Results 151 to 160 of about 45,377 (263)

Full‐Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) Improves Symptoms of Rett Syndrome: An Open‐Label Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim The aim of this Phase I/II open‐label study was to assess the safety and efficacy of NTI164, a novel full‐spectrum medicinal cannabis plant extract 0.08% Δ‐9‐tetrahydrocannabinol (THC), in Rett syndrome (RTT). Methods Eleven female participants (5–16 years) with a pathogenic variant in the MECP2 gene were recruited to this study, receiving
B. A. Keating, Y. Ogru, T. G. Duthy, L. Douglas, K. Lichkus, E. Isikgel, M. C. Fahey, C. Ellaway   +7 more
wiley   +1 more source

Adolescent Exposure to a THC-Rich Cannabis Extract Produces Genotype-Dependent Effects on Cognition and Glial Morphology in Serine Racemase Mutant Mice. [PDF]

J Neurochem
Rangel IF, Chaves M, Pagnoncelli I, Medeiros I, Pinheiro F, Fortuna L, Castello-Branco L, Roch ED, Carvalho VM, Lima FRS, Panizzutti R, Romão L.   +11 more
europepmc   +1 more source

Assessment of Cannabidiol Supplements Use in Small Animals Practice in Portugal

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT This study aimed to assess the current use of cannabidiol supplements (CBDS) by Portuguese small animal veterinary practitioners. An anonymous online survey questioning the frequency of CBDS use, purpose of use and the perceived outcome was developed using Microsoft Forms, and targeted veterinarians currently working in small animal clinics in
Maria Inês Santos, Ana Luísa Lourenço
wiley   +1 more source

Psychotomimetic Cannabinoid Hyperlocomotion Involves GSK-3β Signaling at Striatopallidal Neurons in Male Mice. [PDF]

Biol Psychiatry Glob Open Sci
Tomaselli G, Bellocchio L, Raux PL, Roullot-Lacarrière V, Busquets-Garcia A, Lalanne V, Mariani Y, Cathala A, Zanese M, Cannich A, Grel A, Gisquet D, Mondesir M, Metna-Laurent M, Drutel G, Marsicano G, Piazza PV, Revest JM, Vallée M.   +18 more
europepmc   +1 more source

The viability of a standard THC unit [PDF]

Addiction, 2020
openaire   +2 more sources

Pharmacokinetics of Buccally Administered Cannabidiol and Oral Carprofen During Single‐ and Repeated‐Dose Administration in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Cannabidiol (CBD) is increasingly used as an adjunct treatment for chronic pain in dogs, but information on repeated‐dose pharmacokinetics and potential interactions with commonly used analgesics remains limited. This study evaluated the pharmacokinetics of buccally administered CBD, its major metabolites, and orally administered carprofen in ...
Tilen Vake, Katerina Tomsič, Žiga Žgank, Mihaela Klasić, Janja Babič, Zlatka Bajc, Jožica Dolenc, Gabrijela Tavčar Kalcher, Odon Planinšek, Tomaž Snoj   +9 more
wiley   +1 more source

Bedtime tetrahydrocannabinol ingestion reduces morning orthostatic cardiovascular reactivity in adults: An exploratory study. [PDF]

Physiol Rep
Gonzalez JE, Stewart AV, Robinson LD, Clemons NA, Ordaz OH, Emens JS, Thosar SS, Shea SA, Bowles NP.   +8 more
europepmc   +1 more source

THCS Website

The Partnership Website will be launched at M2 of the Partnership and it will include a public and private section.
openaire   +1 more source

Gap‐Free Cannabis sativa Assemblies Reveal Post‐Polyploid Genome Remodelling and Refine the Evolution of Cannabinoid Synthase Genes

Plant Biotechnology Journal, EarlyView.
ABSTRACT Despite the therapeutic importance of cannabinoids, the scarcity of gap‐free Cannabis genomes has limited the dissection of the genetic and genomic basis of cannabinoid biosynthesis and genome evolution. Here, we generated two haplotype‐phased, gap‐free, gold‐standard assemblies and used them to investigate post‐polyploid genome remodelling ...
Jiangjiang Zhang, Chuchu Qin, Zhao Li, Lining Zhao, Ashok Biswas, Touming Liu, Mingbao Luan, Lin Li, Defang Li, Jianbin Yan   +9 more
wiley   +1 more source

Elevated Levels of Blood Neurofilament Light Chain in Substance‐Using Populations: A Systematic Review and Meta‐Analysis

Psychiatry and Clinical Neurosciences, EarlyView.
Substance‐use disorders are increasingly linked to structural and functional brain alterations consistent with neuroaxonal injury. Neurofilament light chain (NfL) is a sensitive blood‐based marker of axonal damage, but evidence in substance‐using populations remains fragmented.
João Antônio Valadão Leal, Thiago Wendt Viola, Rodrigo Grassi‐Oliveira   +2 more
wiley   +1 more source