Results 41 to 50 of about 1,046,320 (355)

Therapeutic Drug Monitoring of Ganciclovir: Where Are We?

Therapeutic Drug Monitoring, 2021
Background: Ganciclovir is the mainstay of therapy for the prophylaxis and treatment of Cytomegalovirus. However, therapy with this antiviral agent is hindered by side effects such as myelosuppression, which often leads to therapy cessation. Underdosing,
A. Märtson, A. E. Edwina, H. Kim, M. Knoester, D. Touw, M. Sturkenboom, J. Alffenaar   +6 more
semanticscholar   +1 more source

Explainable Artificial Intelligence for Pharmacovigilance: What Features Are Important When Predicting Adverse Outcomes? [PDF]

, 2021
Explainable Artificial Intelligence (XAI) has been identified as a viable method for determining the importance of features when making predictions using Machine Learning (ML) models. In this study, we created models that take an individual's health information (e.g.
arxiv   +1 more source

Phenoconversion and therapeutic drug monitoring [PDF]

British Journal of Clinical Pharmacology, 2015
Keywords: clobazam; clozapine; genotype–phenotype mismatch; personalized medicine; pharmacogenetics; risperidone; therapeutic drug monitoring ...
Jose de Leon, Jose de Leon, Jose de Leon
openaire   +3 more sources

Pharmacologic Treatment of Transplant Recipients Infected With SARS-CoV-2: Considerations Regarding Therapeutic Drug Monitoring and Drug–Drug Interactions

Therapeutic Drug Monitoring, 2020
Background: COVID-19 is a novel infectious disease caused by the severe acute respiratory distress (SARS)-coronavirus-2 (SARS-CoV-2). Several therapeutic options are currently emerging but none with universal consensus or proven efficacy.
L. Elens, L. Langman, D. Hesselink, S. Bergan, D. Moes, M. Molinaro, R. Venkataramanan, F. Lemaitre   +7 more
semanticscholar   +1 more source

Meropenem use and therapeutic drug monitoring in clinical practice: a literature review

Journal of Clinical Pharmacy and Therapeutics, 2021
Meropenem, a carbapenem antibiotic, is widely prescribed for the treatment of life‐threatening infections. The main parameter associated with its therapeutic success is the percentage of time that the levels remain above the minimum inhibitory ...
N. A. Steffens, E. Zimmermann, S. M. Nichelle, Natália Brucker   +3 more
semanticscholar   +1 more source

Ganciclovir therapeutic drug monitoring in transplant recipients

Journal of Antimicrobial Chemotherapy, 2021
Background The use of (val)ganciclovir is complicated by toxicity, slow response to treatment and acquired resistance. Objectives To evaluate a routine therapeutic drug monitoring (TDM) programme for ganciclovir in a transplant patient population ...
A. Märtson, A. E. Edwina, J. Burgerhof, S. Berger, A. D. de Joode, K. Damman, E. Verschuuren, H. Blokzijl, Martijn Bakker, L. Span, T. S. van der Werf, D. Touw, M. Sturkenboom, M. Knoester, J. C. Alffenaar   +14 more
semanticscholar   +1 more source

Monitoring of sedation depth in intensive care unit by therapeutic drug monitoring? A prospective observation study of medical intensive care patients

Journal of Intensive Care, 2018
Background Analgosedation is a cornerstone therapy for mechanically ventilated patients in intensive care units (ICU). To avoid inadequate sedation and its complications, monitoring of analgosedation is of great importance.
Richard J. Nies, Carsten Müller, Roman Pfister, Philipp S. Binder, Nicole Nosseir, Felix S. Nettersheim, Kathrin Kuhr, Martin H. J. Wiesen, Matthias Kochanek, Guido Michels   +9 more
doaj   +1 more source

Therapeutic Drug Monitoring of Antibiotics Is Needed in the Treatment of Sepsis

Вестник анестезиологии и реаниматологии, 2022
The article presents the results of a prospective one-center observational clinical study.The level of therapeutic drug monitoring antibiotics was studied in patients with sepsis.The objective: to assess the impact of pharmacokinetics and ...
G. P. Plotnikov, A. N. Kudryavtsev, A. A. Kleuzovich, A. G. Chizhov, A. A. Ponomarev, S. S. Larin, E. A. Litvin, L. A. Anastasevich   +7 more
doaj   +1 more source

Therapeutic drug monitoring of oral targeted antineoplastic drugs

European Journal of Clinical Pharmacology, 2020
This review provides an overview of the current challenges in oral targeted antineoplastic drug (OAD) dosing and outlines the unexploited value of therapeutic drug monitoring (TDM).
Anna Mueller‐Schoell, S. Groenland, Oliver Scherf-Clavel, M. van Dyk, W. Huisinga, R. Michelet, U. Jaehde, N. Steeghs, A. Huitema, C. Kloft   +9 more
semanticscholar   +1 more source

Scalable Graphene Aptasensors for Drug Quantification [PDF]

AIP Advances 7, 115111 (2017), 2017
Simpler and more rapid approaches for therapeutic drug-level monitoring are highly desirable to enable use at the point-of-care. We have developed an all-electronic approach for detection of the HIV drug tenofovir based on scalable fabrication of arrays of graphene field-effect transistors (GFETs) functionalized with a commercially available DNA ...
arxiv   +1 more source