley   +1 more source

The efficacy and tolerability of bortezomib, thalidomide, and dexamethasone induction therapy with a thalidomide dose step‐up strategy in patients with newly diagnosed multiple myeloma: A prospective observational study

Cancer Reports
Background Thalidomide‐containing regimens cause adverse events (AEs) that may require a reduction in treatment intensity or even treatment discontinuation in patients with multiple myeloma. As thalidomide toxicity is dose‐dependent, identifying the most
Po‐Wei Liao, Hsueh‐Ju Lu, Tsung‐Chih Chen, Hsin‐Chen Lin, Yu‐Hsuan Shih, Chieh‐Lin Jerry Teng   +5 more
doaj   +1 more source

Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation

Data in Brief, 2015
Thalidomide is a potent developmental toxicant that induces a range of birth defects, notably severe limb malformations. To unravel the molecular mechanisms underpinning the teratogenic effects of thalidomide, we used microarrays to study transcriptomic ...
Xiugong Gao, Robert L. Sprando, Jeffrey J. Yourick   +2 more
doaj   +1 more source

Thalidomide plus prednisone with or without danazol therapy in myelofibrosis: a retrospective analysis of incidence and durability of anemia response

Blood Cancer Journal, 2018
Low-dose thalidomide and prednisone alone or combined are effective therapies in some persons with primary myelofibrosis (PMF) and anemia with or with RBC transfusion dependence. Danazol is also effective in some persons with PMF and anemia. Responses to
Xueping Luo, Zefeng Xu, Bing Li, T. Qin, Peihong Zhang, Hong-li Zhang, L. Fang, L. Pan, N. Hu, S. Qu, Yue Zhang, Gang Huang, Robert Peter Gale, Zhijian Xiao   +13 more
semanticscholar   +1 more source

Assessment of Treatment Response in Patients With Scleromyxedema by the Double Modified Rodnan Skin Score

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Scleromyxedema (SMX) is a cutaneous mucinosis characterised by an abnormal accumulation of mucin in the skin and limited treatment options. Assessment of therapy response during treatment is challenging. Objectives Patients with SMX receiving high‐dose intravenous IVIg therapy were included to assess validity of the double modified ...
Julia K. Winkler, Alexander H. Enk
wiley   +1 more source