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Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches
Frontiers in Endocrinology, 2022 The pathological condition of insulin resistance prevents the neuroprotective effects of insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk factor for ischemic stroke, accelerates the formation of thrombosis and ...
Peng-Fei Ding +11 more
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Colorectal Cancer: Therapeutic Approaches and Their Complications [PDF]
BiomedicinesColorectal cancer (CRC) is ranked as the third most lethal of all cancers in the USA, following prostate and lung malignancy in men, and breast and lung malignancy in women, respectively.
Adebisi Adeleke +4 more
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European Journal of Histochemistry, 2022 Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. Despite progress in the last decades, there are still no reliable biomarkers for the diagnosis of and prognosis for GC.
Michael W.L. Quirino +7 more
doaj +1 more source
FUCA2 and TSTA3 expression in gastric cancer: candidate biomarkers of malignant transformation
Folia Histochemica et Cytobiologica, 2022 INTRODUCTION: Aberrant fucosylation is closely related to malignant transformation, cancer detection, and evaluation of treatment efficacy. The fucosylation process requires GDP-L-fucose, fucosyltransferases, and fucosidases.
Michael Williames Leal Quirino +7 more
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APOE and Alzheimer’s Disease: Advances in Genetics, Pathophysiology, and Therapeutic Approaches.
Lancet Neurology, 2021 SUMMARY The APOE ε4 allele remains the strongest genetic risk factor for sporadic Alzheimer’s disease and the APOE ε2 allele the strongest genetic protective factor after multiple large scale genome-wide association studies and genome-wide association ...
A. Serrano‐Pozo +2 more
semanticscholar +1 more source
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Signal Transduction and Targeted Therapy, 2023 Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in which the airways narrow or collapse during sleep, causing obstructive sleep apnea.
Renjun Lv +7 more
semanticscholar +1 more source
Current and emerging therapeutic approaches for colorectal cancer: A comprehensive review
World Journal of Gastrointestinal Surgery, 2023 Colorectal cancer (CRC) affects 1 in 23 males and 1 in 25 females, making it the third most common cancer. With roughly 608000 deaths worldwide, CRC accounts for 8% of all cancer-related deaths, making it the second most common cause of death due to ...
Anil Kumar +5 more
semanticscholar +1 more source
Gut microbiota in the pathogenesis and therapeutic approaches of diabetes
EBioMedicine, 2023 Summary The gut–liver axis plays a prominent role in the pathogenesis and therapy of metabolic diseases such as diabetes. The intestinal specific origin of several hormones that guide both inter- and post-prandial metabolism of carbohydrates and lipids ...
L. Crudele +3 more
semanticscholar +1 more source
Development, Characterization, and Immunomodulatory Evaluation of Carvacrol-loaded Nanoemulsion
Molecules, 2021 Carvacrol (CV) is an essential oil with numerous therapeutic properties, including immunomodulatory activity. However, this effect has not been studied in nanoemulsion systems.
Amanda Gabrielle Barros Dantas +6 more
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Frontiers in Oncology, 2022 Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer.
T. Emran +15 more
semanticscholar +1 more source