Results 181 to 190 of about 38,411 (253)

Predicting Functional Diversity Within Enzyme Families: A Practical Perspective

ChemBioChem, Volume 27, Issue 19, 14 October 2026.
Integrating machine learning into enzyme discovery requires navigating the trade‐offs between data quantity and quality. This article provides a best‐practice framework for developing robust predictors, focusing on mitigating bias in biochemical datasets, implementing systematic “cold‐drug” validation strategies, and utilizing explainable artificial ...
Nika Sokolova, Kristina Haslinger
wiley   +1 more source

Advances in Carrageenases: Molecular Engineering, Immobilization Techniques, and Biomedical Potential of Carrageenan Oligosaccharides. [PDF]

Mar Drugs
Xie Q, Lan J, Chen Y, Li Z, Li L, Jiang Z, Ni H, Zhu Y.   +7 more
europepmc   +1 more source

Enhancing Enzyme Activity With Mutation Combinations Guided by Few-Shot Learning and Causal Inference. [PDF]

Angew Chem Int Ed Engl
Guo L, Yan X, Lu Y, Nie S, Ge M, Li Y, Li W, Zhang X, Liang D, Zhao Y, Tan H, Chen X, Fan S, Tang Y, Qiao J, Tian B.   +15 more
europepmc   +1 more source

Genome-Resolved Metagenomics Reveals Thermophilic Microbial Diversity and Putative Hydrolase-Encoding Genes in the El Tatio Geothermal Field. [PDF]

Int J Mol Sci
Valenzuela B, Navarrete-Diaz I, Cayo M, Solís-Cornejo F, Zamorano P.   +4 more
europepmc   +1 more source

Reengineering a thermostable keratinase past the boiling point. [PDF]

Appl Environ Microbiol
Jenney FE.
europepmc   +1 more source

Identification of thermostability-enhancing mutations in H9N2 avian influenza virus hemagglutinin. [PDF]

J Virol
Liu B, Yu H, Yan Z, Zou S, Guo J, Cai S, Hu Y, Yang Y, Yan Y, Liu H, Mei K, Li Z, Qin L, Li Y, Huang S, Wen F.   +15 more
europepmc   +1 more source

Metal–Organic Framework‐Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction

Advanced Materials, Volume 38, Issue 55, 1 October 2026.
By growing a conformal ZIF‐8 protective layer directly on antibody‐functionalized microneedles, this work converts a fragile biosensing interface into a thermostable diagnostic platform. The MOF@MN patch enables minimally invasive NGAL detection from dermal ISF while supporting cold‐chain‐independent storage and transport for decentralized kidney ...
Yixuan Wang, Ying Liu, Avishek Debnath, Chuang Li, Zheyu Wang, Gayathri Kondepati, Saketh Balmoori, Jeremiah J. Morrissey, Ying Maggie Chen, Limei Tian, Srikanth Singamaneni   +10 more
wiley   +1 more source

Keap1-Kelch-targeting protein-protein interaction inhibitors, but not reversibly-binding electrophiles, increase the thermostability of Keap1 in the cellular environment. [PDF]

RSC Chem Biol
Dayalan Naidu S, Dikovskaya D, Walker JM, Yee CLJ, Cafferkey AJ, Tatsuno M, Feng J, Moore TW, Johnson T, Honda T, Wells G, Suzuki T, Yamamoto M, Dinkova-Kostova AT.   +13 more
europepmc   +1 more source

Suitable Substrates for Black Soldier Fly Larvae Production: A Pathway Towards Sustainable Aquafeed Production

Aquaculture, Fish and Fisheries, Volume 6, Issue 5, October 2026.
ABSTRACT Due to the rapid growth in aquaculture, there is an urgent need to explore alternative sustainable sources for fish feed other than conventional fishmeal. Black soldier fly larvae (BSFL) have been identified as a potential source of protein that could transform waste materials into high‐value biomass. This review critically synthesizes current
Mekonnen Melesse, Abebe Getahun, Akewake Geremew   +2 more
wiley   +1 more source

Thermostable ancestors enabled evolutionary diversification of promiscuous chemical defence enzymes. [PDF]

EMBO J
Thomson RES, Gumulya Y, Bengochea AW, Foley G, Zaugg J, Aagaard A, Ross CM, Beckett J, Bodén M, Jurva U, Hayes MA, Andersson S, Gillam EMJ.   +12 more
europepmc   +1 more source