Results 11 to 20 of about 3,300,951 (351)

Hepatitis B Therapeutic Vaccine: A Patent Review. [PDF]

Pharmaceuticals (Basel), 2022
Viral hepatitis has long been underrated as a danger to global health. The UN only recently called for worldwide action to tackle viral hepatitis and lessen the disease burden in its “2030 Agenda for Sustainable Development”.
Hudu SA, Jimoh AO, Ibrahim KG, Alshrari AS.   +3 more
europepmc   +2 more sources

Immunosuppressive biomaterial-based therapeutic vaccine to treat multiple sclerosis via re-establishing immune tolerance. [PDF]

Nat Commun, 2022
Current therapies for autoimmune diseases, such as multiple sclerosis (MS), induce broad suppression of the immune system, potentially promoting opportunistic infections. Here, we report an immunosuppressive biomaterial-based therapeutic vaccine carrying
Nguyen TL, Choi Y, Im J, Shin H, Phan NM, Kim MK, Choi SW, Kim J.   +7 more
europepmc   +2 more sources

Immunogenicity and effectiveness of an mRNA therapeutic vaccine for HPV-related malignancies. [PDF]

Life Sci Alliance
mHTV-02 functions as a candidate effective therapeutic mRNA-LNP vaccine via intramuscular or intratumoral administration routes for treating malignancies caused by HPV16 or HPV18 infections. Human papillomavirus (HPV) infections account for several human
Wang J, Ma L, Chen Y, Zhou R, Wang Q, Zhang T, Yi D, Liu Q, Zhang Y, Zhang W, Dong Y, Cen S.   +11 more
europepmc   +2 more sources

Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine. [PDF]

Adv Sci (Weinh), 2021
Success in anticancer immune therapy relies on stimulation of tumor antigen‐specific T lymphocytes and effective infiltration of the T cells into tumor tissue.
Mai J, Li Z, Xia X, Zhang J, Li J, Liu H, Shen J, Ramirez M, Li F, Li Z, Yokoi K, Liu X, Mittendorf EA, Ferrari M, Shen H.   +14 more
europepmc   +2 more sources

Harnessing RNA Technology to Advance Therapeutic Vaccine Antigens against Chagas Disease. [PDF]

ACS Appl Mater Interfaces
Chagas disease (CD) (American trypanosomiasis caused by Trypanosoma cruzi) is a parasitic disease endemic in 21 countries in South America, with increasing global spread.
Mancino C, Pollet J, Zinger A, Jones KM, Villar MJ, Leao AC, Adhikari R, Versteeg L, Tyagi Kundu R, Strych U, Giordano F, Hotez PJ, Bottazzi ME, Taraballi F, Poveda C.   +14 more
europepmc   +2 more sources

Intranasal therapeutic vaccine containing HBsAg and HBcAg for patients with chronic hepatitis B; 18 months follow‐up results of phase IIa clinical study

Hepatology Research, 2022
HBsAg loss with anti‐HBs acquisition is considered a functional cure and ideal treatment goal for patients with CHB. Our group have reported the efficacy of therapeutic vaccine with HBsAg and HBcAg (NASVAC) by intranasal and subcutaneous injection.
O. Yoshida, S. M. Akbar, Yusuke Imai, Takahiro Sanada, K. Tsukiyama-Kohara, T. Miyazaki, Taizou Kamishita, T. Miyake, Yoshio Tokumoto, Hayato Hikita, M. Tsuge, M. Shimizu, Mamun Al Mahtab, J. Aguilar, G. Guillén, M. Kohara, Y. Hiasa   +16 more
semanticscholar   +1 more source

Safety and efficacy of prophylactic and therapeutic vaccine based on live-attenuated Listeria monocytogenes in hepatobiliary cancers

Oncogene, 2022
Primary liver cancer (PLC) comprising hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) represents the third deadliest cancer worldwide with still insufficient treatment options.
I. Hochnadel, L. Hoenicke, N. Petriv, Lavinia Neubert, Elena Reinhard, Tatjana Hirsch, J. Alfonso, H. Suo, T. Longerich, R. Geffers, R. Lichtinghagen, C. Guzmán, H. Wedemeyer, H. Lenzen, M. Manns, D. Bruder, T. Yevsa   +16 more
semanticscholar   +1 more source

NK cells limit therapeutic vaccine–induced CD8+T cell immunity in a PD-L1–dependent manner

Science Translational Medicine, 2022
A better understanding of mechanisms that regulate CD8+T cell responses to therapeutic vaccines is needed to develop approaches to enhance vaccine efficacy for chronic viral infections and cancers.
M. Diniz, Anna Schurich, Senthil Chinnakannan, M. Duriez, K. Stegmann, J. Davies, Stephanie Kucykowicz, K. Suveizdytė, O. E. Amin, Frances Alcock, T. Cargill, E. Barnes, M. Maini   +12 more
semanticscholar   +1 more source

Unsaturated, Trialkyl Ionizable Lipids are Versatile Lipid‐Nanoparticle Components for Therapeutic and Vaccine Applications

Advances in Materials, 2023
Lipid nanoparticles (LNPs) have proven a successful platform for the delivery of nucleic acid (NA)‐based therapeutics and vaccines, with the ionizable lipid component playing a key role in modulating potency and tolerability.
Kieu Lam, A. Leung, Alan D. Martin, M. Wood, Petra Schreiner, L. Palmer, Owen H. Daly, Wenchen Zhao, K. Mcclintock, J. Heyes   +9 more
semanticscholar   +1 more source

Harnessing the Potential of Plant Expression System towards the Production of Vaccines for the Prevention of Human Papillomavirus and Cervical Cancer

Vaccines, 2022
Cervical cancer is the most common gynecological malignant tumor worldwide, and it remains a major health problem among women, especially in developing countries.
Balamurugan Shanmugaraj, Ashwini Malla, Christine Joy I. Bulaon, Waranyoo Phoolcharoen, Natacha Phoolcharoen   +4 more
doaj   +1 more source