Results 161 to 170 of about 37,070 (254)

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 16, Page 4953-4968, August 2026.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus   +7 more
wiley   +1 more source

Proteomic and Super-Resolution Analyses of Murine Brown Adipocyte-Derived Extracellular Vesicles. [PDF]

open access: yesJ Extracell Biol
Quan M   +8 more
europepmc   +1 more source

Association of Physical Activity With All‐Cause and CVD Mortality Across Metabolic and Obesity Phenotypes

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7006-7017, August 2026.
ABSTRACT Aims To examine the independent and joint associations of metabolic status, obesity, and physical activity with all‐cause and cardiovascular disease (CVD) mortality across metabolic–obesity phenotypes. Materials and Methods We analysed 442 666 adults from the Korean National Health Insurance Service health screening cohort (2009–2012 ...
Yunmin Han   +3 more
wiley   +1 more source

A conserved hormonal signalling-H2A.Z axis rapidly reorganizes 3D chromatin interactions in adipocyte thermogenesis. [PDF]

open access: yesNat Metab
Zhang Y   +18 more
europepmc   +1 more source

Brain Serotonin Transporter Is Elevated in Obesity: Bayesian and Frequentist Meta‐Analyses

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6919-6926, August 2026.
ABSTRACT Aims The brain plays a critical role in controlling energy balance. Previous studies have mainly focused on dopaminergic mechanisms, whereas much less attention has been paid to serotonin during the emergence of overweight and obesity. Therefore, this study investigated the association between serotonin transporter (SERT) availability and ...
Kyoungjune Pak
wiley   +1 more source

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

open access: yesThe FEBS Journal, Volume 293, Issue 15, Page 4489-4507, August 2026.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova   +12 more
wiley   +1 more source

Intermittent Fasting: A Metabolically Focused Therapeutic Strategy for Obesity. [PDF]

open access: yesNutrients
Diaz-Garrido N   +4 more
europepmc   +1 more source

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