Results 31 to 40 of about 18,121,732 (293)

The total terpenoids of (TTC) inhibit NOX-dependent formation of PMA-induced neutrophil extracellular traps (NETs)

European Journal of Inflammation, 2018
Previously, we identified that Celastrus orbiculatus , a traditional Chinese herbal medicine, exhibited prominent anti-inflammatory and anti-tumor activities.
Li Tao, Min Xu, Yanqing Liu
doaj   +1 more source

Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives

Frontiers in Molecular Biosciences, 2021
Coronavirus disease (COVID-19) has emerged as a fast-paced epidemic in late 2019 which is disrupting life-saving immunization services. SARS-CoV-2 is a highly transmissible virus and an infectious disease that has caused fear among people across the ...
K. Vivekanandhan, Poornima Shanmugam, H. Barabadi, V. Arumugam, Dharun Daniel Raj Daniel Paul Raj, Manikandan Sivasubramanian, Subbaiya Ramasamy, K. Anand, P. Boomi, B. Chandrasekaran, S. Arokiyaraj, M. Saravanan   +11 more
semanticscholar   +1 more source

Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches

Pediatric Rheumatology Online Journal, 2021
Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatological disorder and is classified by subtype according to International League of Associations for Rheumatology criteria.
L. Zaripova, A. Midgley, S. Christmas, M. Beresford, E. Baildam, Rachel A. Oldershaw   +5 more
semanticscholar   +1 more source

Osteosarcoma: a review of current and future therapeutic approaches

BioMedical Engineering OnLine, 2021
Osteosarcoma (OS) is the most common primary bone malignancy that affects children and young adults. OS is characterized by a high degree of malignancy, strong invasiveness, rapid disease progression, and extremely high mortality rate; it is considered ...
Xin Zhao, Qirui Wu, Xiuqing Gong, Jinfeng Liu, Yujie Ma   +4 more
semanticscholar   +1 more source

SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches

MedComm – Future Medicine, 2022
The coronavirus disease 2019 (COVID‐19) is a global infectious disease aroused by RNA virus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).
Mingming Wang, Yue Zhao, Juan Liu, Ting Li   +3 more
doaj   +1 more source

CASPASE-3 expression and activity in PBMCs associate with SARS-CoV-2 infection and clinical features

Clinical Immunology Communications
Background: Although vaccines and treatments exist, new SARS-CoV-2 variants continue to emerge. An imbalance between apoptosis and autophagy may contribute to COVID-19 pathogenesis, leading to tissue damage and inflammation. Objective: To investigate the
Vanessa Mylenna Florêncio de Carvalho, Bárbara de Oliveira Silva, Priscilla Stela Santana de Oliveira, Thacianna Barreto da Costa, Michelle Melgarejo da Rosa, Moacyr Jesus Barreto de Melo Rêgo, Michelly Cristiny Pereira, Maira Galdino da Rocha Pitta   +7 more
doaj   +1 more source

Ubiquitination and deubiquitination in cancer: from mechanisms to novel therapeutic approaches

Molecular Cancer
Ubiquitination, a pivotal posttranslational modification of proteins, plays a fundamental role in regulating protein stability. The dysregulation of ubiquitinating and deubiquitinating enzymes is a common feature in various cancers, underscoring the ...
Fangfang Liu, Jingyu Chen, Kaiyuan Li, Haocheng Li, Yiyi Zhu, Yubo Zhai, Bingbing Lu, Yanle Fan, Ziyue Liu, Xiaojie Chen, X. Jia, Zigang Dong, Kangdong Liu   +12 more
semanticscholar   +1 more source

Confusion of Therapeutic Approaches [PDF]

Deutsches Ärzteblatt international, 2014
Schlitt et al. in their review article focused on cardiotoxic oncological treatments (1). Adequate management of adverse effects of cardiotoxic treatments ensures optimal results of oncological treatment. In the article by Schlitt et al., an algorithm was proposed for monitoring, prevention, and treatment in the context of cardiotoxicity, including the
Ivanyi, Philipp, Grünwald, Viktor, Steffens, Sandra   +2 more
openaire   +2 more sources

Neurodegenerative Disorders: Mechanisms of Degeneration and Therapeutic Approaches with Their Clinical Relevance.

Ageing Research Reviews
Neurodegenerative disorders (NDs) are expected to pose a significant challenge for both medicine and public health in the upcoming years due to global demographic changes.
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, S. Jha, S. Nangare, Gaurav Gupta, S. Singh, Kamal Dua, Hyunah Cho, P. Hansbro, K. Paudel   +9 more
semanticscholar   +1 more source

Key Players in HIV-1 Transcriptional Regulation: Targets for a Functional Cure

Viruses, 2020
HIV-1 establishes a life-long infection when proviral DNA integrates into the host genome. The provirus can then either actively transcribe RNA or enter a latent state, without viral production.
Luisa Mori, Susana T. Valente
doaj   +1 more source