Results 101 to 110 of about 116,006 (295)

Reversible and non-reversible thermal denaturation of lysozyme with varying pH at low ionic strength [PDF]

, 2013
DSC analysis has been used to quantify the reversibility of unfolding following thermal denaturation of lysozyme. Since the temperature at which protein unfolding occurs, Tm, varies with different solution conditions, the effect on the melting ...
McManus, Jennifer J., McManus, Jennifer, Blumlein, Alice   +2 more
core   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Thermal denaturation of bovine serum albumin and its oligomers and derivatives pH dependence.

, 1995
In a previous paper, we report a preliminary DSC study on bovine (BSA) and human (HSA) serum albumins. However, at accurate HPLC analysis the commercial proteins show three peaks: Fraction V-I, probably globulins (as declared by the producers), Fraction ...
C. DE SENA, D. FESSAS, P. TRAMONTI, G. GRAZIANO, GIANCOLA, CONCETTA, P. Del Vecchio, S. CAPASSO, C. Giancola, G. BARONE, DEL VECCHIO, POMPEA GIUSEPPINA GRAZIA   +9 more
core   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Irreversible thermal denaturation of human carbonic anhydrase [PDF]

Carbonic Anhydrase (CA; carbonate hydro-lyase, EC 4.2.1.1)), a zinc containing enzyme, catalyzes reversible hydration of carbon dioxide. This metalloenzyme is found in animals, photosynthesizing organisms, and in some nonphotosynthetic bacteria. Thermal
امانی, مجتبی, موسوی موحدی, علی اکبر, محرابی, معصومه, قبادی, سیروس, خدارحمی, رضا   +4 more
core  

Reversible thermal denaturation of immobilized chymotrypsinogen

, 1979
The reversible thermal denaturation of chymotrypsinogen A bound to the insoluble poly(2-hydroxyethyl methacrylate) Spheron matrix was investigated by the fluorescence method.
Eduard Brynda, Miroslav Bleha
core   +1 more source

Thermal denaturation of human haemoglobins [PDF]

Biochemical Journal, 1970
J, Kinderlerer, H, Lehmann, K F, Tipton
openaire   +2 more sources

Isotopic Effect on the Kinetic of Thermal Denaturation of Ceruloplasmin

Zeitschrift für Naturforschung C, 1985
Abstract The kinetics of thermal denaturation of ceruloplasmin in water and in water with different percentage of D20 in the temperature range 25 - 85 °C, following the optical density change of the 610 nm charge transfer band of the protein has been investigated.
SPORTELLI, Luigi, DESIDERI A., CAMPANIELLO A.   +2 more
openaire   +3 more sources

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Cardiolipin increases in chromatophores isolated from Rhodobacter sphaeroides after osmotic stress: structural and functional roles

Journal of Lipid Research, 2009
Chromatophores isolated from cells of Rhodobacter sphaeroides exposed to hypertonic solutions were enriched in cardiolipin (CL). Because CL levels are raised by increasing the incubation time of R.
Vincenzo De Leo, Lucia Catucci, Andrea Ventrella, Francesco Milano, Angela Agostiano, Angela Corcelli   +5 more
doaj   +1 more source