Results 111 to 120 of about 173,239 (326)
Gaussian Process Methods for Very Large Astrometric Data Sets
The Astrophysical JournalWe present a novel nonparametric method for inferring smooth models of the mean velocity field and velocity dispersion tensor of the Milky Way from astrometric data.
Timothy Hapitas +3 more
doaj +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
On the Formation of Planets in the Milky Way’s Thick Disk
The Astrophysical JournalExoplanet demographic surveys have revealed that close-in (≲1 au) small planets orbiting stars in the Milky Way’s thick disk are ∼50% less abundant than those orbiting stars in the Galactic thin disk.
Tim Hallatt, Eve J. Lee
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Shiva and Shakti: Presumed Proto-Galactic Fragments in the Inner Milky Way
The Astrophysical JournalUsing Gaia Data Release 3 astrometry and spectroscopy, we study two new substructures in the orbit–metallicity space of the inner Milky Way: Shakti and Shiva.
Khyati Malhan, Hans-Walter Rix
doaj +1 more source
A Bayesian Approach to the Vertical Structure of the Disk of the Milky Way
The Open Journal of Astrophysics, 2020 This work investigates the vertical profile of the stars in the disk of the Milky Way. The models investigated are of the form sech2/n(nz/(2H)) where, setting α = 2/n, the three functions of the sequence α= 0, 1, 2 correspond to exponential, sech, and ...
Phillip S. Dobbie , Stephen J. Warren
doaj +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
A Novel Approach to Identifying Substructures through Analysis of Metallicity Distribution Functions
The Astrophysical JournalWe present a new method for identifying Galactic halo substructures accreted from dwarf galaxies by combining metallicity distribution functions (MDFs) with orbital parameters.
Young Kwang Kim +2 more
doaj +1 more source
Lessons from the Milky Way: the Kapteyn Universe
, 2014 Jacobus Cornelius Kapteyn (1851-1922) presented a model for the distribution of stars in space together with a dynamical interpretation in terms of an equilibrium between the gravitational field of the stars and their random motion and rotation.
van der Kruit, P. C.
core +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source