Results 71 to 80 of about 1,553,588 (375)

Best Practice Recommendations for Dysphagia Management in Stroke Patients: A Consensus from a Portuguese Expert Panel

Portuguese Journal of Public Health, 2022
Dysphagia is frequent after stroke, and it increases the risk of respiratory infection, dehydration and malnutrition, resulting in worse outcomes. Different clinical guidelines present recommendations for the assessment and management of dysphagia in ...
Isabel de Jesus Oliveira, Germano Rodrigues Couto, Rosa Vilares Santos, Ana Maria Campolargo, Cláudia Lima, Pedro Lopes Ferreira   +5 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Pancreatic cancer cachexia: a review of mechanisms and therapeutics. [PDF]

, 2014
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge.
Andrew Eugene Hendifar, Andrew Eugene Hendifar, Carlyn Rose Tan, Laith eJamil, Nick eNissen, Patrick eYaffee, Richard eTuli, Simon eLo, Stephen J Pandol   +8 more
core   +2 more sources

Drug Metabolism and Pharmacokinetics of Antisense Oligonucleotide Therapeutics: Typical Profiles, Evaluation Approaches, and Points to Consider Compared with Small Molecule Drugs

Nucleic Acid Therapeutics, 2023
Oligonucleotide therapeutics are attracting attention as a new treatment modality for a range of diseases that have been difficult to target using conventional approaches.
H. Takakusa, Norihiko Iwazaki, M. Nishikawa, Tokuyuki Yoshida, S. Obika, Takao Inoue   +5 more
semanticscholar   +1 more source

AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy

Communications Medicine
Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved treatments that address the underlying
Iris Wu, Aliya Zeng, Amara Greer-Short, J. Alex Aycinena, Anley E. Tefera, Reva Shenwai, Farshad Farshidfar, Melissa Van Pell, Emma Xu, Chris Reid, Neshel Rodriguez, Beatriz Lim, Tae Won Chung, Joseph Woods, Aquilla Scott, Samantha Jones, Cristina Dee-Hoskins, Carolina G. Gutierrez, Jessie Madariaga, Kevin Robinson, Yolanda Hatter, Renee Butler, Stephanie Steltzer, Jaclyn Ho, James R. Priest, Xiaomei Song, Frank Jing, Kristina Green, Kathryn N. Ivey, Timothy Hoey, Jin Yang, Zhihong Jane Yang   +31 more
doaj   +1 more source

Technological Approaches in the Analysis of Extracellular Vesicle Nucleotide Sequences

Frontiers in Bioengineering and Biotechnology, 2021
Together with metabolites, proteins, and lipid components, the EV cargo consists of DNA and RNA nucleotide sequence species, which are part of the intracellular communication network regulating specific cellular processes and provoking distinct target ...
Tine Tesovnik, Barbara Jenko Bizjan, Robert Šket, Maruša Debeljak, Tadej Battelino, Tadej Battelino, Jernej Kovač   +6 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Therapeutic mobilities [PDF]

Mobilities, 2019
This Special Issue expands mobilities research through the idea of therapeutic mobilities, which consist of multiple movements of health-related things and beings, including, though not limited to, nurses, doctors, patients, narratives, information, gifts and pharmaceuticals.
Heidi Kaspar, Margaret Walton-Roberts, Audrey Bochaton   +2 more
openaire   +3 more sources

Proteomics: in pursuit of effective traumatic brain injury therapeutics [PDF]

, 2015
Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived.
Ahmed F, Andrew K Ottens, Bales JW, Begum G, Berger RP, Bonislawski DP, Bos R, Boulenguez P, Boutte AM, Brandner S, Brandner S, Campos-Martorell M, Cortes DF, Crawford F, Dachir S, Daoud H, Evans TM, Gackiere F, Gonzalez MI, Guingab-Cagmat JD, Gyorgy A, Gyorgy AB, Jaramillo ML, Jeter CB, Kabadi SV, Kabadi SV, Kahle KT, Kumar A, Levi S, Li BC, Liang J, Liang J, Lin WM, Loane DJ, Loov C, Lopez NE, Maier O, Manley GT, Maurer MH, Mehan ND, Mohseni S, Mondello S, Mondello S, Ottens AK, Ottens AK, Pavel N Lizhnyak, Prieto DA, Rau TF, Rosenfeld JV, Saatman KE, Schmid KE, Shen S, Shen Y, Siman R, Siman R, Sun C, Talley Watts L, Tsai YT, Wagner AK, Wu P, Xiong Y, Yu W, Zetterberg H, Zgavc T, Zhou XM   +64 more
core   +2 more sources

Progress and challenges towards targeted delivery of cancer therapeutics

Nature Communications, 2018
Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past few decades. However, compared to the plethora of successful pre-clinical studies, only 15 passively targeted nanocarriers (NCs) have been approved for clinical ...
Daniel Rosenblum, N. Joshi, Wei Tao, J. Karp, D. Peer   +4 more
semanticscholar   +1 more source