Results 41 to 50 of about 872,419 (247)

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis

Nature Communications
Synthetic lethality provides an attractive strategy for developing targeted cancer therapies. For example, cancer cells with high levels of microsatellite instability (MSI-H) are dependent on the Werner (WRN) helicase for survival.
Fernando Rodríguez Pérez, Dean Natwick, Lauren Schiff, David McSwiggen, Alec Heckert, Melina Huey, Huntly Morrison, Mandy Loo, Rafael G. Miranda, John Filbin, Jose Ortega, Kayla Van Buren, Danny Murnock, Arnold Tao, Renee Butler, Kylie Cheng, William Tarvestad, Zhengjian Zhang, Eric Gonzalez, Rand M. Miller, Marcus Kelly, Yangzhong Tang, Jaclyn Ho, Daniel Anderson, Charlene Bashore, Stephen Basham   +25 more
doaj   +1 more source

Therapeutic Strategies to Target Calcium Dysregulation in Alzheimer’s Disease

Cells, 2020
Alzheimer’s disease (AD) is the most common form of dementia, affecting millions of people worldwide. Unfortunately, none of the current treatments are effective at improving cognitive function in AD patients and, therefore, there is an urgent need for ...
Maria Calvo-Rodriguez, Elizabeth K. Kharitonova, Brian J. Bacskai   +2 more
doaj   +1 more source

RNAi-Based Therapy: Combating Shrimp Viral Diseases

Viruses, 2023
Shrimp aquaculture has become a vital industry, meeting the growing global demand for seafood. Shrimp viral diseases have posed significant challenges to the aquaculture industry, causing major economic losses worldwide.
Md. Shahanoor Alam, Mohammad Nazrul Islam, Mousumi Das, Sk. Farzana Islam, Md. Golam Rabbane, Ehsanul Karim, Animesh Roy, Mohammad Shafiqul Alam, Raju Ahmed, Abu Syed Md. Kibria   +9 more
doaj   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3’,5’-bisphosphate as a potent enzyme inhibitor

Communications Biology
XRN1 (5’-3’ exoribonuclease 1) degrades RNA from the 5′ → 3′ direction and utilizes both single- and double-stranded RNA as substrates. XRN1 plays a critical role in mRNA turnover as well as regulating the cellular response to viral infection.
Gordon J. Lockbaum, Maureen M. Lynes, Sophie A. Shen, Julie Liu, Nicholas Holt, Sunaina P. Nayak, Kevin E. Knockenhauer, Shihua Yao, E. Allen Sickmier, Anugraha Raman, Jie Wu, April Case, Livia Shehaj, Shane M. Buker, Simina Grigoriu, Scott Ribich, Stephen J. Blakemore, Brian A. Sparling, Kenneth W. Duncan, Robert A. Copeland, Serena J. Silver, P. Ann Boriack-Sjodin   +21 more
doaj   +1 more source

Extracellular Vesicles as Therapeutic and Diagnostic Tools for Chronic Liver Diseases

Biomedicines, 2023
Chronic liver diseases can lead to fibrotic changes that may progress to the development of cirrhosis, which poses a significant risk for morbidity and increased mortality rates.
Aleksandra Leszczynska, Christian Stoess, Hana Sung, Davide Povero, Akiko Eguchi, Ariel Feldstein   +5 more
doaj   +1 more source

Redox Buffering Capacity of Nanomaterials as an Index of ROS-based Therapeutics and Toxicity: A Preclinical Animal Study [PDF]

, 2021
Aniruddha Adhikari, Susmita Mondal, Monojit Das, Ria Ghosh, Pritam Biswas, Soumendra Darbar, Soumendra Singh, Anjan Kumar Das, Siddhartha Bhattacharya, Debasish Pal, Asim Kumar Mallick, Samir Kumar Pal   +11 more
openalex   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Emerging Alzheimer’s disease therapeutics: promising insights from lipid metabolism and microglia-focused interventions

Frontiers in Aging Neuroscience, 2023
More than 55 million people suffer from dementia, with this number projected to double every 20 years. In the United States, 1 in 3 aged individuals dies from Alzheimer’s disease (AD) or another type of dementia and AD kills more individuals than breast ...
Nour S. Tobeh, Nour S. Tobeh, Kimberley D. Bruce   +2 more
doaj   +1 more source