Results 11 to 20 of about 1,437,202 (311)

Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#

Intensive Care Medicine, 2020
This Position Paper aims to review and discuss the available data on therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill adult patients in the intensive care unit (ICU).
M. Abdul-Aziz, J. Alffenaar, M. Bassetti, H. Bracht, G. Dimopoulos, D. Marriott, M. Neely, J. Paiva, F. Pea, F. Sjovall, J. Timsit, A. Udy, S. Wicha, M. Zeitlinger, J. D. De Waele, J. Roberts   +15 more
semanticscholar   +1 more source

A Comprehensive Literature Review and Expert Consensus Statement on Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease

American Journal of Gastroenterology, 2021
Therapeutic drug monitoring (TDM) of biologics is a rapidly evolving field. We aimed to provide a consensus statement regarding the clinical utility of TDM for biologics in inflammatory bowel disease (IBD). A modified Delphi method was applied to develop
A. Cheifetz, M. Abreu, W. Afif, R. Cross, M. Dubinsky, E. Loftus, M. Osterman, Ariana Saroufim, C. Siegel, A. Yarur, G. Melmed, K. Papamichael   +11 more
semanticscholar   +1 more source

Bayesian data assimilation to support informed decision-making in individualized chemotherapy [PDF]

, 2020
An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes.
de Wiljes, Jana, Hartung, Niklas, Huisinga, Wilhelm, Kloft, Charlotte, Maier, Corinna   +4 more
core   +2 more sources

Microneedle Aptamer-Based Sensors for Continuous, Real-Time Therapeutic Drug Monitoring

Analytical Chemistry, 2022
The ability to continuously monitor the concentration of specific molecules in the body is a long-sought goal of biomedical research. For this purpose, interstitial fluid (ISF) was proposed as the ideal target biofluid because its composition can rapidly
Yao Wu, Farshad Tehrani, H. Teymourian, John Mack, Alexander Shaver, Maria Reynoso, Jonathan Kavner, Nickey Huang, Allison Furmidge, Andrés Duvvuri, Yuhang Nie, Lori M. Laffel, Francis J. Doyle, M. Patti, Eyal Dassau, Joseph Wang, N. Arroyo‐Currás   +16 more
semanticscholar   +1 more source

Individualized immunosuppression in transplant patients: potential role of pharmacogenetics. [PDF]

, 2012
The immunosuppressive drugs used to prevent the rejection of transplanted organs have a narrow therapeutic index. Under treatment results in episodes of rejection leading to either damage or loss of the organ. Over immunosuppression increases the risk of
Abboudi, H, Macphee, IA
core   +2 more sources

Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance Proactive therapeutic drug monitoring (TDM), defined as individualized drug dosing based on scheduled monitoring of serum drug levels, has been proposed as an alternative to standard therapy to maximize efficacy and safety of infliximab and ...
S. W. Syversen, G. Goll, K. Jørgensen, Ø. Sandanger, J. Sexton, Inge Christoffer Olsen, J. Gehin, D. Warren, M. K. Brun, R. Klaasen, L. Karlsen, G. Noraberg, C. Zettel, M. Ljoså, A. Haugen, Rune Johan Njålla, T. J. Bruun, K. A. Seeberg, B. Michelsen, E. K. Strand, S. Skorpe, I. Blomgren, Y. Bragnes, C. Dotterud, T. Thune, C. Ystrøm, R. Torp, P. Mielnik, C. Mork, T. Kvien, J. Jahnsen, N. Bolstad, E. Haavardsholm   +32 more
semanticscholar   +1 more source

Therapeutic Drug Monitoring and Methods of Quantitation for Carbamazepine [PDF]

, 2017
Carbamazepine is an early anticonvulsant still used today in the treatment of several forms of epilepsy. An active metabolite in the human body contributes to its pharmacological effect.
Ana Vlasceanu, Cristian Balalau, Cristian Tuchila, Cristina Pirvu, Daniela Baconi, Denisa Balalau, Miriana Stan, null null   +7 more
core   +4 more sources

Therapeutic Drug Monitoring of Ganciclovir: Where Are We?

Therapeutic Drug Monitoring, 2021
Background: Ganciclovir is the mainstay of therapy for the prophylaxis and treatment of Cytomegalovirus. However, therapy with this antiviral agent is hindered by side effects such as myelosuppression, which often leads to therapy cessation. Underdosing,
A. Märtson, A. E. Edwina, H. Kim, M. Knoester, D. Touw, M. Sturkenboom, J. Alffenaar   +6 more
semanticscholar   +1 more source

Everolimus dosing recommendations for tuberous sclerosis complex–associated refractory seizures [PDF]

, 2018
ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study ...
Brandt, Christian, Cheung, Wing, Coello, Neva, Franz, David N, French, Jacqueline A, Grosch, Kai, Kohrman, Michael H, Lawson, John A, Milh, Mathieu, Voi, Maurizio, Wiemer-Kruel, Adelheid, Wong, Michael, Yapici, Zuhal   +12 more
core   +2 more sources

Immunsuppressiva-Medikamentenspiegelmessung – reine Routine? / Immunosuppressant drug monitoring – a routine undertaking? [PDF]

, 2010
The quantitative assessment of immunosuppressant drug levels is still one of the most challenging therapeutic drug monitoring procedures in clinical routine. During the past years, several technical developments matured to useable methods. In addition to
Seger, Christoph, Vogeser, Michael
core   +1 more source