Results 111 to 120 of about 10,659 (219)

Novel Inhibitors for MDM2-MDM4 E3 Ligase Potently Induce p53-Indepedent Apoptosis in Drug-Resistant Leukemic Cells

Molecules
MDM2 and MDM4 are major negative regulators of tumor suppressor p53. Beyond regulating p53, MDM2 possesses p53-independent activity in promoting cell cycle progression and tumorigenesis via its RING domain ubiquitin E3 ligase activity. MDM2 and MDM4 form
Rati Lama, Joseph M. Fose, Diana Martín, Inés G. Muñoz, Eunice S. Wang, Pamela J. Sung, Sherry R. Chemler, Xinjiang Wang   +7 more
doaj   +1 more source

A REVIEW ON THE VARIOUS BIOLOGICAL ACTIVITIES OF THIADIAZOLE [PDF]

, 2015
Thiadiazole and their derivatives have been studied colossally because of their wide range of biological activity. They are found to be effectual as antibacterial, antimalarial, antiviral, antiinflammatory, anticancer and antianthelminthic agents ...
Neetu, Taya, Poonam, Mehta, Dinesh
core  

Retraction: Molecular docking and <i>in vivo</i>/<i>in vitro</i> studies of a novel thiadiazole Schiff base as a hepatoprotective drug against angiogenesis induced by breast cancer. [PDF]

RSC Adv
Alqahtani NF, Alfaifi MY, Shati A A, Elbehairi SEI, Saleh AM, Kotb ES, Serag WM, Elshaarawy RFM, Alhamdi HW, Hassan YA.   +9 more
europepmc   +1 more source

A Multi-Target Nitrogen-Fused Azole Drug Platform Derived from a Pyrazoline-Thiadiazole Moiety: In Vivo Antimicrobial Validation and Comprehensive Anticancer Investigation Supported by Computational Studies. [PDF]

Pharmaceutics
El-Hema HS, Abed MA, Hawata MA, Nossier ES, Altwaijry NA, Saleh A, Hassan M, Hashem RA, Hussein MF, Elhendawy AT, Abdel-Rahman AA.   +10 more
europepmc   +1 more source

Synthesis, Antidepressant-like and Anxiolytic-like Effects of Novel Thiadiazole Derivatives: Behavioral Assessment and Mechanistic Investigation. [PDF]

Pharmaceuticals (Basel)
Kandemir Ü, Türkoğlu Sağlık G, Osmaniye D, Kaplancıklı ZA, Can ÖD, Demir Özkay Ü.   +5 more
europepmc   +1 more source

Synthesis, characterization, molecular docking and in vitro anti-arthritic activity of some novel spiro [1,3,4] thiadiazole derivatives based on thioxoacetamides. [PDF]

BMC Chem
El-Saghier AM, Abdul-Baset A, El-Hady OM, Abdou A, Hamed AM, Kadry AM.   +5 more
europepmc   +1 more source

Thiadiazole-azetidinone sulfonamide hybrids with antimycobacterial activity supported by structure-based analysis. [PDF]

RSC Adv
Vishwakarma SK, Mishra A, Panigrahi N, Roque-Borda CA.   +3 more
europepmc   +1 more source

Development of a Late-Stage Functionalization Strategy to Access Diverse 3,5-Disubstituted 1,2,4-Thiadiazoles. [PDF]

J Org Chem
Dobria A, Petros ZA, Mickel P, Aldrich LN.   +3 more
europepmc   +1 more source

Synthesis, biological activities, DFT, and molecular docking of 1,3,4-thiadiazolo[2,3-c]-1,2,4-triazine-Palladium (II) complex. [PDF]

Sci Rep
Hassan SS, Dawood KM, Abubakr AS, Mahmoud NS, Kheder NA.   +4 more
europepmc   +1 more source

Corrosion inhibition of ductile iron in hydrochloric acid using 5-amino-1,3,4-thiadiazole-2-thiol: electrochemical and computational studies. [PDF]

Sci Rep
Helmy M, El-Zomrawy AA, Mogoda AS, Nasser A, Mahmoud M, Mohamed TA.   +5 more
europepmc   +1 more source