Results 61 to 70 of about 40,909 (278)

RNomics of Thermus themophilus HB8 by DNA microarray and next-generation sequencing [PDF]

, 2017
By using the data obtained by the DNA microarray analysis for the intergenic regions applied to RNA samples extracted from Thermus thermophilus HB8, seven small non-coding RNAs, TtR-1 to TtR-7, were found to be expressed in the cells growing in rich and ...
Gen-ichi Sampei, Gota Kawai, Maina Otsu, Naomi Koike, Yuri Aoki   +4 more
core   +2 more sources

LIBX‐A401: A Novel Selective Inhibitor of Acyl‐CoA Synthetase Long Chain Family Member 4 (ACSL4) and Its Binding Mode

Angewandte Chemie, Volume 137, Issue 19, May 5, 2025.
The discovery of LIBX‐A401, a potent and selective ACSL4 inhibitor derived from rosiglitazone is reported. HDX‐MS reveals that LIBX‐A401 stabilizes the ACSL4 C‐terminus and alters the fatty acid (FA) gate domain. Consistently, photoaffinity labeling, molecular dynamics, and mutagenesis identify key binding residues within the FA pocket.
Darius Mazhari Dorooee, Séverine Ravez, Didier Vertommen, Nicolas Renault, Nicolas Papadopoulos, Romain Marteau, Emeline Charnelle, Karine Porte, Alexandre Gobert, Nathalie Hennuyer, Gaetan Herinckx, Maëla Pautric, Aurélie Jonneaux, Jean Christophe Devedjian, David Devos, Bart Staels, Patricia Melnyk, Stefan N. Constantinescu, Raphaël Frédérick, Jamal El Bakali   +19 more
wiley   +2 more sources

Studies of the ferredoxin from Thermus thermophilus.

Journal of Biological Chemistry, 1983
The soluble ferredoxin from Thermus thermophilus was examined by Mössbauer and EPR spectroscopies and by reductive titrations. These studies demonstrate the presence of one 3Fe center, responsible for the characteristic g = 2.02 EPR signal in the oxidized protein, and one [4Fe-4S] center which is responsible for the rhombic EPR spectrum of the fully ...
T A Kent, James A. Fee, E Münck, Russ Hille, Tatsuro Yoshida, B.H. Huynh, C H Williams, Martha L. Ludwig, G E Tarr   +8 more
openaire   +3 more sources

Cloning of the Thermus thermophilus methionine aminopeptidase gene and confirmation of the enzyme functional activity

Acta Biomedica Scientifica
Background. Methionine aminopeptidases (MAPs) are a class of enzymes that catalyze the removal of the N-terminal initiator methionine from a polypeptide chain.
V. V. Bykov, A. A. Vologzhannikova, M. V. Trunilina, T. A. Kudryashov, A. S. Sokolov, Yu. S. Lapteva   +5 more
doaj   +1 more source

Complete Genome Sequencing of Thermus thermophilus Strain HC11, Isolated from Mine Geyser in Japan

Microbiology Resource Announcements, 2019
Thermus thermophilus strain HC11 was isolated from Mine Geyser in Japan, where type strain HB8 was isolated 50 years ago. In this article, the complete genome sequence of HC11 is presented.
K. Miyazaki
semanticscholar   +1 more source

Building Proteins in a Day: Efficient 3D Molecular Reconstruction

, 2015
Discovering the 3D atomic structure of molecules such as proteins and viruses is a fundamental research problem in biology and medicine. Electron Cryomicroscopy (Cryo-EM) is a promising vision-based technique for structure estimation which attempts to ...
Brubaker, Marcus A., Fleet, David J., Punjani, Ali   +2 more
core   +1 more source

Complete Genome Sequences of Thermus thermophilus Strains AA2-20 and AA2-29, Isolated from Arima Onsen in Japan

Microbiology Resource Announcements, 2019
We isolated halophilic and thermophilic Thermus thermophilus strains AA2-20 and AA2-29 from nonvolcanic, oceanic Arima Onsen (hot spring) in Japan. Here, we report the complete genome sequences of these organisms to gain insights into halophilicity ...
K. Miyazaki, Natsuki Tomariguchi
semanticscholar   +1 more source

Structural insights into RNA processing by the human RISC-loading complex. [PDF]

, 2009
Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC).
AD Haase, B Kastner, Bunpote Siridechadilok, C Matranga, Cameron Noland, David W Taylor, DS Schwarz, E Bernstein, E Ma, EF Pettersen, Enbo Ma, Eva Nogales, F Herzog, FV Rivas, H Gao, Hong-Wei Wang, IJ MacRae, IJ MacRae, IJ MacRae, JB Preall, Jennifer A Doudna, JJ Song, Karin Felderer, KH Kok, M Högbom, M Radermacher, M van Heel, PA Penczek, SH Scheres, SJ Ludtke, T Sasaki, TA Rand, TM Rana, TP Chendrimada, W Wriggers, Y Lee, Y Tomari, Y Tomari, Y Wang, Y Wang, YR Yuan, YR Yuan   +41 more
core   +2 more sources

Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes

Angewandte Chemie International Edition, EarlyView.
The highly negatively charged phosphodiester groups of nucleic acids and cyclic (di‐)nucleotides often interact with amino acids containing polar or positively charged sidechains. Due to charge repulsion with their negatively charged carboxylate groups in their side chains, glutamate and aspartate are considered to be detrimental to such interactions ...
Konstantin Neißner, Elke Duchardt‐Ferner, Christoph Wiedemann, Julian Kraus, Ute A. Hellmich, Jens Wöhnert   +5 more
wiley   +1 more source

The transjugation machinery of Thermus thermophilus: Identification of TdtA, an ATPase involved in DNA donation

PLoS Genetics, 2017
In addition to natural competence, some Thermus thermophilus strains show a high rate of DNA transfer via direct cell-to-cell contact. The process is bidirectional and follows a two-step model where the donor cell actively pushes out DNA and the ...
A. Blesa, Ignacio Baquedano, N. Quintáns, C. Mata, J. R. Castón, J. Berenguer   +5 more
semanticscholar   +1 more source