Results 31 to 40 of about 1,123,683 (262)
Metformin: A Potential Therapeutic Tool for Rheumatologists [PDF]
Pharmaceuticals, 2020 Metformin is an oral antihyperglycemic drug widely used to treat type 2 diabetes, acting via indirect activation of 5′ Adenosine Monophosphate-activated Protein Kinase (AMPK). Actually, evidence has accumulated of an intriguing anti-inflammatory activity, mainly mediated by AMPK through a variety of mechanisms such as the inhibition of cytokine ...
Teresa Salvatore +10 more
openaire +4 more sources
Clinical proteomics for precision medicine: the bladder cancer case [PDF]
, 2017 Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics based approaches.
Frantzi, Maria +4 more
core +1 more source
The therapeutic use of videogames within secure forensic settings: a review of the literature and application to practice [PDF]
, 2004 Engagement in leisure pursuits that involves the use of tools and objects and the exploration of a new environment can provide a success experience that leads to increased feelings of competence and mastery.
Gooch, P., Living, R.
core +1 more source
Fluorescence-based proteasome activity profiling [PDF]
, 2012 With the proteasome emerging as a therapeutic target for cancer treatment, accurate tools for monitoring proteasome (inhibitor) activity are in demand.
Berkers, C.R. +4 more
core +1 more source
Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core +1 more source
Alzheimer’s Research & Therapy, 2023 Background Therapeutic trials in Alzheimer’s disease (AD) face many obstacles—particularly with regard to screening and recruitment. Discussion Decentralized clinical trials (DCTs) are being developed in other diseases and appear to be of value for ...
Victoire Leroy +8 more
doaj +1 more source
Elucidating Berberine’s Therapeutic and Photosensitizer Potential through Nanomedicine Tools
Pharmaceutics, 2023 Berberine, an isoquinoline alkaloid extracted from plants of the Berberidaceae family, has been gaining interest due to anti-inflammatory and antioxidant activities, as well as neuro and cardiovascular protective effects in animal models.
Célia Marques +2 more
doaj +1 more source
Recent advances in managing differentiated thyroid cancer [PDF]
, 2018 The main clinical challenge in the management of thyroid cancer is to avoid over-treatment and over-diagnosis in patients with lower-risk disease while promptly identifying those patients with more advanced or high-risk disease requiring aggressive ...
Durante, Cosimo +3 more
core +2 more sources
PharmaceuticalsDespite decades of rigorous research and numerous clinical trials, Alzheimer’s disease (AD) stands as a notable healthcare challenge of this century, with effective therapeutic solutions remaining elusive.
Gabriela Dumitrita Stanciu +7 more
doaj +1 more source
Extracellular vesicles as therapeutic tools in cardiovascular diseases
Frontiers in Immunology, 2014 Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, are small vesicles secreted from a wide variety of cells. Whereas MVs are particles released by the outward budding of the plasma membrane, exosomes are derived from endocytic ...
Audrey eFleury +2 more
doaj +1 more source