Results 171 to 180 of about 1,970,330 (303)

A randomized trial of viral vector and adjuvanted protein HBV therapeutic vaccine in people with chronic hepatitis B on nucleos(t)ide analogs. [PDF]

Hepatol Commun
Jeng WJ, Chu CJ, Leerapun A, Avihingsanon A, Zeuzem S, Bourgeois S, Yuen MF, Romero-Gomez M, Yang SS, Cravcenco C, Salaun B, Shi M, Vassilev V, Kim JH, Swinnen K, and the TH HBV VV-001 Study Group.   +15 more
europepmc   +1 more source

Conserved multiepitope vaccine constructs: A potent HIV-1 therapeutic vaccine in clinical trials. [PDF]

Braz J Infect Dis, 2023
Akbari E, Seyedinkhorasani M, Bolhassani A.   +2 more
europepmc   +1 more source

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

Systems Vaccinology-Integrated Proteomics to Develop a Novel Prophylactic and Therapeutic Vaccine Against Human Papillomavirus 16. [PDF]

Bioinform Biol Insights
Fathi S, Solhjoo A, Bagheri A, Sakhteman A, Ghasemi Y, Negahdaripour M.   +5 more
europepmc   +1 more source

A Therapeutic Vaccine Targeting Rat BORIS (CTCFL) for the Treatment of Rat Breast Cancer Tumors. [PDF]

Int J Mol Sci, 2023
Loukinov D, Anderson AL, Mkrtichyan M, Ghochikyan A, Rivero-Hinojosa S, Tucker J, Lobanenkov V, Agadjanyan MG, Nelson EL.   +8 more
europepmc   +1 more source

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

Advanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma, Changyuan Kang, Xixian Liu, Lichao Yang, Mengyi Li, Yuting Ye, Jianfang Zhang, Yingjun Li, Guanghui Jin, Yang Liu, Xiaohong Chen, Kexin Wang, Zifeng Yang   +12 more
wiley   +1 more source

A novel mRNA-based therapeutic vaccine elicits robust anti-tumor immunity against HPV-associated malignancies. [PDF]

Front Immunol
Li Q, Liu Y, Wang Y, Li Z.
europepmc   +1 more source

Nanoliposomal VEGF-R2 peptide vaccine acts as an effective therapeutic vaccine in a murine B16F10 model of melanoma. [PDF]

Cancer Nanotechnol, 2023
Zahedipour F, Zamani P, Mashreghi M, Astaneh M, Sankian M, Amiri A, Jamialahmadi K, Jaafari MR.   +7 more
europepmc   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Circular RNA-based HPV16 therapeutic vaccine elicits potent and durable antitumor immunity. [PDF]

J Exp Clin Cancer Res
Zhou R, Li C, Xiang K, Cui L, Rong Y, Li L, Zhu M, Zeng J, Gao L.   +8 more
europepmc   +1 more source