Results 1 to 10 of about 1,046,320 (355)
Therapeutic drug monitoring in drug overdose [PDF]
British Journal of Clinical Pharmacology, 2001 The treatment of poisoned patients is still largely defined by history, clinical assessment and interpretation of ancillary investigations. Measurement of drug concentrations is clinically important for relatively few compounds. Most measurements form an adjunct to and should not be considered a substitute for clinical assessment.
Andrew H. Dawson, Ian M. Whyte
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Therapeutic drug monitoring – antiepileptic drugs [PDF]
British Journal of Clinical Pharmacology, 2001 Aims To provide a brief critical review of the basis and contemporary practice of monitoring the concentrations of antiepileptic drugs in biological fluids. Methods The review is based on literature data and observations from clinical practice.
M. J. Eadie
+12 more sources
Therapeutic drug monitoring of imatinib [PDF]
Revista Brasileira de Hematologia e Hemoterapia, 2011 In this issue of the Revista Brasileira de Hematologia e Hemoterapia, Martins et al.(1) are publishing an interesting review, a meta-analysis, of the clinical and analytical aspects of therapeutic drug monitoring of imatinib in chronic myeloid leukemia (CML). Imatinib, the archetype for tyrosine kinase inhibitor therapeutics, is an excellent example
Pierre Wallemacq
doaj +7 more sources
Therapeutic drug monitoring of cytotoxic drugs [PDF]
British Journal of Clinical Pharmacology, 2001 Therapeutic drug monitoring is not routinely used for cytotoxic agents. There are several reasons, but one major drawback is the lack of established therapeutic concentration ranges. Combination chemotherapy makes the establishment of therapeutic ranges for individual drugs difficult, the concentration‐effect relationship for a single drug may not be ...
Lynne Lennard
+8 more sources
Therapeutic drug monitoring: antiarrhythmic drugs [PDF]
British Journal of Clinical Pharmacology, 2001 Antiarrhythmic agents are traditionally classified according to Vaughan Williams into four classes of action. Class I antiarrhythmic agents include most of the drugs traditionally thought of as antiarrhythmics, and have as a common action, blockade of the fast‐inward sodium channel on myocardium. These agents have a very significant toxicity, and while
T. J. Campbell, K. M. Williams
openalex +7 more sources
Therapeutic drug monitoring of immunosuppressant drugs [PDF]
British Journal of Clinical Pharmacology, 1999 Individualizing a patient’s drug therapy to obtain the optimum balance between therapeutic efficacy and the occurrence of adverse events is the physician’s goal. However, achieving this goal is not always straight forward, being complicated by within and between patient variability in both pharmacokinetics and pharmacodynamics.
A. E. Johnston, David W. Holt
openalex +4 more sources
On-Site Therapeutic Drug Monitoring. [PDF]
Trends in Biotechnology, 2020 Recent technological advances have stimulated efforts to bring personalized medicine into practice. Yet, traditional application fields like therapeutic drug monitoring (TDM) have remained rather under-appreciated. Owing to clear dose-response relationships, TDM could improve patient outcomes and reduce healthcare costs.
H. Ates +7 more
semanticscholar +5 more sources
Therapeutic Drug Monitoring of Antiepileptic Drugs
Journal of Nepal Medical Association, 2008 Commonly used conventional antiepileptic drugs for pharmacotherapy in epilepsy are phenytoin, carbamazepine and valproic acid. These drugs have complex pharmacokinetic properties leading to fluctuation in their plasma level at given same therapeutic dose.
Geeta Shakya +3 more
doaj +5 more sources
Therapeutic Drug Monitoring and Pharmacokinetics-Based Individualization of Drug Therapy [PDF]
PharmaceuticsThe philosophy, practice, and clinical impact of therapeutic drug monitoring (TDM) has changed profoundly with the appearance of widely available and, in a technical sense, commonly applicable modeling, simulation, and dosing software tools in the past ...
Gellert Balazs Karvaly +1 more
doaj +2 more sources
Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
Clinical Pharmacokinetics, 2023 Although kinase inhibitors (KI) frequently portray large interpatient variability, a ‘one size fits all’ regimen is still often used. In the meantime, relationships between exposure-response and exposure-toxicity have been established for several KIs, so
Maud B A van der Kleij +6 more
semanticscholar +1 more source