Results 81 to 90 of about 1,594,004 (375)
Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice
Nature CommunicationsHeart failure with preserved ejection fraction (HFpEF) poses therapeutic challenges due to the limited treatment options. Building upon our previous research that demonstrates the efficacy of histone deacetylase 6 (HDAC6) inhibition in a genetic ...
Sara Ranjbarvaziri +18 more
doaj +1 more source
The Pillars for Renal Disease Treatment in Patients with Type 2 Diabetes
Pharmaceutics, 2023 The diabetes epidemic and the increasing number of patients with diabetic chronic vascular complications poses a significant challenge to health care providers.
Jessica Kearney, Luigi Gnudi
doaj +1 more source
The Limitless Future of RNA Therapeutics
Frontiers in Bioengineering and Biotechnology, 2021 Recent advances in the generation, purification and cellular delivery of RNA have enabled development of RNA-based therapeutics for a broad array of applications.
T. Damase +5 more
semanticscholar +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Nature CommunicationsHypertrophic cardiomyopathy (HCM) affects approximately 600,000 people in the United States. Loss-of-function mutations in Myosin Binding Protein C3, MYBPC3, are the most common genetic cause of HCM, with the majority of mutations resulting in ...
Amara Greer-Short +29 more
doaj +1 more source
Cells, 2023 Cancer has become a global health hazard accounting for 10 million deaths in the year 2020. Although different treatment approaches have increased patient overall survival, treatment for advanced stages still suffers from poor clinical outcomes. The ever-
Aviral Kumar +6 more
doaj +1 more source
Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs [PDF]
, 2009 This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging.
Aird +75 more
core +1 more source
FEBS Letters, EarlyView.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source
WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis
Nature CommunicationsSynthetic lethality provides an attractive strategy for developing targeted cancer therapies. For example, cancer cells with high levels of microsatellite instability (MSI-H) are dependent on the Werner (WRN) helicase for survival.
Fernando Rodríguez Pérez +25 more
doaj +1 more source
Diversifying the structure of zinc finger nucleases for high-precision genome editing
Nature Communications, 2019 Genome editing often requires cleavage within a narrow sequence window. Here the authors develop an expanded set of zinc finger nuclease architectures that increase the available configurations by a factor of 64 and can target almost every base at loci ...
David E. Paschon +18 more
doaj +1 more source