Results 211 to 220 of about 1,970,330 (303)

Risk management externalities in agrifood supply chains

American Journal of Agricultural Economics, EarlyView.
Abstract Firms may under‐ or over‐invest in risk management from the social planner's perspective, resulting in a negative externality on other economic agents in the supply chain. The externality of risk management is particularly relevant for agrifood supply chains, which frequently experience disruptions and play a primary role in preventing major ...
Jeffrey Hadachek, Meilin Ma
wiley   +1 more source

Characterization of a novel <i>Leishmania</i> antigen containing a repetitive domain and its potential use as a prophylactic and therapeutic vaccine. [PDF]

mSphere
de Oliveira B, Goes WM, Nascimento FC, Carnielli JBT, Ferreira ER, de Carvalho AF, Dos Reis PVM, Pereira M, Ricotta TQN, Dos Santos LM, de Souza RP, Cargnelutti DE, Mottram JC, Teixeira SR, Fernandes AP, Gazzinelli RT.   +15 more
europepmc   +1 more source

Characteristics Associated With Persistent Long COVID Symptoms in Healthcare Personnel Infected With SARS‐CoV‐2 Between August 2022 and May 2024: A Multicenter Cohort Analysis of US Healthcare Personnel

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Long COVID affects a significant proportion of COVID‐19 survivors. This study examined persistent Long COVID symptoms among healthcare personnel (HCP) and evaluated associations with vaccination, prior SARS‐CoV‐2 infection, underlying health conditions, and demographics.
Eric Kontowicz, Amanda K. Irish, Lilly C. Lee, Howard A. Smithline, Ian D. Plumb, Melissa Briggs‐Hagen, Alexandra F. Rollins, Karisa K. Harland, Anusha Krishnadasan, Karin F. Hoth, Eliezer Santos‐León, David A. Talan, Nicholas M. Mohr, Project PREVENT Network   +13 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

HPV16-Expressing Tumors Release Multiple IL1 Ligands to Orchestrate Systemic Immunosuppression Whose Disruption Enables Efficacy of a Therapeutic Vaccine. [PDF]

Cancer Discov
Lecointre M, Guillot J, Marcone R, Ozdoganlar D, Cayatte M, Jaensson Gyllenbäck E, Liberg D, Fournier N, Homicsko K, Hanahan D.   +9 more
europepmc   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins

Angewandte Chemie, EarlyView.
Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng, Tyson D. Todd, Alexandria L. Quillin, Harshad Ingle, Angela M. Halstead, Megan T. Baldridge, José B. Sáenz, Jennifer M. Heemstra   +7 more
wiley   +2 more sources

Multiplexed RNAs in lipid nanoparticles: potential therapeutic vaccine for chronic hepatitis B. [PDF]

Signal Transduct Target Ther
Rachamala HK, Marepally S.
europepmc   +1 more source

A rhesus macaque model of α‐dystroglycanopathy caused by a POMT1 splice altering variant

Animal Models and Experimental Medicine, EarlyView.
Rhesus macaques homozygous for a naturally occurring spice altering variant in the POMT1 gene develop lissencephaly, microphthalmia, and muscular contracture. The presentation models severe presentation of the human Walker‐Warburg syndrome. Abstract Background Biallelic mutations in genes associated with α‐dystroglycan glycosylation manifest in a ...
Anya Nordlund, Brian LaMendola, Nathan P. Crilly, Seth Kittle, Betsy M. Ferguson, Anne D. Lewis, Jeff Wall, Samuel M. Peterson   +7 more
wiley   +1 more source

HLA I immunopeptidome of synthetic long peptide pulsed human dendritic cells for therapeutic vaccine design. [PDF]

NPJ Vaccines
Kessler AL, Pieterman RFA, Doff WAS, Bezstarosti K, Bouzid R, Klarenaar K, Jansen DTSL, Luijten RJ, Demmers JAA, Buschow SI.   +9 more
europepmc   +1 more source