Results 151 to 160 of about 1,919 (204)

The nitration of thebaine with tetranitromethane

Journal of the Chemical Society, Perkin Transactions 1, 1981
Thebaine (1) reacts in methanol with tetranitromethane to give, as the major product, 14β-nitrocodeinone dimethyl acetal (2a), which has been converted into, inter alia, 14β-nitrocodeinone (3a), 14β-aminocodeinone dimethyl acetal (2b), 14β-aminocodeinone (3b), and 14β-aminocodeine.
Robert M. Allen, Gordon W. Kirby, David J. McDougall   +2 more
openaire   +1 more source

The pharmacology of thebaine in the chronic spinal dog

Drug and Alcohol Dependence, 1978
The effects of thebaine were studied in nondependent and morphine-dependent chronic spinal dogs as well as in chronic spinal dogs receiving thebaine chronically. Thebaine did not produce any morphine-like effects in nondependent dogs nor did it precipitate an abstinence syndrome in morphine-dependent dogs.
P E, Gilbert, W R, Martin
openaire   +2 more sources

Thebaine Adducts with Maleimides. Synthesis and Transformations.

ChemInform, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
E.E. Shults, M.M. Shakirov, G.A. Tolstikov, V.N. Kalinin, G. Schmidhammer   +4 more
openaire   +1 more source

ChemInform Abstract: THEBAINE AND ACETYLENIC DIENOPHILES

Chemischer Informationsdienst, 1982
AbstractThebain (1) reagiert mit Propiolsäuremethylester (II) in Methanol zu den beiden Addukten(I1I) und (IV).
A. SINGH, S. ARCHER, K. HOOGSTEEN, J. HIRSHFIELD   +3 more
openaire   +1 more source

Cyclo-adducts of thebaine with nitrosoarenes

Journal of the Chemical Society, Perkin Transactions 1, 1979
Thebaine (1) reacts reversibly with various nitroso-arenes to form cyclo-adducts by 1,4-addition of the nitrosogroup to the conjugated diene system of the alkaloid. Adducts (2) of thebaine with nitrosobenzene and with 4-chloro-, 4-methyl-, 3-methoxy-, and 4-nitro-nitrosobenzene have been prepared in good yield.
Gordon W. Kirby, Kenneth W. Bentley, Peter Horsewood, Serjinder Singh   +3 more
openaire   +1 more source

Study on Synthesis of Thebaine Derivatives

Chinese Journal of Chemistry, 2005
The reaction of 7α-acetyl-6,14-endoethano-6,7,8,14-tetrahydrothebaine with 2-(thien-2-yl)ethylmagnesium bromide was investigated. The tertiary alcohol derivative 7α-[R-1-hydroxyl-1-methyl-3-(thien-2-yl)propyl])-6,14-endoethano-6,7,8,14-tetrahydrothebaine (3) and a by-product 4 were isolated. The structure of 4 was elucidated by X-ray analysis.
He Liu, Chun-He Liu, Bo Wu, Bo-Hua Zhong, Ze-Hui Gong   +4 more
openaire   +1 more source

Reaction of thebaine with dinitrogen tetroxide

Journal of Heterocyclic Chemistry, 1979
AbstractTreatment of thebaine with dinitrogen tetroxide gave a mixture of 14β‐nitrocodeinone (23%) and 8‐nitrothebaine (7%).
Sydney Archer, Peter Osei‐Gyimah
openaire   +1 more source

Colorimetric Determination of Thebaine in Papauer Bracteatum

Journal of Pharmaceutical Sciences, 1981
A rapid colorimetric test for the determination of thebaine in dried, extracted Papaver bracteatum is described. The method is based on the development of an orange color formed by the nitroso color reaction for phenols. The absorption peak is near 450 nm. The linear range response is from 0 to 1.0 mg of thebaine.
openaire   +2 more sources

Pharmacokinetics and Metabolism of [³H] Thebaine

Xenobiotica, 1974
1. A method is described for determination of [3H]thebaine in biological materials with sensitivity of 10–20 ng.2. Following a 5 mg/kg subcutaneous dose of [3H]thebaine to rats, max. brain and plasma concns. were 937 ng/g and 1076 ng/ml at 0.5 and 1 h, respectively; these declined to non-detectable levels at 24 h.
A L, Misra, R B, Pontani, S J, Mulé
openaire   +2 more sources

Studies on thebaine, III. Oxidative colorimetric analysis of thebaine

Archiv der Pharmazie, 1985
O F, Ellingsen, K E, Malterud, J K, Wold
openaire   +2 more sources