Results 191 to 200 of about 1,970,330 (303)

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Erratum: Bio-nanoparticle based therapeutic vaccine induces immunogenic response against triple negative breast cancer. [PDF]

Am J Cancer Res
Bai X, Zhou Y, Lin Q, Huang CK, Zhang S, Carlson RI, Ghanbari H, Sun B, Wands JR, Dong X.   +9 more
europepmc   +1 more source

Optimizing Cancer Vaccinations Using a Physiologically‐Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model

Advanced Science, EarlyView.
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi, Timothy P. Padera, Lance L. Munn   +2 more
wiley   +1 more source

Correction: HPV16-Expressing Tumors Release Multiple IL1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic Vaccine. [PDF]

Cancer Discov
Lecointre M, Guillot J, Marcone R, Ozdoganlar D, Cayatte M, Gyllenbäck EJ, Liberg D, Fournier N, Homicsko K, Hanahan D.   +9 more
europepmc   +1 more source

Immunosuppressive biomaterial-based therapeutic vaccine to treat multiple sclerosis via re-establishing immune tolerance. [PDF]

Nat Commun, 2022
Nguyen TL, Choi Y, Im J, Shin H, Phan NM, Kim MK, Choi SW, Kim J.   +7 more
europepmc   +1 more source

Therapeutic Vaccination for Cancer

Clinical Immunology, 2000
openaire   +2 more sources

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

A CpG 1018S/QS-21-Adjuvanted HBsAg Therapeutic Vaccine as a Novel Strategy Against HBV. [PDF]

Vaccines (Basel)
Wang Z, Wu J, Meng X, Weng H, Li Q, Li L, Ma Z, Bi S, Han Q, Zhao H, Liu C, Meng D.   +11 more
europepmc   +1 more source

Investigation of the Optimal Prime Boost Spacing Regimen for a Cancer Therapeutic Vaccine Targeting Human Papillomavirus. [PDF]

Cancers (Basel), 2022
Da Silva DM, Martinez EA, Bogaert L, Kast WM.   +3 more
europepmc   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source