Results 111 to 120 of about 1,429,081 (399)

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic [PDF]

, 2015
Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the ...
Boyle, Ross, Bryden, Francesca, Caddick, Stephen, Chudasama, Vijay, Maruani, Antoine, Savoie, Huguette   +5 more
core   +2 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Application of Radiosensitizers in Cancer Radiotherapy [Corrigendum]

International Journal of Nanomedicine, 2021
Gong L, Zhang Y, Liu C, Zhang M, Han S. Int J Nanomedicine. 2021;16:1083–1102. The authors have advised there is an error with the reference list on page 1100. Reference 160 should read as follows. 160.
Gong L, Zhang Y, Liu C, Zhang M, Han S
doaj  

Protein-ligand interaction study to identify potential dietary compounds binding at the active site of therapeutic target proteins of SARS-CoV-2 [PDF]

arXiv, 2020
Objective: Total 186 biologically important phenylpropanoids and polyketides compounds from different Indian medicinal plants and dietary sources were screened to filter potential compounds that bind at the active site of the therapeutic target proteins of SARS-CoV-2.
arxiv  

Partitioning of cancer therapeutics in nuclear condensates

Science, 2020
Drug partitioning in nuclear condensates There is increasing interest in the function of phase-separated biomolecular condensates in cells because of their distinct properties and expanding roles in important biological processes. Klein et al. considered
Isaac A. Klein, Ann Boija, Lena K. Afeyan, S. W. Hawken, Mengyang Fan, Alessandra Dall’Agnese, Ozgur Oksuz, J. Henninger, Krishna Shrinivas, Benjamin R. Sabari, I. Sagi, Victoria E. Clark, Jesse M. Platt, Mrityunjoy Kar, Patrick M. McCall, A. V. Zamudio, John C. Manteiga, Eliot L. Coffey, Charles H. Li, N. Hannett, Y. Guo, T. Decker, Tong Ihn Lee, Tinghu Zhang, J. Weng, D. Taatjes, A. Chakraborty, P. Sharp, Young‐Tae Chang, A. Hyman, N. Gray, R. Young   +31 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Structure of anellovirus-like particles reveal a mechanism for immune evasion

Nature Communications
Anelloviruses are nonpathogenic viruses that comprise a major portion of the human virome. Despite being ubiquitous in the human population, anelloviruses (ANVs) remain poorly understood.
Shu-hao Liou, Rajendra Boggavarapu, Noah R. Cohen, Yue Zhang, Ishwari Sharma, Lynn Zeheb, Nidhi Mukund Acharekar, Hillary D. Rodgers, Saadman Islam, Jared Pitts, Cesar Arze, Harish Swaminathan, Nathan Yozwiak, Tuyen Ong, Roger J. Hajjar, Yong Chang, Kurt A. Swanson, Simon Delagrave   +17 more
doaj   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells

Communications Biology
Adoptive cell therapies (ACT) have shown reduced efficacy against solid tumor malignancies compared to hematologic malignancies, partly due to the immunosuppressive nature of the tumor microenvironment (TME). ACT efficacy may be enhanced with pleiotropic
Mara C. Inniss, Sean G. Smith, Dan Jun Li, Benjamin Primack, Dexue Sun, Grace Y. Olinger, Kerri-Lynn Sheahan, Theresa Ross, Meghan Langley, Violet Young, Andres Alvarado, Shabnam Davoodi, Jiefei Geng, Michael Schebesta, Michelle L. Ols, Jeremy Tchaicha, Jan ter Meulen, Dhruv K. Sethi   +17 more
doaj   +1 more source

Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention

Frontiers in Pharmacology, 2020
With the objective of linking early findings relating to the novel SARS-CoV-2 coronavirus with potentially informative findings from prior research literature and to promote investigation toward therapeutic response, a coherent cellular and molecular ...
John P. Hussman
doaj   +1 more source