Results 41 to 50 of about 1,429,081 (399)
A Multi-Modal Contrastive Diffusion Model for Therapeutic Peptide Generation [PDF]
arXiv, 2023 Therapeutic peptides represent a unique class of pharmaceutical agents crucial for the treatment of human diseases. Recently, deep generative models have exhibited remarkable potential for generating therapeutic peptides, but they only utilize sequence or structure information alone, which hinders the performance in generation.
arxiv
A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics.
New England Journal of Medicine, 2019 BACKGROUND Although several experimental therapeutics for Ebola virus disease (EVD) have been developed, the safety and efficacy of the most promising therapies need to be assessed in the context of a randomized, controlled trial.
S. Mulangu +50 more
semanticscholar +1 more source
The Limitless Future of RNA Therapeutics
Frontiers in Bioengineering and Biotechnology, 2021 Recent advances in the generation, purification and cellular delivery of RNA have enabled development of RNA-based therapeutics for a broad array of applications.
T. Damase +5 more
semanticscholar +1 more source
Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase. [PDF]
, 2019 Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and ...
Cui, Xianshu +6 more
core +1 more source
Machine Learning Applications for Therapeutic Tasks with Genomics Data [PDF]
arXiv, 2021 Thanks to the increasing availability of genomics and other biomedical data, many machine learning approaches have been proposed for a wide range of therapeutic discovery and development tasks. In this survey, we review the literature on machine learning applications for genomics through the lens of therapeutic development. We investigate the interplay
arxiv
Adaptive immunity in cancer immunology and therapeutics. [PDF]
, 2014 Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution,
Lockley, M, Spurrell, EL
core +2 more sources
Phycological debriefing in acute traumatic events: Evidence synthesis
Medwave, 2022 Stressful life situations can generate chronic symptomatology, so it is of great concern to analyze preventive strategies. Psychological debriefing is an intervention for acute trauma, which verbalizes perceptions, thoughts, and emotions experienced ...
Marcelo Arancibia +6 more
doaj +1 more source
Big Data Transforms Discovery-Utilization Therapeutics Continuum. [PDF]
, 2016 Enabling omic technologies adopt a holistic view to produce unprecedented insights into the molecular underpinnings of health and disease, in part, by generating massive high-dimensional biological data.
Alfirevic +17 more
core +2 more sources
Some Perspectives on Network Modeling in Therapeutic Target Prediction [PDF]
Biomedical Engineering and Computational Biology, 5, 17-24, 2013, 2013 Drug target identification is of significant commercial interest to pharmaceutical companies, and there is a vast amount of research done related to the topic of therapeutic target identification. Interdisciplinary research in this area involves both the biological network community and the graph algorithms community. Key steps of a typical therapeutic
arxiv +1 more source