Results 81 to 90 of about 68,485 (306)

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source

A Third Variable in Obesity: The Effects of Brown Adipose Tissue on Thermogenesis

, 1981
Approaches to weight management which consider only energy intake and/or expenditure do not consistently lead to favorable outcomes. A third variable, thermogenesis, must also be considered in a comprehensive understanding of obesity· Three types of ...
McMinn, Mark R.
core  

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy

Journal of Advanced Research
Introduction: Promoting adipose thermogenesis is considered as a promising therapeutic intervention in obesity. However, endeavors to develop anti-obesity medications by targeting the canonical thermogenesis regulatory pathway, particularly β3-adrenergic
Sijia Lu, Quanxin Jiang, Peihui Zhou, Limin Yin, Ning Wang, Junting Xu, Qiqi Qian, Mijia Tao, Hanrui Yin, Liu Han, Yunqing Gu, Fei Gao, Junli Liu, Suzhen Chen   +13 more
doaj   +1 more source

Comparative aspects of resistance to body-cooling in newborn lambs and kids : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science in Animal Science at Massey University [PDF]

, 1989
THE PROBLEM OF PERINATAL MORTALITY IN LAMBS AND KIDS Fibre-producing goats are becoming an increasingly important species on New Zealand farms. There is a considerable lack of information about the physiology of goats, especially as it relates to the ...
Müller, Sabine
core  

Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk [PDF]

, 2019
BACKGROUND: Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα ...
Dong, Jiangling, Garibotto, Giacomo, Hruska, Keith, Hu, Zhaoyong, Mitch, William E, Thomas, Sandhya S, Verzola, Daniela, Wu, Jiao   +7 more
core   +2 more sources

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Repeatability of brown adipose tissue measurements on FDG PET/CT following a simple cooling procedure for BAT activation [PDF]

, 2019
Brown Adipose Tissue (BAT) is present in a significant number of adult humans and can be activated by exposure to cold. Measurement of active BAT presence, activity, and volume are desirable for determining the efficacy of potential treatments intended ...
Crandall, John P, Gajwani, Prateek, Mawhinney, Daniel D, O., Joo H, Sterzer, Fred, Wahl, Richard L   +5 more
core   +2 more sources