Results 61 to 70 of about 11,765 (225)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Thiadiazole Derivatives [PDF]

, 2020
In this study, a novel series of 2,6-disubstituted and 2,5,6-trisubstituted imidazo[2,1-b][1,3,4]thiadiazole derivatives were synthesized starting from 2-amino-1,3,4-thiadiazole derivatives.
Er, Mustafa, Hakan Alici, Meltem Dagli, Karakurt, Tuncay, Dağlı, Meltem, Tuncay Karakurt, Hakan Tahtaci, Alıcı, Hakan, Tahtaci, Hakan, Abdurrahman Onaran, Dagli, Meltem, Onaran, Abdurrahman, Mustafa Er, Alici, Hakan   +13 more
core   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

4-[4-(4-Chloro-1,2,5-thiadiazol-3-yl)phenyl]morpholine

IUCrData
The title compound, C12H12ClN3OS, was prepared using a Suzuki–Miyaura cross-coupling reaction. The compound was found to crystallize in the orthorhombic system (space group Pbca, Z = 8).
Paul R. Palme, Richard Goddard, Adrian Richter, Peter Imming, Rüdiger W. Seidel   +4 more
doaj   +1 more source

N′-[5-Acetyl-3-(4-chlorophenyl)-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]-5-(1H-indol-3-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide dimethylformamide monosolvate

IUCrData, 2019
In the title solvate, C28H20ClN7O2S·C3H7NO, the main molecule consists of chlorophenyl (A), thiadiazolyl (B), pyrazolyl (C), phenyl (D) and indolyl (E) rings, with twist angles between neighbouring rings A/B, B/C, C/D and D/E of 32.6 (1), 14.8 (1), 60.8 (
Gamal A. El-Hiti, Bakr F. Abdel-Wahab, Emad Yousif, Mohammad Hayal Alotaibi, Amany S. Hegazy, Benson M. Kariuki   +5 more
doaj   +1 more source

Band Engineering of Benzothiadiazole‐Derived Metal‐Organic Frameworks for Photocatalytic Organic Transformations

National Materials, EarlyView.
BTID‐functionalized metal‐organic frameworks provide a modular platform for tailoring photocatalytic electronic structures through acceptor‐linker engineering. By correlating band alignment, charge‐transfer characteristics, and reactive oxygen species generation, this review highlights design principles that enable efficient visible‐light‐driven ...
Xin Li, Long‐Shuang Chen, Meng‐Hao Li, Ying‐Wei Yang   +3 more
wiley   +1 more source

Synthesis and properties of 2-(4-phenyl-5-(((5-phenylamino-1,3,4-thiadiazole-2-yl)thio)methyl)-1,2,4-triazole-3-yl)thio)ethanoic acid and its salts

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
Analysis of the literature over the past decade has shown that the chemistry of 1,2,4-triazole and 1,3,4-thiadiazole attracts considerable interest from scientists around the world because of the many valuable properties of compounds of this class ...
A. S. Hotsulia , S. O. Fedotov
doaj   +1 more source

FXF‐OMe Is a Stable Tripeptide Motif for Ultra‐Short Peptide Coacervates That Establishes Structure‐Property‐Function Relationships

Small, EarlyView.
Ultra‐short peptides with a minimal sticker‐spacer structure undergo liquid‐liquid phase separation, resulting in condensates with microenvironments controlled by the hydrophobicity of the spacers. The condensates provide an easily tunable and exceptionally stable scaffold for photocatalytic microreactors in aqueous media, where catalysis efficiency is
Samuel Hamroff, Lucas Caire da Silva
wiley   +1 more source

Polar Switching and Cybotactic Nematic Ordering in 1,3,4-Thiadiazole-Based Short-Core Hockey Stick-Shaped Fluorescent Liquid Crystals

, 2019
We report here the synthesis and thermotropic properties of novel short-core hockey stick-shaped liquid crystalline molecules based on the 1,3,4-thiadiazole core.
Santosh Prasad Gupta (3387977), Sandip Kumar Saha, Raj Kumar Khan (4375600), Manoj Kumar Paul, Santanu Kumar Pal, Golam Mohiuddin (4375594), Manoj Kumar Paul (4051948), Raj Kumar Khan, Golam Mohiuddin, Sharmistha Ghosh, Santosh Prasad Gupta, Sharmistha Ghosh (4375606), Sandip Kumar Saha (6639842), Santanu Kumar Pal (757443)   +13 more
core   +1 more source

Crystal structure of tetra-μ-acetato-bis[(5-amino-2-methylsulfanyl-1,3,4-thiadiazole-κN1)copper(II)]

Acta Crystallographica Section E: Crystallographic Communications, 2019
The reaction of 2-methylthio-5-amino-1,3,4-thiadiazole (Me-SNTD; C3H5N3S2) with copper(II) acetate monohydrate [Cu(OAc)2·H2O; C4H8CuO5] resulted in the formation of the title binuclear compound, [Cu2(C2H3O2)4(C3H5N3S2)2] or [Cu2(OAc)4(Me-SNTD)2].
Batirbay Torambetov, Shaxnoza Kadirova, Turdibek Toshmurodov, Jamshid Mengnorovich Ashurov, Nusrat Agzamovich Parpiev, Abdukhakim Ziyaev   +5 more
doaj   +1 more source