Results 71 to 80 of about 10,659 (219)

Thiadiazole derivatives as anticancer agents [PDF]

Pharmacological Reports, 2020
AbstractIn spite of substantial progress made toward understanding cancer pathogenesis, this disease remains one of the leading causes of mortality. Thus, there is an urgent need to develop novel, more effective anticancer therapeutics. Thiadiazole ring is a versatile scaffold widely studied in medicinal chemistry.
openaire   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Crystal structure of tetra-μ-acetato-bis[(5-amino-2-methylsulfanyl-1,3,4-thiadiazole-κN1)copper(II)]

Acta Crystallographica Section E: Crystallographic Communications, 2019
The reaction of 2-methylthio-5-amino-1,3,4-thiadiazole (Me-SNTD; C3H5N3S2) with copper(II) acetate monohydrate [Cu(OAc)2·H2O; C4H8CuO5] resulted in the formation of the title binuclear compound, [Cu2(C2H3O2)4(C3H5N3S2)2] or [Cu2(OAc)4(Me-SNTD)2].
Batirbay Torambetov, Shaxnoza Kadirova, Turdibek Toshmurodov, Jamshid Mengnorovich Ashurov, Nusrat Agzamovich Parpiev, Abdukhakim Ziyaev   +5 more
doaj   +1 more source

Synthesis and properties of 2-(4-phenyl-5-(((5-phenylamino-1,3,4-thiadiazole-2-yl)thio)methyl)-1,2,4-triazole-3-yl)thio)ethanoic acid and its salts

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
Analysis of the literature over the past decade has shown that the chemistry of 1,2,4-triazole and 1,3,4-thiadiazole attracts considerable interest from scientists around the world because of the many valuable properties of compounds of this class ...
A. S. Hotsulia , S. O. Fedotov
doaj   +1 more source

Design Principles for Next Generation of Small Organic Molecules for Photodynamics Therapy Revealed by Nonadiabatic Molecular Dynamics

Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.
Molecular design reshapes the landscape of excited‐state relaxation. Nonadiabatic dynamics reveal how electronic structure guides population flow between competing pathways beyond static energetic arguments. ABSTRACT Nitrobenzochalcogenadiazole derivatives are emerging candidates for photodynamic therapy (PDT), yet the precise mechanisms governing ...
Vinícius N. da Rocha, Davide Avagliano, Paulo C. Piquini   +2 more
wiley   +1 more source

2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents [PDF]

, 2018
Georgeta Serban,1,* Oana Stanasel,2,* Eugenia Serban,3 Sanda Bota2,* 1Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania; 2Chemistry Department, Faculty of Sciences, University of Oradea, Oradea,
Serban G, Serban E, Stanasel O, Bota S
core  

Aquabis[2,5-bis(pyridin-2-yl)-1,3,4-thiadiazole-κ2N2,N3](trifluoromethanesulfonato-κO)copper(II) trifluoromethanesulfonate

Acta Crystallographica Section E, 2012
2,5-Bis(pyridin-2-yl)-1,3,4-thiadiazole (denoted L) has been found to act as a bidentate ligand in the monomeric title complex, [Cu(CF3O3S)(C12H8N4S)2(H2O)](CF3O3S). The complex shows a distorted octahedrally coordinated copper(II) cation which is linked
Fouad Bentiss, Moha Outirite, Michel Lagrenée, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Iodine‐Mediated Electrochemical Diastereoselective Synthesis of Enaminones

ChemElectroChem, Volume 13, Issue 12, 17 June 2026.
This work describes an efficient electrochemical (EC) method for transforming thioamides into enaminones via reaction with organic diazo compounds. The electrochemical approach is cost‐effective, mild, and proceeds through the in situ electrochemical generation of a copper complex.
Ijaz Khan, Głowacki Michał P., Rybicka‐Jasińska Katarzyna   +2 more
wiley   +1 more source

Investigation of Anticancer Mechanism of Thiadiazole-Based Compound in Human Non-Small Cell Lung Cancer A549 Cells [PDF]

, 2008
In this study, we have synthesized several compounds and examined their cytotoxic effects on human non-small cell lung cancer A549 cells. We found that GO-13 ((EE)-2,5-bis[4- (3-dimethyl-aminopropoxy)styryl]-1,3,4- thiadiazole) is the most effective one ...
LAI, SHIN-YU;PAN, SHIOW-LIN;JOW, GUEY-MEI;CHERN, JI-WANG;GUH, JIH-HWA, 賴信羽;潘秀玲;卓貴美;陳基旺;顧記華   +1 more
core  

Water/Alkali-Catalyzed Reactions of Azides with 2‑Cyanothioacetamides. Eco-Friendly Synthesis of Monocyclic and Bicyclic 1,2,3-Thiadiazole-4-carbimidamides and 5‑Amino-1,2,3-triazole-4-carbothioamides [PDF]

, 2019
The reactions of thioamides with azides in water were studied. It was reliably shown that the reaction of 2-cyanothioacetamides 1 with various types of azides 2 in water in the presence of alkali presents an efficient, general, one-step, atom-economic ...
Nikolai A. Beliaev (7461455), Lidia N. Dianova (3901567), Wim Dehaen (496141), Albert T. Lebedev (1778380), Vladimir G. Ilkin (7461461), Valeriy O. Filimonov (3901573), Natalia N. Volkova (7461458), Tetyana V. Beryozkina (3901576), Dmitrii Mazur (7461452), Vasiliy A. Bakulev (3043827)   +9 more
core   +3 more sources