Results 121 to 130 of about 7,524 (233)

Lower Risk of Cardiovascular Events in Patients With Clinical Atherosclerotic Cardiovascular Disease Who Initiated Semaglutide 2.4 mg in the Real‐World: Results From the SCORE—Clinical ASCVD Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4975-4990, June 2026.
ABSTRACT Aims To evaluate the association between semaglutide 2.4 mg and major adverse cardiovascular events (MACE) among adults with clinical atherosclerotic cardiovascular disease (ASCVD) and overweight/obesity without diabetes in real‐world clinical practice.
Michael G. Nanna, Carlos Mena‐Hurtado, Victoria Divino, Zhenxiang Zhao, Yan Chen, Joanna Boland, Jinlin Song, Andrea Traina, Kerem Ozer, Filip K. Knop, Kim G. Smolderen   +10 more
wiley   +1 more source

A Randomized Trial to Investigate the Effects of Low‐Dose Colchicine in Patients with Hypertension: Rationale and Design of the COlchicine and HypERtENsion Trial (COHERENT)

The Journal of Clinical Hypertension, Volume 28, Issue 6, June 2026.
ABSTRACT Hypertension is a prevalent and significant risk factor for cardiovascular disease (CVD). The immune system and inflammatory response are involved in the pathophysiology of hypertension. We hypothesize that treating hypertension with colchicine on top of standard therapy, will decrease pulse wave velocity (PWV), left ventricular mass, cardiac ...
Adam Femerling Langhoff, Niklas Dyrby Johansen, Marie Frimodt‐Møller, Ahmad Sajadieh, Tina Ken Schramm, Thomas A. Jepps, Tor Biering‐Sørensen   +6 more
wiley   +1 more source

Fixed‐Dose Combinations for Hypertension: Barriers to Use and Opportunities for Health Systems

The Journal of Clinical Hypertension, Volume 28, Issue 6, June 2026.
ABSTRACT Background: Uncontrolled hypertension is a leading driver of heart disease, chronic kidney disease, heart failure, dementia, stroke, and pregnancy‐related complications. Fixed‐dose combinations (FDCs) are guideline‐endorsed first‐line therapies that improve blood pressure control by reducing pill burden, improving adherence, and targeting ...
Pranay Narang, Josselyne Marquez, Neema Rashidi, Rohini Haar, Sandeep P. Kishore   +4 more
wiley   +1 more source

A potential association between tirzepatide and hypercalcemia in the setting of chronic hydrochlorothiazide use

Endocrinology, Diabetes & Metabolism Case Reports
Hypercalcemia is a prevalent electrolyte disturbance commonly associated with primary hyperparathyroidism, cancer, or medication adverse effects. Thiazide diuretics reduce urinary calcium excretion, increasing calcium reabsorption and hypercalcemia ...
Basil Nduma, Sai Nikhitha Malapati, Veeranna Vibhuti   +2 more
doaj   +1 more source

Effect of Body Mass Index on the Efficacy and Safety of Esaxerenone Versus Trichlormethiazide for the Treatment of Japanese Patients with Uncontrolled Essential Hypertension: A Subanalysis of the Excite‐HT Study

The Journal of Clinical Hypertension, Volume 28, Issue 6, June 2026.
ABSTRACT This prespecified, exploratory, body mass index (BMI)‐stratified analysis of the randomized, open‐label EXCITE‐HT study examined whether esaxerenone elicits a blood pressure (BP)‐lowering effect similar to trichlormethiazide in Japanese patients with uncontrolled essential hypertension.
Tomohiro Katsuya, Kazuomi Kario, Mitsuru Ohishi, Tatsuo Shimosawa, Kazuhito Shiosakai, Taketoshi Furugori, Takashi Taguchi, the EXCITE‐HT investigators   +7 more
wiley   +1 more source

The Use of Outpatient Diuretics Does Not Impact Somatic Growth in Infants With Bronchopulmonary Dysplasia

Pediatric Pulmonology, Volume 61, Issue 6, June 2026.
Brianna C. Aoyama, Sharon A. McGrath‐Morrow, Joseph M. Collaco   +2 more
wiley   +1 more source

Examining Multimorbidity in Older Adults Living in Naturally Occurring Retirement Communities, in Ontario, Canada, Using Latent Class Analysis

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1588-1602, June 2026.
ABSTRACT Background Multimorbidity, ≥ 2 chronic conditions as per the World Health Organization, can complicate aging in place and lead to earlier transitions to nursing homes. To inform supportive service intervention planning in naturally occurring retirement communities (NORCs), which are areas where large proportions of older adults reside, we ...
Albana Isai, Lavina Matai, Susan E. Bronskill, Patrick Feng, Longdi Fu, Shoshana Hahn‐Goldberg, Justine Humphries, Tai Huynh, Zhiyin Li, Tracy McQuire, Jen Recknagel, Paula A. Rochon, Nathan M. Stall, Xuesong Wang, Christina Yu, Rachel D. Savage   +15 more
wiley   +1 more source

Association of Combined Lifestyle Behaviors With Healthspan in Older Adults

Journal of the American Geriatrics Society, Volume 74, Issue 6, Page 1614-1625, June 2026.
In 11,287 older adults from the ASPirin in Reducing Events in the Elderly (ASPREE) cohort, healthy lifestyle behaviors were defined as Mediterranean diet, regular physical activity, moderate alcohol intake, and non‐smoking. Participants with three or more favorable behaviors had a 40% lower hazard of death, dementia, or persistent physical disability ...
Catherine Robb, Prudence R. Carr, Jocasta Ball, Galina Polekhina, Daniel Clayton‐Chubb, Elena S. George, Jessica Fitzpatrick, Lawrence J. Beilin, Anne B. Newman, Alice Owen, Suzanne G. Orchard, Cammie Tran, Joanne Ryan, John J. McNeil   +13 more
wiley   +1 more source

Therapeutics Letter 47

, 2003
Therapeutics Letter 47 reviews first-line treatments for hypertension. Conclusions: Total mortality, coronary heart disease and end-stage renal disease are similar for first-line thiazides, CCBs and ACEIs.
Therapeutics Initiative (University of British Columbia)
core  

Therapeutics Letter 7

, 1995
Therapeutics Letter 7 examines drugs of choice for the treatment of hypertension. Conclusions: based on the evidence available at this time and using criteria of effectiveness and cost, thiazides are clearly the drug of first choice.
Therapeutics Initiative (University of British Columbia)
core