Results 111 to 120 of about 39,448 (266)

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

open access: yesCell Proliferation, EarlyView.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng   +4 more
wiley   +1 more source

Thermogenic Adipocytes Promote M2 Macrophage Polarization through CNNM4‐Mediated Mg Secretion

open access: yesAdvanced Science
M2 macrophages promote adipose tissue thermogenesis which dissipates energy in the form of heat to combat obesity. However, the regulation of M2 macrophages by thermogenic adipocytes is unclear.
Anke Zhang   +19 more
doaj   +1 more source

Maternal Organ Growth: How the Adult Intestine Remodels During Pregnancy and Lactation

open access: yesDevelopment, Growth &Differentiation, EarlyView.
ABSTRACT Adult organs exhibit remarkable plasticity, dynamically adjusting their size and function to meet physiological demands. The small‐intestinal epithelium, one of the most rapidly renewing tissues in mammals, undergoes extensive growth and remodeling in response to diet, injury, microbiota changes, and reproduction.
Tomotsune Ameku
wiley   +1 more source

Body Temperature Regulation in the Rat by Muscle Tone. [PDF]

open access: yesActa Physiol (Oxf)
ABSTRACT Aim We have previously described an important role of skeletal muscle tone in body temperature regulation, muscle tone defined as the tonic motor unit activity recorded between movements. Here, we study muscle tone in an extensive sample of new muscles outside (external muscles) and inside (internal muscles) the body core.
Njå A, Lømo T.
europepmc   +2 more sources

Protoplast-Based Transient Expression Combined with Plant Cultivation Systems as a Valuable Tool for Floral Thermogenesis Studies in Aroids [PDF]

open access: green, 2021
Haruhiko Maekawa   +5 more
openalex   +1 more source

Heart matters: How glucose‐ and lipid‐modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and the visceral pericardium, exerting direct paracrine and vasocrine effects on the heart and coronary vessels. Under physiological conditions, EAT supports myocardial energy metabolism and thermoregulation through fatty acid supply and
Elisabeth Heuboeck   +2 more
wiley   +1 more source

Assessing the interaction of the UCP system and fatty acids on epicardial adipose tissue mitochondrial respiration

open access: yesEuropean Journal of Clinical Investigation, EarlyView.
Epicardial adipose tissue (EAT) demonstrates higher mitochondrial activity than subcutaneous fat (SAT), particularly in NADH‐ and FAO‐linked oxidative phosphorylation (OXPHOS). While EAT expresses more UCP1, its inhibition by GDP minimally affects respiration, especially in FAO pathways, suggesting UCP1‐independence. Diabetes mellitus (DM) and coronary
Diana Santos   +12 more
wiley   +1 more source

Genomic Prediction and Genome‐Wide Association Analysis of Heat Tolerance for Milk Yield in Buffaloes Using a Reaction Norm Model

open access: yesJournal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The aim of this study was to evaluate the impact of incorporating genomic information on the estimation of genetic (co)variance components and the accuracy of breeding values for milk yield under varying thermal environments, and to identify SNPs associated with genes that play significant roles in heat tolerance.
Gabriela Stefani   +3 more
wiley   +1 more source

Giants in the cold: Morphological evidence for vascular heat retention in the viscera but not the skeletal muscle of the basking shark (Cetorhinus maximus)

open access: yesJournal of Fish Biology, EarlyView.
Abstract Fewer than 50 of the over 30,000 extant species of fishes have developed anatomical specializations facilitating endothermy in specific body regions. The plankton‐feeding basking shark (Cetorhinus maximus), traditionally classified as an ectotherm, was recently shown to have regionally endothermic traits such as centralized red muscle (RM ...
C. Antonia Klöcker   +9 more
wiley   +1 more source

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