Results 21 to 30 of about 806 (175)
Photochemical Ring Editing: Access to Privileged 1,2,5-Thiadiazole Scaffolds via Efficient Carbon Excision from Thiadiazines Under Ambient, Aerobic Conditions [PDF]
, 2022 Thiadiazoles are a privileged motif in medicinal chemistry, however selective mono-oxidation of the endocyclic sulfur, without over oxidation, is challenging.
Panayiotis A., Koutentis +12 more
core +2 more sources
, 2016 Four bicyclic 4H-[1,2,4]thiadiazines 1a−d were prepared in 74−88% yields in two steps from the corresponding amidines 2. Three of them, 1a, 1b, and 1d, were obtained by thermal elimination of propene from the intermediate S-propylsulfilimines 12.
Victor G. Young (1405513) +2 more
core +4 more sources
, 2022 A highly regioselective inverse electron-demand aza-Diels–Alder reaction of α,β-unsaturated thioesters with 1,2-diaza-1,3-dienes generated in situ from α-halogeno hydrazones was developed.
Yong You +11 more
core +1 more source
Thiadiazine Derivatives as Antiprotozoal New Drugs [PDF]
The Open Medicinal Chemistry Journal, 2011 The 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione scaffold have found many applications in recent years. This review is aimed at highlighting the most important aspects about these compounds: synthesis, spectroscopic characterization and antiprotozoan activities.
Bermello, Julieta Coro +4 more
openaire +2 more sources
Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
Chemistry Proceedings, 2023 Heterocyclic derivatives of hormones have attracted great interest as a privileged scaffold for drug discovery due to their outstanding biological activity.
Yulia Volkova +2 more
doaj +1 more source
Molecules, 2020 A new effective method for the construction of nitrogen heterocycles incorporating endocyclic pharmacophore sulfonamide fragment, based on the use of easy accessible N-(chlorosulfonyl)imidoyl chloride, CCl3C(Cl)=NSO2Cl (1), has been developed.
Oleksandr Shalimov +3 more
doaj +1 more source
Molecules, 2015 The high yielding transformations of 3,4,4,5-tetrachloro-4H-1,2,6-thiadiazine into 3,5-dichloro-4H-1,2,6-thiadiazin-4-one (up to 85%) and 2-(3,5-dichloro-4H-1,2,6-thiadiazin-4-ylidene)malononitrile (up to 83%) have been investigated and compared to the ...
Andreas S. Kalogirou +1 more
doaj +1 more source
SYNTHESIS OF 2-SUBSTITUTEDGUANIDINO-4-SUBSTITUTED-IMINE-6-SUBSTITUTEDIMINO-1,3,5-THIADIAZINES [PDF]
, 2017 A novel series of 2-substitutedguanidino-4-substitutedimine-6-sub-stitutedimino-1,3,5- thiadiazines (IIIa1 -e 5 ) have been recently synthesized by refluxing N-methylformamidino-N’- phenyliminothiocarbamide also called as 1-(N-substitutedcarbamimidoyl)3-{
P. V. Raut*, P. S. Bodakhe, S. A. Waghmare, D. T. Tayade
core +1 more source
Synthesis of 3,4-Dihydro-2H-1,3,5-thiadiazines
, 2016 3,4-Dihydro-2H-1,3,5-thiadiazines substituted at the 3 and 6 positions were synthesized by treatment of N-substituted N,N-bis(1H-1,2,3-benzotriazol-1-ylmethyl)-amines with thioamides and zinc bromide in dry CH2Cl2 at room temperature for 48−60 h in 48−80%
Peter J. Steel (1724674) +3 more
core +1 more source
3,5-Bis(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one
Molbank, 2012 3,5-Dichloro-4H-1,2,6-thiadiazin-4-one 1 reacts with (4-dodecylthiophen-2-yl)trimethylstannane 4 (2.2 equiv.) and Pd(Ph3P)2Cl2 (5 mol%) in acetonitrile at ca. 82 °C to give 3,5-bis(4-dodecylthiophen-2-yl)-4H-1,2,6-thiadiazin-4-one 5 in 93% yield.
Panayiotis A. Koutentis +1 more
doaj +1 more source