Results 21 to 30 of about 1,046,320 (355)

Optimizing Therapies Using Therapeutic Drug Monitoring: Current Strategies and Future Perspectives.

Gastroenterology, 2022
Therapeutic drug monitoring (TDM) has emerged as a strategy for treatment optimization in inflammatory bowel diseases in order to maximise benefit and to reach more stringent, objective endpoints.
P. Irving, K. Gecse
semanticscholar   +1 more source

Toward Therapeutic Drug Monitoring of Lenalidomide in Hematological Malignancy? Results of an Observational Study of the Exposure-Safety Relationship

Frontiers in Pharmacology, 2022
Objective: Continuous lenalidomide (LEN) therapy is important to achieve a therapeutic effect in patients with multiple myeloma (MM) and non-Hodgkin lymphoma (NHL).
Zaiwei Song, Zaiwei Song, Lan Ma, Li Bao, Yi Ma, Yi Ma, Ping Yang, Ping Yang, Dan Jiang, Dan Jiang, Aijun Liu, Lu Zhang, Yan Li, Yinchu Cheng, Yinchu Cheng, Fei Dong, Rongsheng Zhao, Rongsheng Zhao, Hongmei Jing   +18 more
doaj   +1 more source

From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics

Clinical pharmacology and therapy, 2021
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have evolved as important tools to inform rational dosing of antibiotics in individual patients with infections.
S. Wicha, A. Märtson, E. Nielsen, B. Koch, L. Friberg, J. Alffenaar, Iris K. Minichmayr   +6 more
semanticscholar   +1 more source

Expert consensus statement on therapeutic drug monitoring and individualization of linezolid

Frontiers in Public Health, 2022
Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring and individualized treatment have been challenged since its approval.
B. Lin, Yangmin Hu, P. Xu, Tao Xu, Chunyan Chen, Lei He, Mi Zhou, Z. Chen, Chunhong Zhang, Xuben Yu, L. Fang, Junfeng Zhu, Y. Ji, Qun Lin, He-qiong Cao, You-Jun Dai, Xiaoyan Lu, Changcheng Shi, Li Li, Changjiang Wang, Xumei Li, Qi Fang, Jing Miao, Zhengyi Zhu, Guangyong Lin, Haichao Zhan, Shiwen Lv, Yalan Zhu, Xin-jun Cai, Yinqing Ying, Meng Chen, Qiong Xu, Yiwen Zhang, Yubin Xu, Pea Federico, Saiping Jiang, Haibin Dai   +36 more
semanticscholar   +1 more source

Evaluation of the in vitro permeation parameters of topical ketoprofen and lidocaine hydrochloride from transdermal Pentravan® products through human skin

Frontiers in Pharmacology, 2023
In the treatment of pain, especially chronic pain, the rule of multimodal therapy applies, based on various painkillers mechanisms of action. The aim of the conducted study was to evaluate the in vitro penetration of ketoprofen (KET) and lidocaine ...
Urszula Adamiak-Giera, Anna Nowak, Wiktoria Duchnik, Paula Ossowicz-Rupniewska, Anna Czerkawska, Anna Machoy-Mokrzyńska, Tadeusz Sulikowski, Łukasz Kucharski, Marta Białecka, Adam Klimowicz, Monika Białecka   +10 more
doaj   +1 more source

A Comprehensive Literature Review and Expert Consensus Statement on Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease

American Journal of Gastroenterology, 2021
Therapeutic drug monitoring (TDM) of biologics is a rapidly evolving field. We aimed to provide a consensus statement regarding the clinical utility of TDM for biologics in inflammatory bowel disease (IBD). A modified Delphi method was applied to develop
A. Cheifetz, M. Abreu, W. Afif, R. Cross, M. Dubinsky, E. Loftus, M. Osterman, Ariana Saroufim, C. Siegel, A. Yarur, G. Melmed, K. Papamichael   +11 more
semanticscholar   +1 more source

Systematic review and meta-analysis on the therapeutic reference range for escitalopram: Blood concentrations, clinical effects and serotonin transporter occupancy

Frontiers in Psychiatry, 2022
IntroductionA titration within a certain therapeutic reference range presupposes a relationship between the blood concentration and the therapeutic effect of a drug. However, this has not been systematically investigated for escitalopram.
Luzie Eichentopf, Christoph Hiemke, Christoph Hiemke, Andreas Conca, Andreas Conca, Jan Engelmann, Manfred Gerlach, Manfred Gerlach, Ursula Havemann-Reinecke, Ursula Havemann-Reinecke, Gudrun Hefner, Gudrun Hefner, Vincenzo Florio, Maxim Kuzin, Maxim Kuzin, Klaus Lieb, Margareta Reis, Margareta Reis, Thomas G. Riemer, Alessandro Serretti, Georgios Schoretsanitis, Georgios Schoretsanitis, Georgios Schoretsanitis, Georgios Schoretsanitis, Gerald Zernig, Gerald Zernig, Gerald Zernig, Gerhard Gründer, Gerhard Gründer, Xenia M. Hart, Xenia M. Hart   +30 more
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Arterial Blood Pressure Variability and Other Vascular Factors Contribution to the Cognitive Decline in Parkinson’s Disease

Molecules, 2021
Dementia is one of the most disabling non-motor symptoms in Parkinson’s disease (PD). Unlike in Alzheimer’s disease, the vascular pathology in PD is less documented.
Anna Pierzchlińska, Magdalena Kwaśniak-Butowska, Jarosław Sławek, Marek Droździk, Monika Białecka   +4 more
doaj   +1 more source

Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#

Intensive Care Medicine, 2020
This Position Paper aims to review and discuss the available data on therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill adult patients in the intensive care unit (ICU).
M. Abdul-Aziz, J. Alffenaar, M. Bassetti, H. Bracht, G. Dimopoulos, D. Marriott, M. Neely, J. Paiva, F. Pea, F. Sjovall, J. Timsit, A. Udy, S. Wicha, M. Zeitlinger, J. D. De Waele, J. Roberts   +15 more
semanticscholar   +1 more source

Rosemary and CoQ10 Alleviated the Detrimental Effects of Concomitant Administration of Acetaminophen and Carbamazepine by Accelerating Their Metabolism and Elimination

Indonesian Biomedical Journal, 2022
BACKGROUND: The interaction of carbamazepine (CBZ) and acetaminophen (APAP) could result in hepatic failure and mortality. This study was conducted to analyzed the potential of rosemary ethanol extract (REE) or coenzyme Q10 (CoQ10) to alleviate the ...
Marwa Magdy Hamido, Nashwah Ismail Zaki, Sawsan Ahmed Nasr, Wael Mohamed El-Sayed   +3 more
doaj   +1 more source