Results 131 to 140 of about 2,719,034 (384)

Iron Oxide Nanoparticles Modified with Galloylated DNA for Magnetically Enhanced DNA‐Directed Assembly

open access: yesAdvanced Science, EarlyView.
A simple one‐step method is presented for DNA functionalization of iron oxide nanoparticles (IONP) using multidentate galloylated DNA. The DNA‐modified IONPs exhibit unique DNA binding properties of magnetically enhanced DNA interconnects. This study underscores the importance of nanoparticle (NP) effects in DNA sequence design and highlights the ...
Murali Golla   +6 more
wiley   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

open access: yesAdvanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu   +17 more
wiley   +1 more source

Three-dimensional Middle Infrared Spectroscopy Study on Crystalline and Amorphous Structures and Thermostability of Corn, Wheat, and Pea Starch

open access: yesLiang you shipin ke-ji
The structure and thermal denaturation of three types of starch, including corn starch, wheat starch, and pea starch, were studied using one-dimensional mid infrared (MIR) spectroscopy, temperature dependent one-dimensional MIR spectroscopy and two ...
KONG Xiao-mei   +7 more
doaj   +1 more source

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

open access: yesAdvanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo   +10 more
wiley   +1 more source

Low-Temperature and High-Efficiency Solid-Phase Amplification Based on Formamide

open access: yesMicromachines
The thermal stability of DNA immobilized on a solid surface is one of the factors that affects the efficiency of solid-phase amplification (SP-PCR).
Jialing Huang   +9 more
doaj   +1 more source

CD74 Blockade Disrupts Endothelial Migrasome Signaling to Prevent Inflammatory Macrophage Differentiation and Inhibit Atherosclerotic Progression

open access: yesAdvanced Science, EarlyView.
Migrasomes play a crucial role in endothelial‐immune interactions in atherosclerosis. This study identifies migrasomes as amplifiers in the inflammatory cascade, driving immune‐metabolic reprogramming via “migrasome‐APP‐CD74” signaling. Blocking CD74 disrupts migrasome‐mediated signaling, attenuating atherosclerosis progression.
Kangnan Zhang   +10 more
wiley   +1 more source

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