Results 11 to 20 of about 1,472,669 (399)
Total and Unbound Pharmacokinetics of Cefiderocol in Critically Ill Patients
Pharmaceutics, 2022 Background: Cefiderocol is a siderophore cephalosporin antibiotic active against Gram-negative bacteria, including extended-spectrum beta-lactamase and carbapenemase-producing strains.
Noël Zahr +11 more
doaj +1 more source
Biosensors, 2023 Precision medicine, particularly therapeutic drug monitoring (TDM), is essential for optimizing drug dosage and minimizing toxicity. However, current TDM methods have limitations, including the need for skilled operators, patient discomfort, and the ...
Yuqiao Liu +7 more
semanticscholar +1 more source
Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
Clinical Pharmacokinetics, 2023 Although kinase inhibitors (KI) frequently portray large interpatient variability, a ‘one size fits all’ regimen is still often used. In the meantime, relationships between exposure-response and exposure-toxicity have been established for several KIs, so
Maud B. A. van der Kleij +6 more
semanticscholar +1 more source
Toward therapeutic drug monitoring of citalopram in depression? Insights from a systematic review
Frontiers in Psychiatry, 2023 BackgroundWithin the framework of individualized psychopharmacotherapy, therapeutic drug monitoring (TDM) has gained increasing relevance. In the absence of high-quality evidence, the TDM of citalopram (CIT) and the recommended therapeutic ranges of the ...
Na Xu +10 more
doaj +1 more source
European journal of drug metabolism and pharmacokinetics, 2023 This review provides an overview on the current applications of dried blood spots (DBS) as matrices for therapeutic drug (TDM) and drug or disease response monitoring (DRM).
Nur Nabihah Binte Zailani, P. Ho
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Objective: Continuous lenalidomide (LEN) therapy is important to achieve a therapeutic effect in patients with multiple myeloma (MM) and non-Hodgkin lymphoma (NHL).
Zaiwei Song +18 more
doaj +1 more source
From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics
Clinical pharmacology and therapy, 2021 Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have evolved as important tools to inform rational dosing of antibiotics in individual patients with infections.
S. Wicha +6 more
semanticscholar +1 more source
Pharmaceutics, 2022 Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM), we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical questions were selected.
Kazuaki Matsumoto +11 more
semanticscholar +1 more source
American Journal of Gastroenterology, 2021 Therapeutic drug monitoring (TDM) of biologics is a rapidly evolving field. We aimed to provide a consensus statement regarding the clinical utility of TDM for biologics in inflammatory bowel disease (IBD). A modified Delphi method was applied to develop
A. Cheifetz +11 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2023 In the treatment of pain, especially chronic pain, the rule of multimodal therapy applies, based on various painkillers mechanisms of action. The aim of the conducted study was to evaluate the in vitro penetration of ketoprofen (KET) and lidocaine ...
Urszula Adamiak-Giera +10 more
doaj +1 more source