Results 61 to 70 of about 449,811 (276)

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Thiamine status of whitefish (Coregonus maraena) in the Baltic Sea.

PLoS ONE
Many coregonine species have declined drastically across the Northern Hemisphere, including populations of Coregonus maraena (whitefish) in the Baltic Sea, and the mechanisms leading to these declines are not well investigated. An abrupt population crash
Marc M Hauber, Oscar Nordahl, Vittoria Todisco, Emil Fridolfsson, Petter Tibblin, Samuel Hylander   +5 more
doaj   +1 more source

Thiamine transporter 2 is involved in high glucose-induced damage and altered thiamine availability in cell models of diabetic retinopathy

Diabetes & Vascular Disease Research, 2020
Thiamine prevents high glucose-induced damage in microvasculature, and progression of retinopathy and nephropathy in diabetic animals. Impaired thiamine availability causes renal damage in diabetic patients. Two single-nucleotide polymorphisms in SLC19A3
Elena Beltramo, Aurora Mazzeo, Tatiana Lopatina, Marina Trento, Massimo Porta   +4 more
doaj   +1 more source

Wernicke’s encephalopathy mimicking multiple sclerosis in a young female patient post-bariatric gastric sleeve surgery

Journal of Community Hospital Internal Medicine Perspectives, 2021
We describe a case of Wernicke’s encephalopathy secondary to thiamine (B1) deficiency in a patient status post-bariatric sleeve gastrectomy. The presenting symptoms of new-onset weakness, diplopia, and confusion in a young female patient raised suspicion
Divya Lal, Maureen C. Farrell, Mahesh Krishnamurthy   +2 more
doaj   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Incidence of Thiamine Deficiency and Severity of Lactataemia in Patients with Diabetic Ketoacidosis: A Systematic Review

Diabetology
Objective: To perform a systematic literature review summarising current evidence of the incidence and clinical outcomes of thiamine deficiency in patients with diabetic ketoacidosis (DKA). Due to inconsistent and variable measurement of thiamine levels,
Aashish Kumar, Amanda Zahumensky, Rahima Habibullah, Jana Waldmann, Mahesh Ramanan   +4 more
doaj   +1 more source

Stage‐Dependent Metabolic Reprogramming Drives a Self‐Organizing Microbial Network During Shanxi Aged Vinegar

Food Bioengineering, EarlyView.
Metabolic shifts from growth to stress adaptation in Shanxi aged vinegar fermentation link flavor maturation and microbial cooperation, and Lactobacillus and Acetobacter form a self‐organizing metabolic network through division of labor. ABSTRACT Acetic acid fermentation (AAF) is a vital stage in the production of Shanxi aged vinegar (SAV), during ...
Yanfang Wu, Jing Liu, Dantong Liu, Menglei Xia, Jia Song, Yu Zheng, Min Wang   +6 more
wiley   +1 more source

Shoshin Beriberi in a Child With Intestinal Failure: A Case Report

Critical Care Explorations
Background:. Acute illness states with increased metabolic demand can precipitate severe thiamine deficiency if physiologic needs exceed endogenous stores and supplementation.
Madeleine Böhrer, MD, FRCPC, Paige Burgess, MD, FRCPC, Tais Da Costa Sao Pedro, MD, MSc, Dana Liza Boctor, MD, FCRPC, MSc, Samantha Boggs, MD, FRCPC, MEd   +4 more
doaj   +1 more source

Dietary factors leading to thiamine deficiency in salmon

, 2012
AbstraktiSalmonid species that suffer from thiamine deficiency contain high fat concentrations. Thiamine deficiency occurs when they have an unbalanced diet principally consisting of one prey fish species, and when very few prey species overall are ...
Vuorinen, Pekka J., Keinänen, Marja
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