Results 141 to 150 of about 69,394 (286)

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

The Three-mm Ultimate Mopra Milky Way Survey. III. Data Release 6, An Atlas of Physical Conditions, Global Mass Conversion Laws, and 3D Physical Architecture of the Molecular ISM in the Fourth Quadrant

Replaced with accepted version for ApJS, after modest revisions. Main paper 16 pages, 11 figures. Appendix A 15 pages, 11 figures. Appendix B 11 pages, 10 figures.
Barnes, Peter J., Barnes, Dylan G. H., Hernandez, Audra K., Lopez, Sebastian, Muller, Erik   +4 more
openaire   +2 more sources

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Discovery and Spectroscopic Confirmation of Aquarius III: A Low-mass Milky Way Satellite Galaxy

The Astrophysical Journal
We present the discovery of Aquarius III, an ultra-faint Milky Way satellite galaxy identified in the second data release of the DECam Local Volume Exploration survey.
W. Cerny, A. Chiti, M. Geha, B. Mutlu-Pakdil, A. Drlica-Wagner, C. Y. Tan, M. Adamów, A. B. Pace, J. D. Simon, D. J. Sand, A. P. Ji, T. S. Li, A. K. Vivas, E. F. Bell, J. L. Carlin, J. A. Carballo-Bello, A. Chaturvedi, Y. Choi, A. Doliva-Dolinsky, O. Y. Gnedin, G. Limberg, C. E. Martínez-Vázquez, S. Mau, G. E. Medina, M. Navabi, N. E. D. Noël, V. M. Placco, A. H. Riley, I. U. Roederer, G. S. Stringfellow, C. R. Bom, P. S. Ferguson, D. J. James, D. Martínez-Delgado, P. Massana, D. L. Nidever, J. D. Sakowska, L. Santana-Silva, N. F. Sherman, E. J. Tollerud, DELVE Collaboration   +40 more
doaj   +1 more source

Mapping dark matter in the Milky Way, a synopsis

, 2015
Mapping the dark matter distribution across our Galaxy represents a central challenge for the near future as a new generation of space-borne and ground-based astronomical surveys swiftly comes online.
Iocco, Fabio, Pato, Miguel
core  

VE‐Cadherin–Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension‐Sensitive Intermediate State

Advanced Science, EarlyView.
This study investigates how endothelial monolayers balance cohesion and plasticity during mechanical stimulation. In HUVECs, shear stress induces a tension‐sensitive intermediate state in which junctional VE‐cadherin and actomyosin relaxation levels coordinate actin/integrin remodeling. This rapid, reversible state strengthens cell junctions, preserves
Jonas Franz, Maria Odenthal‐Schnittler, Jan Philip Kipcke, Jochen Seebach, Zahra Labbaf, Franziska Merten, Vesna Bojovic, Muna Taha, Johannes A. Eble, Erez Raz, Milos Galic, Hans Schnittler   +11 more
wiley   +1 more source

The Effects of Linear Matter Power Spectrum Enhancement on Dark Matter Substructure

The Astrophysical Journal
We present cosmological dark matter (DM)–only zoom-in simulations of a Milky Way analog originating from enhanced linear matter power spectra P ( k ) relative to the standard cold, collisionless DM (CDM) cosmology.
Ethan O. Nadler, Vera Gluscevic, Andrew Benson   +2 more
doaj   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source

Cosmic Rays Masquerading as Hot CGM Gas: An Inverse-Compton Origin for Diffuse X-ray Emission in the Circumgalactic Medium

The Open Journal of Astrophysics
Observations from _ROSAT_ and _eROSITA_ have argued that Milky Way (MW), Andromeda, and lower-mass galaxies exhibit extended soft X-ray ($1\,$keV) diffuse halos out to radii $R\gtrsim 100\,$kpc in the circumgalactic medium (CGM).
Philip F. Hopkins, Eliot Quataert, Sam B. Ponnada, Emily Silich   +3 more
doaj   +1 more source

Protection and Delivery of Phytochemicals from Passive Encapsulation to Guaranteed Self‐Assembly Induced by Amyloid Template for Chronic Disease Prevention via Modulating Microbial‐Host Crosstalk

Advanced Science, EarlyView.
ABSTRACT The rising incidence of chronic diseases globally has drawn widespread attention to phytochemicals, which exert targeted preventive and alleviating effect by modulating gut microbiota; thus, a potential strategy for precision nutritional interventions is offered.
Shiqi Bai, Siying Cheng, Fengguang Ma, Xiaorong Zhang, Jianan Huang, Zhonghua Liu, Bing Hu   +6 more
wiley   +1 more source