Results 161 to 170 of about 83,845 (311)

The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

The FEBS Journal, EarlyView.
Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira   +12 more
wiley   +1 more source

SKELETAL MUSCLE MITOCHONDRIAL OXIDATIVE CAPACITY AND UNCOUPLING PROTEIN 3 ARE DIFFERENTLY INFLUENCED BY SEMISTARVATION AND REFEEDING [PDF]

, 2003
CRESCENZO, RAFFAELLA, DULLOO AG, IOSSA, SUSANNA, LIVERINI, GIOVANNA, MAINIERI D, MONTANI JP, SEYDOUX J, SOLINAS G   +7 more
core   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission [PDF]

, 2019
Agrawal, Anyuan He, Aranovich, Babak Razani, Baes, Braverman, Cohen, Dodt, Fong-Fu Hsu, Gould, Hongsuk Park, Irfan J. Lodhi, John M. Dean, Jordan M. Johnson, Katsuhiko Funai, Lim, Min Tan, Terri A. Pietka, Wikstrom, Xiangyu Zhang, Yali Chen   +20 more
core   +2 more sources

Zc3h10 Acts as a Transcription Factor and Is Phosphorylated to Activate the Thermogenic Program. [PDF]

, 2019
Brown adipose tissue harbors UCP1 to dissipate chemical energy as heat. However, the transcriptional network that governs the thermogenic gene program is incompletely understood. Zc3h10, a CCCH-type zinc finger protein, has recently been reported to bind
Dempersmier, Jon, Dinh, Jennie, Nguyen, Hai, SUL, Hei Sook, Tabuchi, Chihiro, Viscarra, Jose, Wang, Yuhui, Yi, Danielle   +7 more
core  

Unravelling the Genetic Mechanisms of Litter Traits in a Maternal Line of Pigs

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Reproductive traits related to litter size are the main indicators of reproductive efficiency in pig production and are continuously evaluated for the selection of maternal lines. Several environmental and genetic factors are involved with the development of these traits.
Guilherme Oselame, Suelen Fernandes Padilha, Maurício Egídio Cantão, Jane de Oliveira Peixoto, Aline Zampar, Adriana Mércia Guaratini Ibelli, Luis Orlando Duitama Carreño, Jader Silva Lopes, Pedro Henrique Ferreira Freitas, Marcelo Silva Freitas, Mônica Corrêa Ledur   +10 more
wiley   +1 more source

Giants in the cold: Morphological evidence for vascular heat retention in the viscera but not the skeletal muscle of the basking shark (Cetorhinus maximus)

Journal of Fish Biology, EarlyView.
Abstract Fewer than 50 of the over 30,000 extant species of fishes have developed anatomical specializations facilitating endothermy in specific body regions. The plankton‐feeding basking shark (Cetorhinus maximus), traditionally classified as an ectotherm, was recently shown to have regionally endothermic traits such as centralized red muscle (RM ...
C. Antonia Klöcker, Axel Schlindwein, Martin C. Arostegui, Ingrid M. Bruvold, Joel V. Wernström, Montserrat Martin‐Armas, David W. Sims, Nicolas Straube, Andreas Altenburger, Claudia Junge   +9 more
wiley   +1 more source

Diagnosing and Treating Periodontitis and Multimorbidity Altogether: The Case Example of the Physical Exercise Hormone Irisin

Journal of Periodontal Research, EarlyView.
Irisin is an extracellular peptide stimulated by exercise and could act as both a biomarker and mediate the positive impact of exercise. This scoping review synthesizes human evidence on irisin variations in non‐communicable diseases, showing an increase of irisin in saliva and gingival tissues in periodontitis, potentially reflecting reparative or ...
Larysa Saboya Cavalotti Perdonsini, Rafael Scaf de Molon, Søren Jepsen, Iain Chapple, Joao Paulo Steffens   +4 more
wiley   +1 more source

Thermogenic Adipocytes Promote M2 Macrophage Polarization through CNNM4‐Mediated Mg Secretion

Advanced Science
M2 macrophages promote adipose tissue thermogenesis which dissipates energy in the form of heat to combat obesity. However, the regulation of M2 macrophages by thermogenic adipocytes is unclear.
Anke Zhang, Junkun Jiang, Chuan Zhang, Houshi Xu, Wenjing Yu, Zhen‐Ning Zhang, Ling Yuan, Zhangming Lu, Yuqing Deng, Haonan Fan, Chaoyou Fang, Xiaoyu Wang, Anwen Shao, Sheng Chen, Huaming Li, Jiahua Ni, Wenhui Wang, Xiaonong Zhang, Jianmin Zhang, Bing Luan   +19 more
doaj   +1 more source

Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet.

Physiology and Behavior, 2017
P. E. Bunney, A. Zink, A. Holm, C. Billington, C. Kotz   +4 more
semanticscholar   +1 more source