Results 91 to 100 of about 11,765 (225)

Development of Benzothiophene–Bearing Bis–oxadiazole Derivatives for Potential Anticancer Targets: Evaluation of DFT, ADME–Tox, and In Silico Docking

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Innovative synthesis of a novel benzothiophene–based bis–oxadiazole derivatives. The structural characterization was performed using experimental and theoretical methods. Significant anticancer activity against selected cancer cell lines. Three derivatives showed good activity 7b, 7g and 7i with IC50 values 7.5 ± 1.04 and 9.5 ± 1.01 µg/mL.
Nagaraju Madala, Vishal Sharma, Srilalitha Vinnakota   +2 more
wiley   +1 more source

Green Acid Mediated Synthesis of Imidazo[1,2‐a]Pyrimidine–Thiazole/1,3,4‐Thiadiazole Hybrids: Design, Characterization and In‐Vitro Biological Evaluation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
A new set of imidazo[1,2‐a]pyrimidine‐thiazole/thiadiazole hybrids were developed through the molecular hybridization concept. The thiazole and thiadiazole derivatives were synthesized using water as a solvent, and the final compounds were synthesized using citric acid as an eco‐friendly catalyst.
Dinesha P, Shivakumar Naik, Udayakumar D, Maithilee S. Dhekale, Sampat Parayya Vibhutimath, Rajkumar Reddy Rajula, Revanasiddappa B.C, Nanditha Bhat, Naveena S. Veeranagaiah   +8 more
wiley   +1 more source

Synthesis and Anti-Trypanosoma cruzi Activity of New Pyrazole-Thiadiazole Scaffolds

Molecules
Chagas disease, a silent but widespread disease that mainly affects a socioeconomically vulnerable population, lacks innovative safe drug therapy. The available drugs, benznidazole and nifurtimox, are more than fifty years old, have limited efficacy, and
Thamyris Perez de Souza, Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Vitoria Barbosa Paes, Lucas Penha Dutra, Mauricio Silva dos Santos, Mirian Claudia de Souza Pereira   +6 more
doaj   +1 more source

Theoretical considerations regarding the thione-thiol tautomerism in 2-(5-mercapto-1,3,4-thiadiazol-2-ylthio)acetic acid

Acta Chimica Slovenica, 2015
The acidity constants Ka1 and Ka2 of 2-(5-mercapto-1,3,4-thiadiazol-2-ylthio)acetic acid have been determined both by experimental and theoretical methods.
Raluca Oana Pop, Maria Ilici, Mihaiela Andoni, Vasile Nicolae Bercean, Cornelia Muntean, Monica M. Venter, Ilie Julean   +6 more
doaj   +1 more source

PolarEyes with enhanced digital imaging, a high‐throughput solution for locating and grading crystals

Journal of Applied Crystallography, Volume 59, Issue 5, Page 1557-1569, October 2026.
An open‐source program for the calculation and visualization of polarization‐derived properties of crystalline material is described, alongside the integration of a polarizing image sensor into a home‐built high‐throughput imaging setup.The long‐range internal order of crystals enables them to exhibit a well known and long‐exploited phenomenon ...
Thomas D. Smith, Alexandra Longcake, Michael J. Hall, Michael R. Probert   +3 more
wiley   +1 more source

Complex multitrophic species interactions and fitness costs: Intricate consequences of jasmonate and salicylate induced plant defences

Journal of Animal Ecology, Volume 95, Issue 10, Page 1859-1875, October 2026.
This study reveals how long‐term activation of jasmonic and salicylic acid signalling reshapes arthropod communities and plant fitness across seasons. By showing that induced defences generate contrasting outcomes and cascading trade‐offs across trophic levels, it challenges the assumption that induced resistance is uniformly beneficial in natural ...
Mônica F. Kersch‐Becker, Guilherme P. Pinheiro, Thaís S. Schweller, Martin Pareja, Victoria M. Pocius, José R. Trigo, Gustavo Q. Romero   +6 more
wiley   +1 more source

Biological Potential of Substituted Thiadiazole Compounds [PDF]

, 2015
Heterocyclic compounds are present in most biologically active molecules. The chemistry of heterocyclic compounds has been an interesting field of study.
Asif, Mohammad
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SYNTHESIS, ELECTRONIC AND SPECTRAL PROPERTIES OF NEW 1,3,4-THIADIAZOLE COMPOUNDS AND THE SPECTRAL ANALYSIS OF THEIR CONFORMERS USING DENSITY FUNCTIONAL THEORY

Química Nova
In this study, new 1,3,4-thiadiazole compounds were synthesised and characterised by FT-IR, 1H-NMR, UV-vis spectroscopy and elemental analysis, Furthermore, the relationship between the electronic and spectral data of the 16 conformers of each compound ...
Muhammet Serdar Çavuş, Tuğba Çelik
doaj   +1 more source

Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents

Molecules, 2007
A series of benzothiazol-2-yl-dithiocarbamates 3a-d along with their copper complexes 4a-c were synthesized via the reaction of suitable alkyl, aralkyl or heteroaryl halides with the sodium salt of benzothiazol-2-yl-dithiocarbamic acid, followed by ...
Mona A Mahran, Samia William, Fatem Ramzy, Amira M Sembel   +3 more
doaj   +1 more source

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents

, 2018
Georgeta Serban,1,* Oana Stanasel,2,* Eugenia Serban,3 Sanda Bota2,* 1Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania; 2Chemistry Department, Faculty of Sciences, University of Oradea, Oradea,
Serban G, Serban E, Stanasel O, Bota S
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