Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole-Thiazole Hybrids as Potent Colon Cancer Inhibitors. [PDF]
Huwaimel B +6 more
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Targeting Glutaminase Isoforms GLS and GLS2 in Luminal Breast Cancer. [PDF]
Masisi BK +5 more
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Machine learning prediction of multiple distinct high-affinity chemotypes for α-synuclein fibrils. [PDF]
Li X +5 more
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Promising Norlabdane-Heterocyclic Hybrids: Synthesis, Structural Characterization and Antimicrobial Activity Evaluation. [PDF]
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Synthesis and Bioactivity Studies of Benzimidazole-Chalcone Hybrids. [PDF]
Makgoathana HD +4 more
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Recent advances in non-conventional synthesis of N-heterocyclic compounds: emerging strategies and biological perspectives. [PDF]
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Thiazolyl-Methylthio-1,3,4-Thiadiazole Hybrids as Halicin Analogues with Antimicrobial and Antibiofilm Activities: Chemical Development, Biological Assessment, and 2D-QSAR Study. [PDF]
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Summarization: Upon reaction of 4,5-disubstituted-N-arylaminoimidazole-2-thiones with isocyanides in the presence of azodicarboxylates (1.2 equiv) at rt, the imidazo[2,1-b][1,3,4]thiadiazoles were formed as the only reaction products in very good yields,
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A 1,2,3-thiadiazole–1,2,3-thiadiazole rearrangement
J. Chem. Soc., Chem. Commun., 1983During its preparation, 4-ethoxycarbonyl-5-diazomethyl-1,2,3-thiadiazole (4), undergoes a ring transformation into the isomeric structure (5), but when the ester function in (4) is replaced by a phenyl group, no isomerization is observed.
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