Results 31 to 40 of about 154,036 (328)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

SF-R You Sure? The Conflicting Role of Star Formation Rates in Constraining the Evolution of Milky Way Analogs in Cosmological Simulations

The Astrophysical Journal
Milky Way analogs (MWAs) have long been studied by astronomers to place our Galaxy within an extragalactic context. With the power of cosmological simulations, we are now able to not only characterize MWAs today, but also watch as they evolve through ...
Alicia M. Savelli, Joshua S. Speagle, J. Ted Mackereth, Norman Murray, Kartheik G. Iyer   +4 more
doaj   +1 more source

HI shells in the outer Milky Way

, 2005
We present results of a method for an automatic search for HI shells in 3D data cubes and apply it to the Leiden-Dwingeloo HI survey of the northern Milky Way.
Ehlerova, S., Palous, J.
core   +1 more source

Testing modified Newtonian dynamics in the Milky Way [PDF]

, 2015
Modified Newtonian dynamics (MOND) is an empirical theory originally proposed to explain the rotation curves of spiral galaxies by modifying the gravitational acceleration, rather than by invoking dark matter.
Bertone, Gianfranco, Iocco, Fabio, Pato, Miguel   +2 more
core   +4 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Minimum-entropy Constraints on Galactic Potentials

The Astrophysical Journal
A tracer sample in a gravitational potential, starting from a generic initial condition, phase-mixes toward a stationary state. This evolution is accompanied by an entropy increase, and the final state is characterized by a distribution function (DF ...
Leandro Beraldo e Silva, Monica Valluri, Eugene Vasiliev, Kohei Hattori, Walter de Siqueira Pedra, Kathryne J. Daniel   +5 more
doaj   +1 more source

The Dark Disk of the Milky Way

, 2009
Massive satellite accretions onto early galactic disks can lead to the deposition of dark matter in disk-like configurations that co-rotate with the galaxy. This phenomenon has potentially dramatic consequences for dark matter detection experiments.
Bruch, Chris W. Purcell, Conroy, Gilmore, Gomez, Hammer, James S. Bullock, Jurić, Kazantzidis, Manoj Kaplinghat, Moster, Purcell, Purcell, Stewart, Widrow, Wyse   +15 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Synthetic Gaia DR3 Surveys from the FIRE Cosmological Simulations of Milky Way-mass Galaxies

The Astrophysical Journal
The third data release (DR3) of Gaia has provided a fivefold increase in the number of radial velocity measurements of stars, as well as a stark improvement in parallax and proper motion measurements.
Tri Nguyen, Xiaowei Ou, Nondh Panithanpaisal, Nora Shipp, Lina Necib, Robyn Sanderson, Andrew Wetzel   +6 more
doaj   +1 more source

The origin of the Milky Way globular clusters [PDF]

, 2016
We present a cosmological zoom-in simulation of a Milky Way-like galaxy used to explore the formation and evolution of star clusters. We investigate in particular the origin of the bimodality observed in the colour and metallicity of globular clusters ...
Agertz, Oscar, Gieles, Mark, Renaud, Florent   +2 more
core   +2 more sources