Results 71 to 80 of about 2,718,600 (295)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Universal approach to gravitational thermal effects

, 2003
A universal scheme for describing gravitational thermal effects is developed as a generalization of Unruh effect. Quasi-Rindler (QR) coordinates are constructed in an arbitrary curved space-time in such a way that the imaginary QR time be periodical. The
Audretsch, Birrell, Hawking, Mensky, Mensky, Mensky, Mensky, Mensky, Mensky, Michael B. Mensky, Roepstorff, Troost, Troost, Unruh, Unruh, Unruh   +15 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Influence of an abscisic acid (ABA) seed coating on seed germination rate and timing of Bluebunch Wheatgrass

Ecology and Evolution, 2019
Semi‐arid rangeland degradation is a reoccurring issue throughout the world. In the Great Basin of North America, seeds sown in the fall to restore degraded sagebrush (Artemisia spp.) steppe plant communities may experience high mortality in winter due ...
William C. Richardson, Turmandakh Badrakh, Bruce A. Roundy, Zackary T. Aanderud, Steven L. Petersen, Phil S. Allen, Dallin R. Whitaker, Matthew D. Madsen   +7 more
doaj   +1 more source

Non-exponential one-body loss in a Bose-Einstein condensate

, 2012
We have studied the decay of a Bose-Einstein condensate of metastable helium atoms in an optical dipole trap. In the regime where two- and three-body losses can be neglected we show that the Bose-Einstein condensate and the thermal cloud show ...
J. S. Borbely, R. van Rooij, S. Knoop, W. Vassen, Y. Kagan   +4 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Determinação do tempo térmico para o desenvolvimento de mudas de eucalipto na fase de enraizamento Determination of thermal time for the development of eucalyptus seedlings during rooting phase

Revista Brasileira de Engenharia Agrícola e Ambiental, 2012
O gênero Eucalyptus possui destaque em plantios florestais comerciais em virtude de apresentar crescimento rápido e ser adaptado às condições climáticas do Brasil.
Aline S. de Oliveira, Antonio J. Steidle Neto, Aristides Ribeiro, Nilton Jr. L. Rascon, Yhasmin P. Rody, André Q. de Almeida   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effects of Temperature on Seed Germination of Plantago lanceolata and Management in Carya illinoinensis Production

Plants, 2019
Plantago lanceolata L. (buckhorn plantain) is an encroaching winter weed described as one of the most successful noncultivated colonizing species around the world. Control of P. lanceolata in southeastern USA Carya illinoinensis (Wangenh.) K.
Timothy L. Grey, Kayla M. Eason, Lenny Wells, Nicholas T. Basinger   +3 more
doaj   +1 more source

The Time in Thermal Time

Journal for General Philosophy of Science
Accepted for publication in the Journal for General Philosophy of Science, as part of the Special Issue: On Time in the Foundations of Physics (eds. Andrea Oldofredi & Cristian Lopez).
openaire   +3 more sources