Results 81 to 90 of about 797,768 (317)

Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells

Communications Biology
Adoptive cell therapies (ACT) have shown reduced efficacy against solid tumor malignancies compared to hematologic malignancies, partly due to the immunosuppressive nature of the tumor microenvironment (TME). ACT efficacy may be enhanced with pleiotropic
Mara C. Inniss, Sean G. Smith, Dan Jun Li, Benjamin Primack, Dexue Sun, Grace Y. Olinger, Kerri-Lynn Sheahan, Theresa Ross, Meghan Langley, Violet Young, Andres Alvarado, Shabnam Davoodi, Jiefei Geng, Michael Schebesta, Michelle L. Ols, Jeremy Tchaicha, Jan ter Meulen, Dhruv K. Sethi   +17 more
doaj   +1 more source

Predicting therapeutic and aggravating drugs for hepatocellular carcinoma based on tissue-specific pathways [PDF]

arXiv, 2017
Motivation: Hepatocellular carcinoma (HCC) is a significant health problem worldwide and annual number of cases are nearly more than 700,000. However,there are few safe and effective thera-peutic options for HCC patients.Here, we propose a new approach for predicting therapeutic and aggravating drugs for HCCbased ontissue-specificpathways, which ...
arxiv  

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Compact zinc finger architecture utilizing toxin-derived cytidine deaminases for highly efficient base editing in human cells

Nature Communications
Nucleobase editors represent an emerging technology that enables precise single-base edits to the genomes of eukaryotic cells. Most nucleobase editors use deaminase domains that act upon single-stranded DNA and require RNA-guided proteins such as Cas9 to
Friedrich Fauser, Bhakti N. Kadam, Sebastian Arangundy-Franklin, Jessica E. Davis, Vishvesha Vaidya, Nicola J. Schmidt, Garrett Lew, Danny F. Xia, Rakshaa Mureli, Colman Ng, Yuanyue Zhou, Nicholas A. Scarlott, Jason Eshleman, Yuri R. Bendaña, David A. Shivak, Andreas Reik, Patrick Li, Gregory D. Davis, Jeffrey C. Miller   +18 more
doaj   +1 more source

Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention

Frontiers in Pharmacology, 2020
With the objective of linking early findings relating to the novel SARS-CoV-2 coronavirus with potentially informative findings from prior research literature and to promote investigation toward therapeutic response, a coherent cellular and molecular ...
John P. Hussman
doaj   +1 more source

Photostimulated spin-flip and the photodynamic therapeutic effect of fullerene solutions [PDF]

arXiv, 2010
A new mechanism of photodynamic therapeutic effect of fullerene solution is suggested. Spin flip of electrons in oxygen molecule in the vicinity of negative-positive ion pair of fullerene lays the foundation of high oxidative activity of complexes C60(minus) -O2 and C60(plus)-O2.
arxiv  

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

HCI considerations in Designing a Second Life Virtual Therapeutic Community for the Support & Treatment of People with Borderline Personality Disorder [PDF]

arXiv, 2013
This paper aims to present the current position of the ongoing research into developing the requirements and acceptance of a virtual therapeutic community in Second Life, specifically for people with Borderline Personality Disorder (BPD). The research has identified this particular user group given that people with BPD often require high levels of ...
arxiv  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source