Fast & fuelious: the malate–aspartate shuttle in brown adipocyte lipid metabolism
Brown adipose tissue (BAT) produces heat in response to cold exposure, for which it relies on the coordination of aerobic and anaerobic metabolism. However, how reaction intermediates connect these two essential pathways is unclear. In this issue of The FEBS Journal, Veliova et al., report that the malate–aspartate shuttle (MAS) supports norepinephrine‐
Lukas Blaas, Alexander Bartelt
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Leucine catabolic enzyme AUH regulates BAT thermogenesis via PPARγ HMGylation and RNA-binding function in male mice. [PDF]
Jiang H +13 more
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Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar +4 more
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Cross-Talk Between Signaling and Transcriptional Networks Regulating Thermogenesis-Insights into Canonical and Non-Canonical Regulatory Pathways. [PDF]
Simka-Lampa K.
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ABSTRACT Introduction Weight loss results in reduced energy expenditure (EE) due to body composition alterations (e.g., fat‐free mass and fat mass losses) and mass‐independent adaptations in EE (e.g., hormones). Glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are indicated for obesity management; however, their effects on EE remain unclear ...
Flavio T. Vieira +8 more
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Banksia attenuata (Proteaceae) attracts nocturnal scarab beetles with an unusual floral scent—the beetles pollinate the flower as they feed on pollen and nectar and mate on the inflorescences. Abstract Pollination by beetles has evolved multiple times in flowering plants but with relatively few plant species adapted specifically to pollination by ...
S. K. Wawrzyczek +8 more
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Thermogenic adipose tissue in older adults with obesity: a narrative review of mechanisms, brown fat resistance, and the translational relevance of exercise and nutrition. [PDF]
Wang F +5 more
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Deciphering Uncoupling Proteins in Cellular Homeostasis and Metabolic Health. [PDF]
Liu YT, Ding YJ, Qiu HL, Che Y, Tang QZ.
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Fueling or Fighting Cancer? The Thermogenic Paradox of Brown Adipose Tissue. [PDF]
Guerrero JJG +9 more
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