Results 41 to 50 of about 3,300,951 (351)

Therapeutic HPV DNA vaccines [PDF]

Immunologic Research, 2010
It is now well established that most cervical cancers are causally associated with HPV infection. This realization has led to efforts to control HPV-associated malignancy through prevention or treatment of HPV infection. Currently, commercially available HPV vaccines are not designed to control established HPV infection and associated premalignant and ...
Ken, Lin, Elena, Roosinovich, Barbara, Ma, Chien-Fu, Hung, T-C, Wu   +4 more
openaire   +2 more sources

SARS-CoV-2 BA.1 variant is neutralized by vaccine booster-elicited serum, but evades most convalescent serum and therapeutic antibodies

Science Translational Medicine, 2022
The rapid spread of the highly contagious Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) along with its high number of mutations in the spike gene has raised alarms about the effectiveness of current medical ...
Sabrina Lusvarghi, S. Pollett, S. Neerukonda, Wei Wang, Richard Wang, R. Vassell, N. Epsi, A. Fries, B. Agan, D. Lindholm, C. Colombo, R. Mody, E. Ewers, T. Lalani, A. Ganesan, E. Goguet, M. Hollis-Perry, S. Coggins, M. Simons, L. Katzelnick, Gregory Wang, D. Tribble, Lisa Bentley, A. Eakin, C. Broder, Karl J. Erlandson, E. Laing, T. Burgess, E. Mitre, C. Weiss   +29 more
semanticscholar   +1 more source

Development of a Human Cytomegalovirus (HCMV)-Based Therapeutic Cancer Vaccine Uncovers a Previously Unsuspected Viral Block of MHC Class I Antigen Presentation [PDF]

, 2019
Human cytomegalovirus (HCMV) induces a uniquely high frequency of virus-specific effector/memory CD8+ T-cells, a phenomenon termed “memory inflation”.
Abate, Ahmed, Alexandrov, Alexandrov, Arnon, Avdic, Beyranvand Nejad, Brown, Brown, Browne, Chang, Chu, Cloughesy, Cobbs, Dasari, Dekhtiarenko, Del Val, Desjardins, Doisne, Dos Santos, Draper, Duhen, Dziurzynski, Engels, Fiallos, Filley, Fruh, Galluzzi, Gilbert, Gorzer, Harkins, Heemskerk, Howland, Jarry, Johnson, Jutz, Jutz, Kern, Klenerman, Korn, Kotenko, Lauvau, Le, Leisegang, Lim, Lockridge, Locy, Louveau, Lucas, Luo, Malouli, Martikainen, Mitchell, Mocarski, Nair, Neefjes, Odeberg, Overwijk, Pardieck, Polyzoidis, Potter, Prins, Pule, Raftery, Raftery, Raftery, Raftery, Rahman, Ratzinger, Reap, Reardon, Reed, Ressing, Riegler, Rizvi, Rosato, Rosskopf, Sampaio, Sampson, Sandalova, Schempp, Scheper, Schmolke, Schneider, Schonrich, Schub, Sckisel, Shah, Simoni, Sinzger, Soroceanu, Soroceanu, Strang, Stupp, Sturm, Sugawara, Sylwester, Thomas, Tischer, Tran, Trgovcich, Tumeh, van der Burg, van Willigen, Varnum, Vlahovic, Wen, Wills, Yan, Zhao   +109 more
core   +1 more source

Unintended HIV-1 Transmission to a Sex Partner in a Study of a Therapeutic Vaccine Candidate.

Journal of Infectious Diseases, 2019
We report a case of sexual transmission of human immunodeficiency virus (HIV) that occurred during treatment discontinuation in a therapeutic vaccine trial, following oral sex.
J. Lelièvre, L. Hocqueloux
semanticscholar   +1 more source

mRNA vaccine: a potential therapeutic strategy

Molecular Cancer, 2021
mRNA vaccines have tremendous potential to fight against cancer and viral diseases due to superiorities in safety, efficacy and industrial production.
Yang Wang, Ziqi Zhang, Jingwen Luo, Xuejiao Han, Yuquan Wei, Xiawei Wei   +5 more
semanticscholar   +1 more source

Immunotherapy of lung cancer: An update [PDF]

, 2006
In Germany lung cancer is the leading cause of cancer-associated death in men. Surgery, chemotherapy and radiation may enhance survival of patients suffering from lung cancer but the enhancement is typically transient and mostly absent with advanced ...
Aman MJ, Anthony HM, Atanackovic D, Bast RC, Bermers AJA, Carbone FR, Chan B, Cohen MH, Dickler M, Dranoff G, Dudley ME, Faradji A, Gotoh K, Grant SC, Kimura H, Kimura Y, Korkolopoulou P, Kradin RL, Krug LM, Krug LM, Liu M, Ma J, Marshall JL, Melioli G, Millar JW, Nemunaitis J, Nikitina E, O'Brien ME, Palmer M, Raez LE, Ratto GB, Salgia R, Smith A, Sterman D, Swisher S, Villalona-Calero MA, Yano T   +36 more
core   +1 more source

Patient-specific dendritic cell vaccines with autologous tumor antigens in 72 patients with metastatic melanoma

Melanoma Management, 2019
Aim: Metastatic melanoma patients were treated with patient-specific vaccines consisting of autologous dendritic cells loaded with antigens from irradiated cells from short-term autologous tumor cell lines. Patients & methods: A total of 72 patients were
Robert O Dillman, Andrew N Cornforth, Edward F McClay, Carol Depriest   +3 more
doaj   +1 more source

Potent Therapeutic Efficacy of a Novel HPV16E7-HBcAg-Hsp65 Fusion Protein Vaccine

Vaccine Research, 2021
Introduction: Cervical cancer is the fourth leading cause of cancer death in women worldwide. Nearly all cervical cancers are resulted from high-risk Human Papillomavirus (HPV) infection. Currently, there is no available HPV-specific therapy.
Chao Zhang, Chenliang Zhou, Xiaoliang Wang, Xinxing Ma, Meijun Diao, Haitao Liu, Dan Xu, Jian Wei, Yuanxiang Jiang, Menghua Zhang, Lingyun Zhou, Jiang Fan, Ge Liu   +12 more
doaj   +1 more source

HBV X protein-based therapeutic vaccine accelerates viral antigen clearance by mobilizing monocyte infiltration into the liver in HBV carrier mice

Journal of Biomedical Sciences, 2020
Hepatitis B virus (HBV) persistently infected about 250 million people worldwide, and a curative treatment remains an unmet medical need. Among many approaches to treat chronic hepatitis B (CHB), therapeutic vaccines have been developed for two decades ...
Jau-Hau Horng, Wei-Hsiang Lin, Chang-Ru Wu, You-Yu Lin, Li-Ling Wu, Ding‐Shinn Chen, Pei‐Jer Chen   +6 more
semanticscholar   +1 more source

A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection

PLoS Neglected Tropical Diseases, 2019
Chagas disease, caused by the parasite Trypanosoma cruzi, develops into chronic Chagas’ cardiomyopathy in ~30% of infected individuals, characterized by conduction disorders, arrhythmias, heart failure, and even sudden cardiac death.
Meagan A Barry, Leroy Versteeg, Qian Wang, J. Pollet, B. Zhan, F. Gusovsky, M. Bottazzi, P. Hotez, Kathryn M. Jones   +8 more
semanticscholar   +1 more source