Results 91 to 100 of about 154,036 (328)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Power of High-precision Broadband Photometry: Tracing the Milky Way Density Profile with Blue Horizontal Branch Stars in the Dark Energy Survey

The Astrophysical Journal
Blue horizontal branch stars (BHBs), excellent distant tracers for probing the Milky Way’s halo density profile, are distinguished in the ${\left(g-r\right)}_{0}$ versus ( i − z ) _0 color space from another class of stars, blue straggler stars.
Fengqing Yu, Ting S. Li, Joshua S. Speagle, Gustavo E. Medina, Sergey E. Koposov, Joss Bland-Hawthorn, Lara R. Cullinane, Gwendolyn M. Eadie, Denis Erkal, Geraint F. Lewis, Guilherme Limberg, Daniel B. Zucker   +11 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Constraining the formation of the Milky Way: Ages

EPJ Web of Conferences, 2013
We present a new approach for studying the chemodynamical evolution of the Milky Way, which combines a thin disk chemical evolution model with the dynamics from N-body simulation of a galaxy with properties similar to those of our Galaxy.
Martig M., Minchev I., Chiappini C.
doaj   +1 more source

The imprint of bursty star formation on alpha-element abundance patterns in Milky Way-like galaxies [PDF]

, 2023
Hanna Parul, Jeremy Bailin, Andrew Wetzel, Alexander B. Gurvich, Claude‐André Faucher‐Giguère, Zachary Hafen, Jonathan Stern, Owain Snaith   +7 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Fermi-bubble Bulk and Edge Analysis Reveals Dust, Cooling Breaks, and Cosmic-Ray Diffusion, Facilitating a Self-consistent Model

The Astrophysical Journal
The full, radio to γ -ray spectrum of the Fermi bubbles is shown to be consistent with standard strong-shock electron acceleration at the bubble edge, without the unnatural energy cutoffs and unrealistic electron cooling of previous studies, if the ...
Uri Keshet, Ilya Gurwich, Assaf Lavi, Dina Avitan, Teodor Linnik   +4 more
doaj   +1 more source

TOWARD A UNIFICATION OF STAR FORMATION RATE DETERMINATIONS IN THE MILKY WAY AND OTHER GALAXIES [PDF]

, 2011
Laura Chomiuk, Matthew S. Povich
openalex   +1 more source