Results 111 to 120 of about 1,412,582 (334)

Multifunctional GelMA platforms with nanomaterials for advanced tissue therapeutics

, 2021
Amal George Kurian, Rajendra K. Singh, Kapil D. Patel, Jung‐Hwan Lee, Hae‐Won Kim   +4 more
openalex   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Integrated transcriptomic and functional modeling reveals AKT and mTOR synergy in colorectal cancer

Scientific Reports
Colorectal cancer (CRC) treatment remains challenging due to genetic heterogeneity and resistance mechanisms. To address this, we developed a drug discovery pipeline using patient-derived primary CRC cultures with diverse genomic profiles. These cultures
Marcin Duleba, Eliza Zimoląg, Joanna Szuszkiewicz, Marcin Serocki, Joanna Szklarczyk, Olga Dracz, Alexander Kurzejamski, Izabella Więckowska, Marcelina Chmiel, Barbara Lipert, Katarzyna Sarad, Joanna Krawczyk, Oleksii Bryzghalov, Agata Stachowicz-Wałaszek, Karolina Pyziak, Joanna Drozdowska, Krzysztof Baczyński, Konrad Wojtowicz, Maurycy Chronowski, Krzysztof Rataj, Magdalena Otrocka, Michał Mikula, Paula Feliksiak, Rafał Dziadziuszko, Tomasz Rzymski, Andrew Thomason, Krzysztof Brzózka, Andrzej Mazan   +27 more
doaj   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics

, 2023
Pengzhi Shi, Zhangrong Cheng, Kangcheng Zhao, Yuhang Chen, Anran Zhang, Weikang Gan, Yukun Zhang   +6 more
openalex   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Cell-penetrating peptides in protein mimicry and cancer therapeutics

, 2021
Matjaž Zorko, Sarah Jones, Ülo Langel
openalex   +1 more source

Bioadhesive Tannic-Acid-Functionalized Zein Coating Achieves Engineered Colonic Delivery of IBD Therapeutics via Reservoir Microdevices [PDF]

, 2022
Khorshid Kamguyan, Rolf Bech Kjeldsen, Saeed Zajforoushan Moghaddam, Melanie Randahl Nielsen, Esben Thormann, Kinga Zór, Line Hagner Nielsen, Anja Boisen   +7 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

REVIEW OF MUSIC AND ITS THERAPEUTICS W.S.R. AYURVEDIC CLASSICS (BRIHATRAYEE [PDF]

, 2016
Ayurveda is the science of living being. With the aim of health and procurement of disease it almost covers all facets of life. It includes health of an individual at physical, mental, spiritual, social level.
Upadhyay, Dr Devanand
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