Results 81 to 90 of about 67,878 (296)
Paediatric developmental safety and the ICH E11A extrapolation of safety
British Journal of Clinical Pharmacology, EarlyView.
Gilbert J. Burckart +6 more
wiley +1 more source
Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer
Cancer Science, EarlyView.The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Toshiki Oka +26 more
wiley +1 more source
Molecular Landscape in Limb Anomalies: Diagnostic Yield and New Candidate Genes
Clinical Genetics, EarlyView.In 132 individuals with limb anomalies, diagnostic yield was 36% (47/132), including 25 novel variants, three cases with new phenotypes, and two candidate loci, HOXA11 and a small 2q31.1 deletion. Mouse data and exome‐wide analysis, key in identifying the candidate loci, represent an important opportunity for gene discovery.
Akram Mokhtari +7 more
wiley +1 more source
Thalidomide embryopathy : an enigmatic challenge [PDF]
, 2013 Thanks go to Dr. Chris Mahony, Prof. Martin Collinson, Shaunna-Leigh Beedie and Alexandra Diamond for critical comments on the paper. Thanks also go to Prof. Lynda Erskine, Dr. W. D. Figg, Dr. Lavinia Schuler-Faccini, Dr. Robert L. Smith, Prof.
Vargesson, Neil
core +1 more source
S1‐Guideline for diagnosis and therapy of necrobiosis lipoidica
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Necrobiosis lipoidica (NL) is a rare granulomatous skin disease of unknown etiology that occurs frequently in association with diabetes mellitus and other comorbidities. The predilection site is the lower leg, particularly the pretibial areas. The exact pathogenesis remains unclear.
Cornelia Erfurt‐Berge +6 more
wiley +1 more source
Hematology Reports, 2017 Angiodysplasia is a frequent cause of persistent gastrointestinal (GI) hemorrhage in elderly patients. Although GI bleeding isn’t the most common manifestation in patients with bleeding disorders, when present, it represents a challenging complication ...
Bruno K.L. Duarte +4 more
doaj +1 more source
An unusual case of intertrigo in an adult caused by purely cutaneous Langerhans cell histiocytosis [PDF]
, 2016 We report a case of persistent intertrigo in an adult, eventually diagnosed as cutaneous Langerhans cell histiocytosis (LCH). It is known that LCH has a predilection for intertriginous areas, however purely cutaneous disease as in our case, is uncommon ...
Baldacchino, Godfrey +3 more
core
International Journal of Dermatology, EarlyView.ABSTRACT Prurigo nodularis (PN) is a chronic, intensely pruritic skin disorder characterized by hyperkeratotic nodules and a debilitating itch–scratch cycle. Conventional therapies have limited efficacy and safety issues, while biologics have recently emerged as a promising alternative.
Andrea Lancz +7 more
wiley +1 more source
Data in Brief, 2015 Thalidomide is a potent developmental toxicant that induces a range of birth defects, notably severe limb malformations. To unravel the molecular mechanisms underpinning the teratogenic effects of thalidomide, we used microarrays to study transcriptomic ...
Xiugong Gao +2 more
doaj +1 more source
Using serum CA125 to assess the activity of potential cytostatic agents in ovarian cancer [PDF]
, 2014 Objective: New strategies are required to rapidly identify novel cytostatic agents before embarking on large randomized trials. This study investigates whether a change in rate of rise (slope) of serum CA125 from before to after starting a novel agent ...
Ann Petruckevitch +21 more
core +1 more source