Results 191 to 200 of about 55,424 (301)

Special Issue: Novel Vaccines and Vaccine Technologies for Emerging Infections. [PDF]

Vaccines (Basel)
Chen W, Li X, Kamen AA.
europepmc   +1 more source

High‐Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor

MedComm, Volume 7, Issue 5, May 2026.
We conducted a high‐throughput screen of 2747 FDA‐approved drugs to identify inhibitors of pyroptosis. We found that CeeNU significantly repressed NLRP3‐dependent IL‐1β release and GSDMD pore‐forming complex. We identified that the arginine 335 amino acid of the NACHT domain of NLRP3 is the critical point for human NLRP3 and CeeNU interaction and ...
Sen‐Lin Ji, Peipei Chen, Huaiping Tang, Chao Zhou, Zihao Li, Yunshu Wang, Xiang Cao, Liwen Zhu, Xinyu Bao, Zhuo Liu, Yan Chen, Yun Xu   +11 more
wiley   +1 more source

Cysteine Pegylation of a Mutant L-asparaginase Affords Enhanced Activity and Thermostability. A Comparative Study Against N-terminal Conjugation. [PDF]

Appl Biochem Biotechnol
Ferraro RB, Benevides GR, Rabelo J, da Silva Chaves F, Ruiz-Lara GV, Carretero G, Monteiro G, Pessoa-Junior A, Converti A, Lynham S, Long PF, Rangel-Yagui CO.   +11 more
europepmc   +1 more source

Phenolic Compounds: From Traditional Uses to Innovative Applications and Everything in Between

Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
This review deals with many aspects related to the study of phenolic compounds, starting with advances in extraction, detection, and quantification methods, going through bioavailability, bioactivity, and beneficial health properties, and discussing antioxidant and antimicrobial uses and mechanisms.
Marcela de Sá Barreto da Cunha, Cristina Maria Turim Santos Miguel, Emília Maria França Lima, Uelinton Manoel Pinto, Cláudia Vieira Prudêncio, Svetoslav Dimitrov Todorov   +5 more
wiley   +1 more source

Bioinformatics based design of thermostable virus-like particles-based vaccine for foot-and-mouth disease serotype A and <i>in-vivo</i> evaluation in guinea pigs. [PDF]

Front Cell Infect Microbiol
Selvaraj DPR, Saravanan P, Madhavan A, Adwitiya D, Tilak C, Sreenivasa BP, Gopinath S, Elackiya S, Thiyagarajan S, Chaudhuri P.   +9 more
europepmc   +1 more source

Linking NrfD/PsrC‐like architecture to energy conservation: Functional residues in the quinone reactive QrcABCD complex of sulfate‐reducing bacteria

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The QrcABCD quinone reductase complex is an electrogenic complex present in sulfate‐reducing bacteria of the Desulfobacterota phylum. It operates as a cytochrome c3:menaquinone oxidoreductase involved in electron transfer from periplasmic hydrogen or formate oxidation to the menaquinone (MK) pool.
Gonçalo Manteigas, Teresa Catarino, João B. Vicente, Américo G. Duarte, Inês A. C. Pereira   +4 more
wiley   +1 more source

Ginkgo Datapoints Antibody Developability Competition outcomes: limited model performance and a call for data standardization. [PDF]

MAbs
van Niekerk L, Moller J, Ritter S, Quintero-Cadena P, Cohen R, Channing G, Chungyuon M, Rand L, Smith A, Bhatt A, Pierre Y, Harris B, Ao X, Grippo L, Schwenk M, Rosenbaum A, Allen O, Asi N, Zhu J, Singh A, Sammi D, Jadhav R, Dušek A, Chandra S, Badea V, Thorsteinson N, Blalock N, Kim J, Turnbull OM, Kulkarni A, Kohar V, Gebremedhin N, Deane CM, Tessier PM, Arsiwala A.   +34 more
europepmc   +1 more source

Novel GH115 xylan α‐1,2‐glucuronidases with distinct preferences for xylan‐derived oligomers and polymers

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Natural polymers are promising sustainable materials for diverse applications. Xylans, major components of hemicellulose, exhibit origin‐dependent substitution patterns that determine their physicochemical properties. Targeted enzymatic modification of these substituents offers a mild and precise approach for tailoring the polymer's ...
Savvina Leontakianakou, Simone Balzer Le, Anders Sundin, Andrius Jasilionis, Giang‐Son Nguyen, Anna Nordborg, Lalitha D. Gottumukkala, Carl Grey, Anna Sofia Lewin, Eva Nordberg Karlsson   +9 more
wiley   +1 more source

Thermostable Proteases from <i>Geobacillus</i>: Production, Characterization, Structural Stability Mechanisms and Biotechnological Applications. [PDF]

Microorganisms
Wang M, Wang JW, Cheng JH.
europepmc   +1 more source

ATP modulates holdase activity of fungal and human 110‐kilodalton heat shock proteins to promote protein folding

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Heat shock proteins of the 70‐kDa family (Hsp70s) are highly abundant and conserved molecular chaperones that help preserve proteostasis primarily by facilitating proper protein folding. Heat shock protein of the 110‐kDa family (Hsp110s), a specialized branch of the Hsp70/Hsp110 superfamily, function both as nucleotide exchange factor (NEF ...
Justin M. Kidd, Cancan Sun, Alissa Garay, Mitchell Keplinger, Colin Richter, Aaron E. May, Qinglian Liu   +6 more
wiley   +1 more source