Results 121 to 130 of about 45,421 (286)
Molecular MetabolismObjective: Defective activity of brown adipose tissue (BAT) is linked to obesity and cardiometabolic diseases. While much is known regarding the biological signals that trigger BAT thermogenesis, relatively little is known about the repressors that may ...
Albert Blasco-Roset +11 more
doaj +1 more source
Mechanism of Cold-induced Thermogenesis
, 2017 Cold-induced thermogenesis is an energy-demanding process that protects warm-blooded animals against reductions in ambient temperature. Villanueva and colleagues demonstrated that in response to cold, the liver switches metabolism to provide ...
Villanueva C.J.
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Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims This post hoc analysis evaluated the effect of survodutide on beta‐cell function, insulin sensitivity, and glucose biomarkers in two phase 2 trial populations. Materials and Methods Trial 1404‐0002 randomised 413 participants with type 2 diabetes on metformin to receive survodutide, placebo, or semaglutide over 16 weeks.
Elif I. Ekinci +5 more
wiley +1 more source
Nonshivering thermogenesis and its adequate measurement in metabolic studies
, 2011 Summary Alterations in nonshivering thermogenesis are presently discussed as being both potentially causative of and able to counteract obesity.
Nedergaard, Jan, +3 more
core +1 more source
The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes
The FEBS Journal, EarlyView.Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova +12 more
wiley +1 more source
Thermogenic Adipocytes Promote M2 Macrophage Polarization through CNNM4‐Mediated Mg Secretion
Advanced ScienceM2 macrophages promote adipose tissue thermogenesis which dissipates energy in the form of heat to combat obesity. However, the regulation of M2 macrophages by thermogenic adipocytes is unclear.
Anke Zhang +19 more
doaj +1 more source
, 2014 Проанализированы современные представления о механизмах продуцирования тепла (термогенеза) у семенных растений. У некоторых видов Araceae, Cycadaceae и Annonaceae, Nymphaeaceae, Aristolochiaceae, Arecaceae и Cyclanthaceae, Magnoliaceae, Nelumbonaceae
Подорванов, В.В.
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Ontogeny of non-shivering thermogenesis in Muscovy ducklings (Cairina moschata)
, 2014 International audienceIn precocial birds, developing the capacity for early regulatory thermogenesis appears as a fundamental prerequi- site for survival and growth in cold environments.
Roussel, Damien +3 more
core +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
MedCommPromoting thermogenesis in adipose tissue to enhance energy expenditure is widely regarded as a promising strategy for obesity treatment. However, the development of effective thermogenic drugs remains challenging.
Lang Chen +13 more
doaj +1 more source