Results 41 to 50 of about 36,745 (354)

A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI

Frontiers in Neurology, 2018
Myalgia is sometimes observed in patients with thiamine-deficiency neuropathy. However, the detailed mechanism(s) underlying muscular manifestations have been poorly elucidated.
Kenichiro Murate, Yasuaki Mizutani, Toshiki Maeda, Ryunosuke Nagao, Kouichi Kikuchi, Sayuri Shima, Yoshiki Niimi, Akihiro Ueda, Shinji Ito, Tatsuro Mutoh   +9 more
doaj   +1 more source

An audit of the changes in thiamine levels during higher caloric nutritional rehabilitation of adolescent patients hospitalised with a restrictive eating disorder

Journal of Eating Disorders, 2020
Background Routine supplementation of thiamine in patients with restrictive eating disorders prior to initiation of nutritional rehabilitation, is an example of a clinical guideline based on expert opinion rather than evidence-based recommendations. This
Elizabeth Parker, Terri Maister, Anita Stefoska-Needham, Christine Wearne, Gail Anderson, Linette Gomes, Simon Clarke, Michael Kohn   +7 more
doaj   +1 more source

The first comprehensive LC–MS/MS method allowing dissection of the thiamine pathway in plants [PDF]

, 2020
Arabidopsis thaliana serves as a model plant for genetic research, including vitamin research. When aiming at engineering the thiamine (vitamin B1) pathway in plants, the availability of tools that allow the quantitative determination of different ...
Stove, Christophe, Strobbe, Simon, Van Der Straeten, Dominique, Verstraete, Jana   +3 more
core   +1 more source

Postgastrectomy polyneuropathy with thiamine deficiency [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2001
Polyneuropathy has been reported after gastrectomy performed to treat various lesions. Although thiamine deficiency is a possible cause of this neuropathy, the pathogenesis still remains to be clarified. Seventeen patients with peripheral neuropathy with thiamine deficiency after gastrectomy are described.Seventeen patients with polyneuropathy after ...
Gen Sobue, K. Misu, Masaaki Hirayama, Naoki Hattori, Masaaki Nagamatsu, I Sasaki, Shinji Ito, Hiroki Ito, Haruki Koike, Miyuki Ichimura   +9 more
openaire   +3 more sources

Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis. [PDF]

, 2016
ObjectivesThiamin deficiency is highly prevalent in patients with sepsis, but the mechanism by which sepsis induces thiamin deficiency is unknown. This study aimed to determine the influence of various severity of sepsis on carrier-mediated intestinal ...
Fang, Liwei, Said, Hamid M, Sassoon, Catherine S, Subramanian, Veedamali S, Zhu, Ercheng   +4 more
core   +2 more sources

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Advanced Biology, EarlyView.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation

Advanced Science, EarlyView.
Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao, Jiao‐Jiao Zhang, Meng‐Qi You, Han Wang, Yan Lin, Yuan Fang, Hui‐Lu Zhang, Yuan‐Yuan Qu, Qian Zhou, Meng Wang, Gang Li, Zi‐Fan Guo, Meng Xu, Jie Liu, Peng‐Cheng Lin, Yi‐Yuan Yuan, Yu Kang, Shi‐Min Zhao, Wei Xu   +18 more
wiley   +1 more source

Thiamine deficiency in diabetes, obesity and bariatric surgery: Recipes for diabetic ketoacidosis

Journal of Family Medicine and Primary Care
Diabetic ketoacidosis (DKA) is a life-threatening condition affecting individuals with diabetes characterised by hyperglycaemia, metabolic acidosis and ketonemia. The incidence and financial burden of DKA is still high.
Akhila Panda, Amirmohammad Heidari, Maryam Borumand, Musaab Ahmed, Ahmed Hassan, Mohamed H Ahmed   +5 more
doaj   +1 more source

Retromer Regulates Macro‐ and Micro‐Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus

Advanced Science, EarlyView.
In wild‐type of M. oryzae (Guy11), MoPrb1 and MoPep4 are delivered into the vacuole by the retromer complex to mediate protein degradation and selective autophagy. Their proper localization and catalytic functions are essential for the fungal vegetative growth, conidiation and pathogenicity. However, retromer mutations disrupt this transport, impairing
Dingyang Zhang, Jiexiong Hu, Yonghe Hong, Yuping Fan, Minghui Peng, Yakubu Saddeeq Abubakar, Shujing Liang, Nan Jiang, Lili Lin, Xiaohong Pan, Huakun Zheng, Naweed I. Naqvi, Zonghua Wang, Wenhui Zheng   +13 more
wiley   +1 more source

Rethinking the AI Paradigm for Solubility Prediction of Drug‑Like Compounds with Dual‐Perspective Modeling and Experimental Validation

Advanced Science, EarlyView.
Aqueous solubility governs drug delivery and bioavailability, yet its prediction remains challenging. Utilizing the largest curated dataset of drug‐like molecules, prediction models are constructed through dual‐perspective benchmarking. Stacking methods outperform advanced deep learning due to data constraints. These validated models enabled systematic
Qilin Zhu, Yuxin Qiu, Guzhong Chen, Wenyao Chen, Xiang Zhang, Zhiwen Qi, Xuezhi Duan, De Chen, Zhen Song   +8 more
wiley   +1 more source