Results 41 to 50 of about 1,553,588 (375)
Scientific Reports, 2021 Variants in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with increased risk for familial and sporadic Parkinson’s disease (PD). Pathogenic variants in LRRK2, including the common variant G2019S, result in increased LRRK2 kinase activity,
Xiang Wang +14 more
doaj +1 more source
Pruritus in Keloid Scars: Mechanisms and Treatments
Acta Dermato-Venereologica, 2021 Keloids are scars that extend beyond the margins of an insulting cutaneous injury. Keloids are often thought to be primarily a cosmetic issue, as they are typically quite raised and pigmented. However, these scars also present with functional symptoms of
Ahmed A. Hawash +3 more
doaj +1 more source
Signaling pathways of chronic kidney diseases, implications for therapeutics
Signal Transduction and Targeted Therapy, 2022 Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) deposition.
Q. Yuan, B. Tang, Chun Zhang
semanticscholar +1 more source
The Emerging Roles and Therapeutic Potential of Extracellular Vesicles in Infertility
Frontiers in Endocrinology, 2021 Infertility is becoming much more common and affects more couples. The past years witnessed the rapid development of the diagnosis and treatment upon infertility, which give numerous coupled more opportunities become parents.
Guannan Zhou +14 more
doaj +1 more source
A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics.
New England Journal of Medicine, 2019 BACKGROUND Although several experimental therapeutics for Ebola virus disease (EVD) have been developed, the safety and efficacy of the most promising therapies need to be assessed in the context of a randomized, controlled trial.
S. Mulangu +50 more
semanticscholar +1 more source
The current landscape of nucleic acid therapeutics
Nature Nanotechnology, 2021 The increasing number of approved nucleic acid therapeutics demonstrates the potential to treat diseases by targeting their genetic blueprints in vivo.
J. Kulkarni +6 more
semanticscholar +1 more source
Role of nanoparticles in tackling COVID-19 pandemic: a bio-nanomedical approach
Journal of Taibah University for Science, 2021 COVID-19 Pandemic post threats to the life of millions of people across the globe as no specific therapeutics or vaccines have been scientifically proven.
Idris Zubairu Sadiq +2 more
doaj +1 more source
Frontiers in Immunology, 2021 The unprecedented 2015–2016 Zika outbreak in the Americas sparked global concern and drove the rapid deployment of vaccine and therapeutic countermeasures against this re-emerging pathogen.
Vincent Dussupt +6 more
doaj +1 more source