Results 131 to 140 of about 69,394 (286)
A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity
Advanced Science, EarlyView.We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong +6 morewiley +1 more sourceHomoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death
Advanced Science, EarlyView.Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen +12 morewiley +1 more sourceVersatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System
Advanced Science, EarlyView.This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin +13 morewiley +1 more sourceSuper‐Enhancer‐Driven SOX4/SMAD3 Mediate Membrane Remodeling by Regulating Phospholipid Metabolism to Accelerate Leukemia Progression
Advanced Science, EarlyView.Chronic myeloid leukemia blast phase (CML‐BP) poses a severe therapeutic challenge. This study reveals that the super‐enhancer‐driven transcription factors SOX4 and SMAD3 form a cooperative axis critical for disease progression. They co‐activate the oncogenic kinase AXL and promote phospholipid remodeling via LPCAT1 to facilitate its signaling ...Enzhe Lou, Peilong Lai, Guanjie Peng, Bo Lu, Lizhen Jiang, Xinyue Li, Jinghong Chen, Ladi Mo, Qiong Mao, Haichuan Zhang, Jinxin Fang, Yi Meng, Aochu Liu, Yingyin Gao, Andong Huang, Wenhui Lin, Shiwen Hu, Zerong Guan, Xiaolan Ye, Zhenguo Liu, Liling Jiang, Yueyuan Zheng, Xianping Shi +22 morewiley +1 more sourceThe Three-mm Ultimate Mopra Milky Way Survey. III. Data Release 6, An Atlas of Physical Conditions, Global Mass Conversion Laws, and 3D Physical Architecture of the Molecular Interstellar Medium in the Fourth Quadrant
The Astrophysical Journal Supplement SeriesAbstract We present Data Release 6 of ThrUMMS, consisting of complete data cubes and various moments of line emission (12CO, 13CO, C18O) from molecular clouds, across 60° × 2° of the Fourth Quadrant (4Q) of the Milky Way at a resolution of 72″ in (l, b) and 0.09 km s−1 in V LSR.Peter J. Barnes, Dylan G. H. Barnes, Audra K. Hernández, Sebastian Lopez, Erik Muller +4 moreopenaire +1 more sourceThe Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang +36 morewiley +1 more sourceMolecular Clouds Resolved at the Onset of Cosmic Noon
The Astrophysical Journal LettersWe present the discovery of seven molecular clouds in the radio galaxy B2 0902+34 at redshift z = 3.4. These clouds are detected as CO(0–1) absorption features against the bright radio continuum and spectrally resolved using the Karl G. Jansky Very Large Bjorn H. C. Emonts, Matthew D. Lehnert, Mingyu Li, Azia Robinson, Stephen J. Curran, Montserrat Villar-Martín, Chris L. Carilli, Raffaella Morganti, Ilsang Yoon, Pierre Guillard, George K. Miley, Reinout J. van Weeren, Zheng Cai +12 moredoaj +1 more sourceUnraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model
Advanced Science, EarlyView.Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing +5 morewiley +1 more sourceErratum to: Results from the search for dark matter in the Milky Way with 9 years of data of the ANTARES neutrino telescope? (Physics Letters B (2017) 769 (249?254), (S037026931730254X), (10.1016/j.physletb.2017.03.063))
, 2019 Limits on the neutrino flux for a given mass [Formula presented] and annihilation channel are calculated as in Eq. (7) (page 252), with the integrated acceptances defined in Eq. (8) (page 252) as the effective area averaged over the neutrino energy. A numerical approximation of WIMP annihilation spectra, adapted from [1] with a too coarse binning, led ...Albert A., Andre M., Anghinolfi M., Anton G., Ardid M., Aubert J. -J., Avgitas T., Baret B., Barrios-Marti J., Basa S., Bertin V., Biagi S., Bormuth R., Bourret S., Bouwhuis M. C., Bruijn R., Brunner J., Busto J., Capone A., Caramete L., Carr J., Celli S., Chiarusi T., Circella M., Coelho J. A. B., Coleiro A., Coniglione R., Costantini H., Coyle P., Creusot A., Deschamps A., De Bonis G., Distefano C., Di Palma I., Donzaud C., Dornic D., Drouhin D., Eberl T., El Bojaddaini I., Elsasser D., Enzenhofer A., Felis I., Fusco L. A., Galata S., Gay P., Geisselsoder S., Geyer K., Giordano V., Gleixner A., Glotin H., Gozzini R., Gregoire T., Gracia Ruiz R., Graf K., Hallmann S., van Haren H., Heijboer A. J., Hello Y., Hernandez-Rey J. J., Hossl J., Hofestadt J., Hugon C., Illuminati G., James C. W., de Jong M., Jongen M., Kadler M., Kalekin O., Katz U., Kiessling D., Kouchner A., Kreter M., Kreykenbohm I., Kulikovskiy V., Lachaud C., Lahmann R., Lefevre D., Leonora E., Lotze M., Loucatos S., Marcelin M., Margiotta A., Marinelli A., Martinez-Mora J. A., Mathieu A., Mele R., Melis K., Michael T., Migliozzi P., Moussa A., Mueller C., Nezri E., Pavalas G. E., Pellegrino C., Perrina C., Piattelli P., Popa V., Pradier T., Quinn L., Racca C., Riccobene G., Roensch K., Sanchez-Losa A., Saldana M., Salvadori I., Samtleben D. F. E., Sanguineti M., Sapienza P., Schnabel J., Schussler F., Seitz T., Sieger C., Spurio M., Stolarczyk T., Taiuti M., Tayalati Y., Trovato A., Tselengidou M., Turpin D., Tonnis C., Vallage B., Vallee C., Van Elewyck V., Vivolo D., Vizzoca A., Wagner S., Wilms J., Zornoza J. D., Zuniga J. +128 moreopenaire +5 more sourcesEndocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore +20 morewiley +1 more source
