Results 61 to 70 of about 10,659 (219)

Smart molecular design of NIR‐II organic fluorophores through self‐driven iterative evolution, deep learning, and fragment‐based assembly

Smart Molecules, EarlyView.
A smart design strategy for NIR‐II organic fluorophores is proposed by combining self‐driven Iterative evolution, deep Learning, and fragment‐based assembly. This work establishes a broadly applicable approach for molecular design, accelerating the discovery of NIR‐II fluorophores and extending to optoelectronic materials and therapeutic compounds ...
Yu Zhang, Zhubin Hu, Xinyuan Wang, Zhenrong Sun, Yongye Liang, Cheng Zhong, Haitao Sun   +6 more
wiley   +1 more source

Complex multitrophic species interactions and fitness costs: Intricate consequences of jasmonate and salicylate induced plant defences

Journal of Animal Ecology, EarlyView.
This study reveals how long‐term activation of jasmonic and salicylic acid signalling reshapes arthropod communities and plant fitness across seasons. By showing that induced defences generate contrasting outcomes and cascading trade‐offs across trophic levels, it challenges the assumption that induced resistance is uniformly beneficial in natural ...
Mônica F. Kersch‐Becker, Guilherme P. Pinheiro, Thaís S. Schweller, Martin Pareja, Victoria M. Pocius, José R. Trigo, Gustavo Q. Romero   +6 more
wiley   +1 more source

Solvent Induced Disulfide Bond Formation in 2,5-dimercapto-1,3,4-thiadiazole [PDF]

, 2007
Disulfide bond formation is the decisive event in the protein folding to determine the conformation and stability of protein. To achieve this disulfide bond formation in vitro, we took 2,5-dimercapto-1,3,4-thiadiazole (DMcT) as a model compound. We found
Palraj Kalimuthu, S. Abraham John, Palanisamy Kalimuthu   +2 more
core   +1 more source

Thiadiazole Derivatives [PDF]

, 2020
In this study, a novel series of 2,6-disubstituted and 2,5,6-trisubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives were synthesized starting from 2-amino-1,3,4-thiadiazole derivatives.
Er, Mustafa, Hakan Alici, Meltem Dagli, Karakurt, Tuncay, Dağlı, Meltem, Tuncay Karakurt, Hakan Tahtaci, Alıcı, Hakan, Tahtaci, Hakan, Abdurrahman Onaran, Dagli, Meltem, Onaran, Abdurrahman, Mustafa Er, Alici, Hakan   +13 more
core   +1 more source

Design, Synthesis, Biological Evaluation and Molecular Docking Studies of New N-Heterocyclic Compounds as Aromatase Inhibitors

Pharmaceuticals
Background/Objectives: Breast cancer is the most common cancer and the second leading cause of cancer death in women. The aromatase enzyme plays a role in estrogen biosynthesis and is an important biological target for breast cancer treatment.
Fatih Tok, Begüm Nurpelin Sağlık Özkan, Yusuf Özkay, Zafer Asım Kaplancıklı   +3 more
doaj   +1 more source

A Proline‐Integrated Donor–Acceptor Fluorophore: Water‐Vapor‐Responsive Mechanochromic Luminescence and Latent Fingerprint Visualization

Advanced Optical Materials, Volume 14, Issue 25, 3 July 2026.
A proline‐integrated donor–acceptor fluorophore enables multifunctional luminescence through rational molecular design. Water‐vapor‐responsive mechanochromic luminescence (MCL) with circularly polarized luminescence (CPL) switching and efficient visualization of latent fingerprints (LFPs) are realized from this single small organic molecule.
Hao Chen, Kazuki Kato, Yoshitane Imai, Suguru Ito   +3 more
wiley   +1 more source

Synthesis and properties of thiadiazole lubricant additives [PDF]

, 2017
Purpose Thiadiazole compounds and their derivatives have carrying capacity and good lubricating properties. However, their poor oil-solubility limited their wide usage in lubricating oil.
Peng Wang, Xiaohong Xu, Wenquan Ma, Weiguo Xue, Tao Li, Xuguang Zhou   +5 more
core   +1 more source

4-[4-(4-Chloro-1,2,5-thiadiazol-3-yl)phenyl]morpholine

IUCrData
The title compound, C12H12ClN3OS, was prepared using a Suzuki–Miyaura cross-coupling reaction. The compound was found to crystallize in the orthorhombic system (space group Pbca, Z = 8).
Paul R. Palme, Richard Goddard, Adrian Richter, Peter Imming, Rüdiger W. Seidel   +4 more
doaj   +1 more source

N′-[5-Acetyl-3-(4-chlorophenyl)-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]-5-(1H-indol-3-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide dimethylformamide monosolvate

IUCrData, 2019
In the title solvate, C28H20ClN7O2S·C3H7NO, the main molecule consists of chlorophenyl (A), thiadiazolyl (B), pyrazolyl (C), phenyl (D) and indolyl (E) rings, with twist angles between neighbouring rings A/B, B/C, C/D and D/E of 32.6 (1), 14.8 (1), 60.8 (
Gamal A. El-Hiti, Bakr F. Abdel-Wahab, Emad Yousif, Mohammad Hayal Alotaibi, Amany S. Hegazy, Benson M. Kariuki   +5 more
doaj   +1 more source

2‐Pyrazoline‐5‐One Derivative Suppresses Cell Proliferation and Induces Apoptosis With Upregulation of Bax in Breast Cancer Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
2‐Pyrazoline‐5‐one derivative inhibits proliferation and migration and induces Bax‐mediated apoptosis in breast cancer cells. ABSTRACT The most common cancer in women worldwide is still breast cancer. Among its subtypes, luminal A and triple‐negative breast cancers present significant therapeutic challenges due to intrinsic drug resistance and absence ...
Sevgi Kocyigit Sevinc, Ş. Güniz Küçükgüzel, Sevim Rollas, Fulya Yukcu   +3 more
wiley   +1 more source