Results 111 to 120 of about 197,256 (299)

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Three-dimensional Middle Infrared Spectroscopy Study on Crystalline and Amorphous Structures and Thermostability of Corn, Wheat, and Pea Starch

Liang you shipin ke-ji
The structure and thermal denaturation of three types of starch, including corn starch, wheat starch, and pea starch, were studied using one-dimensional mid infrared (MIR) spectroscopy, temperature dependent one-dimensional MIR spectroscopy and two ...
KONG Xiao-mei, DU Lin-nan, JIANG Meng-wei, CHAI Jia-xin, CHANG Mei-ling, ZHANG Yong, CHANG Ming, XU Yuan-yuan   +7 more
doaj   +1 more source

Effect of thermal denaturation, inhibition, and cleavage of disulfide bonds on the low-frequency Raman and FTIR spectra of chymotrypsin and albumin [PDF]

, 2014
Н.Н. Брандт, Andrey Y. Chikishev, A.A. Mańkova, I.K. Sakodynskaya   +3 more
openalex   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Low-Temperature and High-Efficiency Solid-Phase Amplification Based on Formamide

Micromachines
The thermal stability of DNA immobilized on a solid surface is one of the factors that affects the efficiency of solid-phase amplification (SP-PCR).
Jialing Huang, Huan Li, Fengfeng Shu, Wenchao Zhou, Yihui Wu, Yue Wang, Xiao Lv, Ming Gao, Zihan Song, Shixun Zhao   +9 more
doaj   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Microcalorimetry reveals multi-state thermal denaturation of G. stearothermophilus tryptophanyl-tRNA synthetase. [PDF]

Struct Dyn, 2023
Chandrasekaran SN, Das J, Dokholyan NV, Carter CW.   +3 more
europepmc   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Improvement of fibrotic tissue flexibility using 450-nm fractional laser

Journal of Biomechanical Science and Engineering
Fibrosis is a condition resulting from tissue damage and inflammation that causes loss of function by hardening the tissue while accumulating collagen. Although there are drugs that inhibit the progression of fibrosis, there are few effective treatment ...
Ren SATO, Eiko KATO, Ippei YAGI, Satoshi UCHIDA   +3 more
doaj   +1 more source

Smart Hydrogel Doped by Metal–Organic Frameworks for Renewable Self‐Pumping Enzymatic Reactors

Advanced Science, EarlyView.
Renewable self‐pumping enzymatic reactors based on thermo‐stimulated cyclic contraction/expansion of metal‐organic frameworks‐doped hydrogel. Abstract The construction of high‐performance immobilized enzymes is vastly desired for green biotransformation.
Yuxi Zhu, Shenghao Wang, Yueyuan Luo, Linbo Cao, Xiuxiu Guo, Yue Zhang, Mingmin Li, Tie Wang   +7 more
wiley   +1 more source