Results 121 to 130 of about 1,429,081 (399)
Developing Predictive Molecular Maps of Human Disease through Community-based Modeling [PDF]
, 2011 The failure of biology to identify the molecular causes of disease has led to disappointment in the rate of development of new medicines. By combining the power of community-based modeling with broad access to large datasets on a platform that promotes ...
Christine Suver +10 more
core +2 more sources
Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies
Molecular Oncology, EarlyView.Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren +16 more
wiley +1 more source
Pharmacy & Therapeutics Update: Drug Information for Health Care Professionals [PDF]
, 2007 https://medica-musc.researchcommons.org/musc-ptupdate/1002/thumbnail ...
Bush, Paul +3 more
core +15 more sources
The Promising Viral Threat to Bacterial Resistance: The Uncertain Patentability of Phage Therapeutics and the Necessity of Alternative Incentives [PDF]
, 2014 Bacteriophages, or “phages,” are a category of highly adept and adaptable viruses that can infect and kill bacteria. With concerns over the burgeoning antibiotic-resistance crisis looming in recent years, scientists and policymakers have expressed a ...
Todd, Kelly
core +2 more sources
Predicting therapeutic and aggravating drugs for hepatocellular carcinoma based on tissue-specific pathways [PDF]
arXiv, 2017 Motivation: Hepatocellular carcinoma (HCC) is a significant health problem worldwide and annual number of cases are nearly more than 700,000. However,there are few safe and effective thera-peutic options for HCC patients.Here, we propose a new approach for predicting therapeutic and aggravating drugs for HCCbased ontissue-specificpathways, which ...
arxiv
Social and Emotional Skills Training with Embodied Moxie [PDF]
arXiv, 2020 We present a therapeutic framework, namely STAR Framework, that leverages established and evidence-based therapeutic strategies delivered by the Embodied Moxie, an animate companion to support children with mental behavioral developmental disorders (MBDDs).
arxiv
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
Nature CommunicationsNucleobase editors represent an emerging technology that enables precise single-base edits to the genomes of eukaryotic cells. Most nucleobase editors use deaminase domains that act upon single-stranded DNA and require RNA-guided proteins such as Cas9 to
Friedrich Fauser +18 more
doaj +1 more source
Photostimulated spin-flip and the photodynamic therapeutic effect of fullerene solutions [PDF]
arXiv, 2010 A new mechanism of photodynamic therapeutic effect of fullerene solution is suggested. Spin flip of electrons in oxygen molecule in the vicinity of negative-positive ion pair of fullerene lays the foundation of high oxidative activity of complexes C60(minus) -O2 and C60(plus)-O2.
arxiv