Results 81 to 90 of about 47,030 (243)
Thalidomide-induced bronchiolitis obliterans organizing pneumonia in a patient with multiple myeloma
Saudi Journal of Kidney Diseases and Transplantation, 2019 Thalidomide, which is an angiogenesis inhibitor and immunomodulator that reduces tumor necrosis factor-alpha, has regained value in the treatment of multiple myeloma. Serious pulmonary complications due to thalidomide use remain relatively uncommon.
Zohra El Ati +11 more
doaj +1 more source
Therapeutic Options for IgA Pemphigus in Patients Refractory to Dapsone
JEADV Clinical Practice, EarlyView.ABSTRACT IgA pemphigus is a rare autoimmune blistering disorder with limited therapeutic guidance available due to its rarity and complex presentation. This comprehensive analysis evaluates the therapeutic outcomes of 67 published patients, emphasising the significant role of dapsone as the first‐line treatment.
Lorenz Frasheri +2 more
wiley +1 more source
‘From the Fields Into the Bars’: The Story of Israel's First Transgender Novel, The Cut (1977)
Gender &History, EarlyView.ABSTRACT In 1977, an Israeli transgender woman, Judy Spotheim, published an autobiographical novel entitled The Cut. It describes the emergence of a trans community in the commercial‐sex areas of Tel Aviv‐Jaffa, hoping to humanise trans women (coccinelles). This article is the first to study the novel and present a biography of Spotheim.
Gil Engelstein, Iris Rachamimov
wiley +1 more source
Thalidomide-induced Bradycardia in an Old Man
International Journal of Gerontology, 2010 We presented a case of an 82-year-old man who had classic Kaposi sarcoma. He took thalidomide 100 mg twice daily for 23 days, and then he felt light-headedness and visited our emergency department.
Ching-Hsueh Tseng +2 more
doaj +1 more source
Experimental and Therapeutic Medicine, 2017 The US Food and Drug Administration approved thalidomide and its analogues for the treatment of erythema nodosum leprosum, in spite of the notoriety of reports of severe birth defects in the middle of the last century.
Ting Liu +4 more
semanticscholar +1 more source
Evaluating “Effectiveness” under the Policy on Results
Canadian Public Administration, EarlyView.Abstract Evaluation units provide essential information for administrators of public programs. Canada's 2016 Policy on Results emphasizes evaluating “effectiveness,” with a focus on outcomes. However, it is unclear if evaluation units use this or more implementation‐oriented definitions in practice, which has implications for the information ...
Ardyn Nordstrom
wiley +1 more source
Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer
Cancer Science, EarlyView.The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Toshiki Oka +26 more
wiley +1 more source
Targeting Ikaros and Aiolos: Next‐Generation Cereblon E3 Ligase Modulators in MM
European Journal of Haematology, EarlyView.The graphical abstract illustrates the mechanism of action of cereblon E3 ligase modulators (CELMoDs) in multiple myeloma, highlighting cereblon‐mediated degradation of IKZF1 and IKZF3. Compared with classical immunomodulatory drugs (IMiDs), CELMoDs induce deeper IKZF1/3 depletion, leading to more pronounced suppression of the IRF4–MYC survival axis ...
Maria Eugenia Alvaro +12 more
wiley +1 more source
International Journal of Dental Hygiene, EarlyView.ABSTRACT Focused Question What is the association of periodontal disease (PerioD) and cardiovascular diseases (CVD/CVE) as reported in existing systematic reviews (SRs)? Methods MEDLINE‐PubMed and Cochrane‐CENTRAL databases were searched. Papers that primarily evaluate cardiovascular parameters of CVD and CVE in PerioD patients compared to non‐PerioD ...
Max G. P. Schoenmakers +4 more
wiley +1 more source